Targeting STAT3 Abrogates Tim-3 Upregulation of Adaptive Resistance to PD-1 Blockade on Regulatory T Cells of Melanoma

Background Less than 20% of melanoma patients respond to programmed cell death-1 (PD-1) blockade immunotherapies. Thus, it is crucial to understand the dynamic changes in the tumor microenvironment (TME) after PD-1 blockade, for developing immunotherapy efficacy. Methods A genomic analysis was condu...

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Veröffentlicht in:	Frontiers in immunology 2021-04, Vol.12, p.654749-654749, Article 654749
Hauptverfasser:	Huang, Lili, Xu, Yu, Fang, Juemin, Liu, Weixing, Chen, Jianhua, Liu, Zhuqing, Xu, Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-PD-1 therapy Immunology Life Sciences & Biomedicine melanoma regulatory T cells Science & Technology STAT3 Tim-3
Online-Zugang:	Volltext
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