Propofol-induced mitochondrial and contractile dysfunction of the rat ventricular myocardium

Propofol is a short-acting hypnotic agent used in human medicine for sedation and general anesthesia. Its administration can be associated with serious cardiovascular side-effects that include decrease in arterial blood pressure and cardiac output. The aim of the present study was to evaluate propof...

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Veröffentlicht in:	Physiological research 2016-01, Vol.65 (Suppl 5), p.S601-S609
Hauptverfasser:	Grundmanová, M, Jarkovská, D, Süß, A, Tůma, Z, Marková, M, Grundman, Z, El-Kadi, A, Čedíková, M, Štengl, M, Kuncová, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Animals Cardiac Output - drug effects Cardiac Output - physiology Dose-Response Relationship, Drug Heart Ventricles - drug effects Heart Ventricles - physiopathology Hypnotics and Sedatives - toxicity Male Mitochondria, Heart - drug effects Mitochondria, Heart - physiology Myocardial Contraction - drug effects Myocardial Contraction - physiology Oxygen Consumption - drug effects Oxygen Consumption - physiology Propofol - toxicity Rats Rats, Wistar
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