Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD(+) Synthesis During Inflammation and Infection

Quinolinate (Quin) is a classic example of a biochemical double-edged sword, acting as both essential metabolite and potent neurotoxin. Quin is an important metabolite in the kynurenine pathway of tryptophan catabolism leading to the de novo synthesis of nicotinamide adenine dinucleotide (NAD(+)). A...

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Veröffentlicht in:	Frontiers in immunology 2020-02, Vol.11, p.31, Article 31
Hauptverfasser:	Moffett, John R., Arun, Peethambaran, Puthillathu, Narayanan, Vengilote, Ranjini, Ives, John A., Badawy, Abdulla A-B, Namboodiri, Aryan M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism cell motility Cell Movement - drug effects foam cells Gerbillinae Hippocampus - drug effects Hippocampus - metabolism HSP90 Heat-Shock Proteins - metabolism Immunity - drug effects Immunology indoleamine 2,3-dioxygenase Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Inflammation - immunology Inflammation - metabolism Kynurenine - administration & dosage Kynurenine - metabolism kynurenine pathway Life Sciences & Biomedicine Lipopolysaccharides - administration & dosage Liver - drug effects Liver - metabolism Male Mice Mice, Inbred C57BL NAD - biosynthesis PARP Pokeweed Mitogens - administration & dosage Poly(ADP-ribose) Polymerases - metabolism quinolinic acid Quinolinic Acid - immunology Quinolinic Acid - metabolism Rats Science & Technology Spleen - drug effects Spleen - metabolism Tryptophan - metabolism
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