Mupirocin resistance in clinical isolates of methicillin sensitive and resistant Staphylococcus aureus in a tertiary care centre of North India
Background: Staphylococcus aureus continues to be major healthcare problem worldwide as therapeutic options for its management are limited. Decolonisation regimes using mupiroicin are aimed at reducing the burden of infection due to this microorganism. However resistance to mupirocin poses a threat...
Gespeichert in:
| Veröffentlicht in: | JMS SKIMS 2019-11, Vol.22 (3) |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | |
| container_title | JMS SKIMS |
| container_volume | 22 |
| creator | Bali, Nargis Peer, Maroof Kour, Roseleen Ahmad, Suhail Koul, Parvaiz |
| description | Background: Staphylococcus aureus continues to be major healthcare problem worldwide as therapeutic options for its management are limited. Decolonisation regimes using mupiroicin are aimed at reducing the burden of infection due to this microorganism. However resistance to mupirocin poses a threat to the current standard eradication protocols.Aims: To find out the type and extent of mupirocin resistance in clinical isolates of S. aureus. Material and methods: This cross-sectional study was carried out at a tertiary care centre of North India for a period of 6 months. S. aureus recovered by standard microbiological procedures form various clinical samples such as blood, urine, pus and other body fluids was subjected to antimicrobial susceptibility testing along with detection of mupirocin resistance using 5 and 200µg discs. Minimum inhibitory concentration (MIC) of mupirocin was determined using E -test strips. Fisher’s exact test was done to determine the statistical significance. A P-value of |
| doi_str_mv | 10.33883/jms.v22i3.446 |
| format | Article |
| fullrecord | <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_33883_jms_v22i3_446</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_33883_jms_v22i3_446</sourcerecordid><originalsourceid>FETCH-LOGICAL-c846-4cab41354b244a694d71a480c7adee3c7930b04de665c540eb508bb3741a3ceb3</originalsourceid><addsrcrecordid>eNpNkE9Lw0AQxRdRsNRePe8XSNxkJ396lOKfQtWDPXgLk8mUjqRJ2d0W-in8yi5VxNObYXiPeT-lbjOTWlvX9u5z59NjnotNAcoLNTHzKk-yzHxc_puv1cx7aQ1ABYWBeqK-Xg57cSPJoB178QEHYh036mUQwl6LH3sM7PW40TsOWyHp4017HrwEObLGofszB_0ecL899SONRAev8eA4SjSgDuyCoDtpQseaeAhRYuzr6MJWL4dO8EZdbbD3PPvVqVo_PqwXz8nq7Wm5uF8lVEOZAGELmS2gzQGwnENXZQi1oQo7ZkvV3JrYsuOyLKgAw21h6ra1FWRoiVs7VelPLLnRe8ebZu9kF19rMtOcgTYRaHMG2kSg9hs3Lm5_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Mupirocin resistance in clinical isolates of methicillin sensitive and resistant Staphylococcus aureus in a tertiary care centre of North India</title><source>Alma/SFX Local Collection</source><creator>Bali, Nargis ; Peer, Maroof ; Kour, Roseleen ; Ahmad, Suhail ; Koul, Parvaiz</creator><creatorcontrib>Bali, Nargis ; Peer, Maroof ; Kour, Roseleen ; Ahmad, Suhail ; Koul, Parvaiz</creatorcontrib><description>Background: Staphylococcus aureus continues to be major healthcare problem worldwide as therapeutic options for its management are limited. Decolonisation regimes using mupiroicin are aimed at reducing the burden of infection due to this microorganism. However resistance to mupirocin poses a threat to the current standard eradication protocols.Aims: To find out the type and extent of mupirocin resistance in clinical isolates of S. aureus. Material and methods: This cross-sectional study was carried out at a tertiary care centre of North India for a period of 6 months. S. aureus recovered by standard microbiological procedures form various clinical samples such as blood, urine, pus and other body fluids was subjected to antimicrobial susceptibility testing along with detection of mupirocin resistance using 5 and 200µg discs. Minimum inhibitory concentration (MIC) of mupirocin was determined using E -test strips. Fisher’s exact test was done to determine the statistical significance. A P-value of <0.05 was considered as statistically significant.Results: A total of 247 S. aureus isolates were recovered of which 81 (32.8%) were resistant to methicillin (MRSA) whereas 166 (67.2%) were sensitive to this antibiotic (MSSA). Low level resistance to mupirocin was seen in 7 (8.6%) MRSA and 3 (1.8%) MSSA isolates. Prior use of this topical antibiotic and previous hospitalisation were found to be the risk factors associated with mupirocin resistance. Conclusion: Low level mupirocin resistance was seen in S. aureus isolates which if left unchecked could in future pave way for high level resistance and subsequent treatment failures.</description><identifier>ISSN: 0972-110X</identifier><identifier>EISSN: 0972-110X</identifier><identifier>DOI: 10.33883/jms.v22i3.446</identifier><language>eng</language><ispartof>JMS SKIMS, 2019-11, Vol.22 (3)</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c846-4cab41354b244a694d71a480c7adee3c7930b04de665c540eb508bb3741a3ceb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Bali, Nargis</creatorcontrib><creatorcontrib>Peer, Maroof</creatorcontrib><creatorcontrib>Kour, Roseleen</creatorcontrib><creatorcontrib>Ahmad, Suhail</creatorcontrib><creatorcontrib>Koul, Parvaiz</creatorcontrib><title>Mupirocin resistance in clinical isolates of methicillin sensitive and resistant Staphylococcus aureus in a tertiary care centre of North India</title><title>JMS SKIMS</title><description>Background: Staphylococcus aureus continues to be major healthcare problem worldwide as therapeutic options for its management are limited. Decolonisation regimes using mupiroicin are aimed at reducing the burden of infection due to this microorganism. However resistance to mupirocin poses a threat to the current standard eradication protocols.Aims: To find out the type and extent of mupirocin resistance in clinical isolates of S. aureus. Material and methods: This cross-sectional study was carried out at a tertiary care centre of North India for a period of 6 months. S. aureus recovered by standard microbiological procedures form various clinical samples such as blood, urine, pus and other body fluids was subjected to antimicrobial susceptibility testing along with detection of mupirocin resistance using 5 and 200µg discs. Minimum inhibitory concentration (MIC) of mupirocin was determined using E -test strips. Fisher’s exact test was done to determine the statistical significance. A P-value of <0.05 was considered as statistically significant.Results: A total of 247 S. aureus isolates were recovered of which 81 (32.8%) were resistant to methicillin (MRSA) whereas 166 (67.2%) were sensitive to this antibiotic (MSSA). Low level resistance to mupirocin was seen in 7 (8.6%) MRSA and 3 (1.8%) MSSA isolates. Prior use of this topical antibiotic and previous hospitalisation were found to be the risk factors associated with mupirocin resistance. Conclusion: Low level mupirocin resistance was seen in S. aureus isolates which if left unchecked could in future pave way for high level resistance and subsequent treatment failures.</description><issn>0972-110X</issn><issn>0972-110X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpNkE9Lw0AQxRdRsNRePe8XSNxkJ396lOKfQtWDPXgLk8mUjqRJ2d0W-in8yi5VxNObYXiPeT-lbjOTWlvX9u5z59NjnotNAcoLNTHzKk-yzHxc_puv1cx7aQ1ABYWBeqK-Xg57cSPJoB178QEHYh036mUQwl6LH3sM7PW40TsOWyHp4017HrwEObLGofszB_0ecL899SONRAev8eA4SjSgDuyCoDtpQseaeAhRYuzr6MJWL4dO8EZdbbD3PPvVqVo_PqwXz8nq7Wm5uF8lVEOZAGELmS2gzQGwnENXZQi1oQo7ZkvV3JrYsuOyLKgAw21h6ra1FWRoiVs7VelPLLnRe8ebZu9kF19rMtOcgTYRaHMG2kSg9hs3Lm5_</recordid><startdate>20191128</startdate><enddate>20191128</enddate><creator>Bali, Nargis</creator><creator>Peer, Maroof</creator><creator>Kour, Roseleen</creator><creator>Ahmad, Suhail</creator><creator>Koul, Parvaiz</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20191128</creationdate><title>Mupirocin resistance in clinical isolates of methicillin sensitive and resistant Staphylococcus aureus in a tertiary care centre of North India</title><author>Bali, Nargis ; Peer, Maroof ; Kour, Roseleen ; Ahmad, Suhail ; Koul, Parvaiz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c846-4cab41354b244a694d71a480c7adee3c7930b04de665c540eb508bb3741a3ceb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Bali, Nargis</creatorcontrib><creatorcontrib>Peer, Maroof</creatorcontrib><creatorcontrib>Kour, Roseleen</creatorcontrib><creatorcontrib>Ahmad, Suhail</creatorcontrib><creatorcontrib>Koul, Parvaiz</creatorcontrib><collection>CrossRef</collection><jtitle>JMS SKIMS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bali, Nargis</au><au>Peer, Maroof</au><au>Kour, Roseleen</au><au>Ahmad, Suhail</au><au>Koul, Parvaiz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mupirocin resistance in clinical isolates of methicillin sensitive and resistant Staphylococcus aureus in a tertiary care centre of North India</atitle><jtitle>JMS SKIMS</jtitle><date>2019-11-28</date><risdate>2019</risdate><volume>22</volume><issue>3</issue><issn>0972-110X</issn><eissn>0972-110X</eissn><abstract>Background: Staphylococcus aureus continues to be major healthcare problem worldwide as therapeutic options for its management are limited. Decolonisation regimes using mupiroicin are aimed at reducing the burden of infection due to this microorganism. However resistance to mupirocin poses a threat to the current standard eradication protocols.Aims: To find out the type and extent of mupirocin resistance in clinical isolates of S. aureus. Material and methods: This cross-sectional study was carried out at a tertiary care centre of North India for a period of 6 months. S. aureus recovered by standard microbiological procedures form various clinical samples such as blood, urine, pus and other body fluids was subjected to antimicrobial susceptibility testing along with detection of mupirocin resistance using 5 and 200µg discs. Minimum inhibitory concentration (MIC) of mupirocin was determined using E -test strips. Fisher’s exact test was done to determine the statistical significance. A P-value of <0.05 was considered as statistically significant.Results: A total of 247 S. aureus isolates were recovered of which 81 (32.8%) were resistant to methicillin (MRSA) whereas 166 (67.2%) were sensitive to this antibiotic (MSSA). Low level resistance to mupirocin was seen in 7 (8.6%) MRSA and 3 (1.8%) MSSA isolates. Prior use of this topical antibiotic and previous hospitalisation were found to be the risk factors associated with mupirocin resistance. Conclusion: Low level mupirocin resistance was seen in S. aureus isolates which if left unchecked could in future pave way for high level resistance and subsequent treatment failures.</abstract><doi>10.33883/jms.v22i3.446</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0972-110X |
| ispartof | JMS SKIMS, 2019-11, Vol.22 (3) |
| issn | 0972-110X 0972-110X |
| language | eng |
| recordid | cdi_crossref_primary_10_33883_jms_v22i3_446 |
| source | Alma/SFX Local Collection |
| title | Mupirocin resistance in clinical isolates of methicillin sensitive and resistant Staphylococcus aureus in a tertiary care centre of North India |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T05%3A56%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mupirocin%20resistance%20in%20clinical%20isolates%20of%20methicillin%20sensitive%20and%20resistant%20Staphylococcus%20aureus%20in%20a%20tertiary%20care%20centre%20of%20North%20India&rft.jtitle=JMS%20SKIMS&rft.au=Bali,%20Nargis&rft.date=2019-11-28&rft.volume=22&rft.issue=3&rft.issn=0972-110X&rft.eissn=0972-110X&rft_id=info:doi/10.33883/jms.v22i3.446&rft_dat=%3Ccrossref%3E10_33883_jms_v22i3_446%3C/crossref%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |