Emerging Approaches for Regulation and Control of CAR T Cells: A Mini Review

Chimeric antigen receptor (CAR) T cells have emerged as a promising treatment for patients with advanced B-cell cancers. However, widespread application of the therapy is currently limited by potentially life-threatening toxicities due to a lack of control of the highly potent transfused cells. Rese...

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Veröffentlicht in:	Frontiers in immunology 2020-02, Vol.11, p.326, Article 326
Hauptverfasser:	Brandt, Laerke J. B., Barnkob, Mike B., Michaels, Yale S., Heiselberg, Julia, Barington, Torben
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - immunology cancer Cell Hypoxia Cetuximab - pharmacology Cetuximab - therapeutic use chimeric antigen receptor CRISPR-Cas Systems Cytokine Release Syndrome - etiology Cytokine Release Syndrome - prevention & control Cytokines - biosynthesis Genes, Transgenic, Suicide Humans Immunology immunotherapy Immunotherapy, Adoptive - adverse effects Immunotherapy, Adoptive - methods Interleukin 1 Receptor Antagonist Protein - biosynthesis Life Sciences & Biomedicine Lymphocyte Activation Protease Inhibitors - pharmacology Protease Inhibitors - therapeutic use Protein Binding Protein Domains Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Chimeric Antigen - genetics Receptors, Chimeric Antigen - immunology regulation Rituximab - pharmacology Rituximab - therapeutic use Science & Technology synthetic T cell T-Cell Antigen Receptor Specificity T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - transplantation Tetracycline - pharmacology Transcription, Genetic - drug effects Transfection Tumor Microenvironment
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