Toxic effects and changes of blood components by photodynamic action induced by pheophorbide-a in rats [Chlorella-derived substances, Japan]
In order to clarify the effects of pheophorbide-a, a Chlorella-derived substance with photodynamic activity, the substance was administered orally to rats and on the following day they were irradiated with 20, 000 lux of visible light. The toxic effects on these animals were observed, and analysis o...
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| Veröffentlicht in: | Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 1982/10/05, Vol.23(5), pp.365-372_1 |
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| container_title | Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) |
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| creator | Matuura, E Saito, Y Ishida, H Seki, Y Miki, K |
| description | In order to clarify the effects of pheophorbide-a, a Chlorella-derived substance with photodynamic activity, the substance was administered orally to rats and on the following day they were irradiated with 20, 000 lux of visible light. The toxic effects on these animals were observed, and analysis of blood components and of the resistance of erythrocytes was performed. The results obtained were as follows: 1) Redness was frequently observed on the skin at the auricle and the tail, but scarcely any edema was observed at the occipital and the dorsal positions. 2) LD50 of pheophorbide-a was reduced as the irradiation time with visible light was increased. 3) Toxicity of pheophorbide-a to rats no longer seen by the 4th day after administration, so this substance might be relatively quickly excreted or decomposed. 4) The number of erythrocytes, levels of hemoglobin concentration and hematocrit were increased in the experimental animals. It was also observed that the percentage of rod-shaped nuclear neutrophilic leukocytes in the leukocyte population increased (p |
| doi_str_mv | 10.3358/shokueishi.23.365 |
| format | Article |
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The toxic effects on these animals were observed, and analysis of blood components and of the resistance of erythrocytes was performed. The results obtained were as follows: 1) Redness was frequently observed on the skin at the auricle and the tail, but scarcely any edema was observed at the occipital and the dorsal positions. 2) LD50 of pheophorbide-a was reduced as the irradiation time with visible light was increased. 3) Toxicity of pheophorbide-a to rats no longer seen by the 4th day after administration, so this substance might be relatively quickly excreted or decomposed. 4) The number of erythrocytes, levels of hemoglobin concentration and hematocrit were increased in the experimental animals. It was also observed that the percentage of rod-shaped nuclear neutrophilic leukocytes in the leukocyte population increased (p<0.05) and that of lymphocytes decreased significantly (p<0.05). 5) Among serum electrolytes, no significant differences in the levels of calcium and inorganic phosphorus were recognized between the animals of the experimental group and the control group. However, the sodium level of the experimental group showed a significant decrease and the potassium level showed a marked increase as compared with those of the control group. 6) There were no significant differences in serum bilirubin content, serum protein fractions and lipoperoxidase level between these two groups. 7) Among serum enzymes, no differences in the levels of GOT, GPT, LDH and Al-P were found between these groups, but the level of CPK of the experimental group was markedly increased compared with that of the control group. 8) No difference of mean corpuscular fragility of erythrocytes was recognized between these two groups.</description><identifier>ISSN: 0015-6426</identifier><identifier>EISSN: 1882-1006</identifier><identifier>DOI: 10.3358/shokueishi.23.365</identifier><language>eng ; jpn</language><publisher>Japanese Society for Food Hygiene and Safety</publisher><subject>a pheophorbide-a ; blood components ; corpuscular osmotic fragility ; photodynamic action ; rat</subject><ispartof>Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 1982/10/05, Vol.23(5), pp.365-372_1</ispartof><rights>The Food Hygienic Society of Japan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3495-4665373f1cdeb68cc4d63eccb5fd84cd915352db96acaa340e8b4d1a40519b3a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids></links><search><creatorcontrib>Matuura, E</creatorcontrib><creatorcontrib>Saito, Y</creatorcontrib><creatorcontrib>Ishida, H</creatorcontrib><creatorcontrib>Seki, Y</creatorcontrib><creatorcontrib>Miki, K</creatorcontrib><title>Toxic effects and changes of blood components by photodynamic action induced by pheophorbide-a in rats [Chlorella-derived substances, Japan]</title><title>Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)</title><addtitle>Food Hyg. Saf. Sci.</addtitle><description>In order to clarify the effects of pheophorbide-a, a Chlorella-derived substance with photodynamic activity, the substance was administered orally to rats and on the following day they were irradiated with 20, 000 lux of visible light. The toxic effects on these animals were observed, and analysis of blood components and of the resistance of erythrocytes was performed. The results obtained were as follows: 1) Redness was frequently observed on the skin at the auricle and the tail, but scarcely any edema was observed at the occipital and the dorsal positions. 2) LD50 of pheophorbide-a was reduced as the irradiation time with visible light was increased. 3) Toxicity of pheophorbide-a to rats no longer seen by the 4th day after administration, so this substance might be relatively quickly excreted or decomposed. 4) The number of erythrocytes, levels of hemoglobin concentration and hematocrit were increased in the experimental animals. It was also observed that the percentage of rod-shaped nuclear neutrophilic leukocytes in the leukocyte population increased (p<0.05) and that of lymphocytes decreased significantly (p<0.05). 5) Among serum electrolytes, no significant differences in the levels of calcium and inorganic phosphorus were recognized between the animals of the experimental group and the control group. However, the sodium level of the experimental group showed a significant decrease and the potassium level showed a marked increase as compared with those of the control group. 6) There were no significant differences in serum bilirubin content, serum protein fractions and lipoperoxidase level between these two groups. 7) Among serum enzymes, no differences in the levels of GOT, GPT, LDH and Al-P were found between these groups, but the level of CPK of the experimental group was markedly increased compared with that of the control group. 8) No difference of mean corpuscular fragility of erythrocytes was recognized between these two groups.</description><subject>a pheophorbide-a</subject><subject>blood components</subject><subject>corpuscular osmotic fragility</subject><subject>photodynamic action</subject><subject>rat</subject><issn>0015-6426</issn><issn>1882-1006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><recordid>eNpNkN2KFDEQhYMoOKz7AF6ZB7DH_G_3pQz-LQteuHslEipJ9XS0JxmSHtl5Bx_aLC3r3lRBnfMdikPIa862Uur-XZ3yrxPGOsWtkFtp9DOy4X0vOs6YeU42jHHdGSXMS3JZa3SMseFKSCE25M9tvo-e4jiiXyqFFKifIO2x0jxSN-fcDvlwzAlT092ZHqe85HBOcGgc-CXmRGMKJ49hlTE3S3ExYAdNoQUa-H03zbngPEMXsMTfzVxPri6QPNa39BqOkH68Ii9GmCte_tsX5O7jh9vd5-7m66cvu_c3nZdq0J0yRssrOXIf0JneexWMRO-dHkOvfBi4lloENxjwAFIx7J0KHBTTfHAS5AXha64vudaCoz2WeIBytpzZh0bt_0atkLY12pjrlfnZnt7jIwFliX7GJwQfDHug9Doa_Ghq1RaLqYW9WcNGyBb2JVZ7900wLpngRgim5F_URZRC</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Matuura, E</creator><creator>Saito, Y</creator><creator>Ishida, H</creator><creator>Seki, Y</creator><creator>Miki, K</creator><general>Japanese Society for Food Hygiene and Safety</general><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1982</creationdate><title>Toxic effects and changes of blood components by photodynamic action induced by pheophorbide-a in rats [Chlorella-derived substances, Japan]</title><author>Matuura, E ; Saito, Y ; Ishida, H ; Seki, Y ; Miki, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3495-4665373f1cdeb68cc4d63eccb5fd84cd915352db96acaa340e8b4d1a40519b3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>1982</creationdate><topic>a pheophorbide-a</topic><topic>blood components</topic><topic>corpuscular osmotic fragility</topic><topic>photodynamic action</topic><topic>rat</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matuura, E</creatorcontrib><creatorcontrib>Saito, Y</creatorcontrib><creatorcontrib>Ishida, H</creatorcontrib><creatorcontrib>Seki, Y</creatorcontrib><creatorcontrib>Miki, K</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><jtitle>Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matuura, E</au><au>Saito, Y</au><au>Ishida, H</au><au>Seki, Y</au><au>Miki, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxic effects and changes of blood components by photodynamic action induced by pheophorbide-a in rats [Chlorella-derived substances, Japan]</atitle><jtitle>Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)</jtitle><addtitle>Food Hyg. Saf. Sci.</addtitle><date>1982</date><risdate>1982</risdate><volume>23</volume><issue>5</issue><spage>365</spage><epage>372</epage><pages>365-372</pages><issn>0015-6426</issn><eissn>1882-1006</eissn><abstract>In order to clarify the effects of pheophorbide-a, a Chlorella-derived substance with photodynamic activity, the substance was administered orally to rats and on the following day they were irradiated with 20, 000 lux of visible light. The toxic effects on these animals were observed, and analysis of blood components and of the resistance of erythrocytes was performed. The results obtained were as follows: 1) Redness was frequently observed on the skin at the auricle and the tail, but scarcely any edema was observed at the occipital and the dorsal positions. 2) LD50 of pheophorbide-a was reduced as the irradiation time with visible light was increased. 3) Toxicity of pheophorbide-a to rats no longer seen by the 4th day after administration, so this substance might be relatively quickly excreted or decomposed. 4) The number of erythrocytes, levels of hemoglobin concentration and hematocrit were increased in the experimental animals. It was also observed that the percentage of rod-shaped nuclear neutrophilic leukocytes in the leukocyte population increased (p<0.05) and that of lymphocytes decreased significantly (p<0.05). 5) Among serum electrolytes, no significant differences in the levels of calcium and inorganic phosphorus were recognized between the animals of the experimental group and the control group. However, the sodium level of the experimental group showed a significant decrease and the potassium level showed a marked increase as compared with those of the control group. 6) There were no significant differences in serum bilirubin content, serum protein fractions and lipoperoxidase level between these two groups. 7) Among serum enzymes, no differences in the levels of GOT, GPT, LDH and Al-P were found between these groups, but the level of CPK of the experimental group was markedly increased compared with that of the control group. 8) No difference of mean corpuscular fragility of erythrocytes was recognized between these two groups.</abstract><pub>Japanese Society for Food Hygiene and Safety</pub><doi>10.3358/shokueishi.23.365</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 1982/10/05, Vol.23(5), pp.365-372_1 |
| issn | 0015-6426 1882-1006 |
| language | eng ; jpn |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | a pheophorbide-a blood components corpuscular osmotic fragility photodynamic action rat |
| title | Toxic effects and changes of blood components by photodynamic action induced by pheophorbide-a in rats [Chlorella-derived substances, Japan] |
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