Comparison of Rate of Infection during Hydroxyapatite and Allogenic Bone Graft Used In Jaw Cyst: A Randomized Clinical Trial
Background: The course of hepatitis B virus (HBV) infection is not only determined by variations in viral virulence but may be influenced by host immune response, where Human Leukocyte Antigen (HLA) plays an important role. Objective: The purpose of the present study was to explore whether HLA-DRB13...
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| Veröffentlicht in: | Bangladesh journal of infectious diseases 2020-03, Vol.6 (2), p.39-43 |
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| container_title | Bangladesh journal of infectious diseases |
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| creator | Akhter, Rokshana Shirin, Afzalunnessa Tabassum, Shahina Hossen, Murad |
| description | Background: The course of hepatitis B virus (HBV) infection is not only determined by variations in viral virulence but may be influenced by host immune response, where Human Leukocyte Antigen (HLA) plays an important role.
Objective: The purpose of the present study was to explore whether HLA-DRB13* allele of MHC gene had any influence in spontaneous recovery from HBV infection among Bangladeshi adults.
Method: This cross sectional study was carried out at the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka Bangladesh. A total of 90 randomly selected hepatitis B virus infected adult patients, consisting of 30 acute HBV infections, 30 chronic HBV infection and 30 healthy controls were selected according to selection criteria for evaluation of HLA DRB1*13 allele. Detection of HLA DRB1*13 allele was done by conventional PCR followed by agarose gel electrophoresis.
Result: The study revealed a significant increase of DRB1*13 in acute hepatitis B (AHB vs HC-40% vs 6.7%, RR= 9.4; P value |
| doi_str_mv | 10.3329/bjid.v6i2.46103 |
| format | Article |
| fullrecord | <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_3329_bjid_v6i2_46103</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_3329_bjid_v6i2_46103</sourcerecordid><originalsourceid>FETCH-crossref_primary_10_3329_bjid_v6i2_461033</originalsourceid><addsrcrecordid>eNqVj8tOwzAQRS0EEhV0zXZ-oKkdRymwKxHQskRFYmcNsVNN5diRbR5BfDwO6g-wuqO5c0Y6jF0JXkhZ3izfDqSLj5rKoqoFlydsVlZCLOoVfz09ztV1yc_ZPMYD57yUQq64mLGfxvcDBorege_gGZOZcus60ybKS_0eyO1hM-rgv0YcMFE-Qadhba3fG0ct3Hln4DFgl-AlGp1peMJPaMaYbmGdnzrte_rOTWMpA2hhFwjtJTvr0EYzP-YFWz7c75rNog0-xmA6NQTqMYxKcDV5qslTTZ7qz1P-n_gFtWJdrQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Comparison of Rate of Infection during Hydroxyapatite and Allogenic Bone Graft Used In Jaw Cyst: A Randomized Clinical Trial</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Akhter, Rokshana ; Shirin, Afzalunnessa ; Tabassum, Shahina ; Hossen, Murad</creator><creatorcontrib>Akhter, Rokshana ; Shirin, Afzalunnessa ; Tabassum, Shahina ; Hossen, Murad</creatorcontrib><description>Background: The course of hepatitis B virus (HBV) infection is not only determined by variations in viral virulence but may be influenced by host immune response, where Human Leukocyte Antigen (HLA) plays an important role.
Objective: The purpose of the present study was to explore whether HLA-DRB13* allele of MHC gene had any influence in spontaneous recovery from HBV infection among Bangladeshi adults.
Method: This cross sectional study was carried out at the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka Bangladesh. A total of 90 randomly selected hepatitis B virus infected adult patients, consisting of 30 acute HBV infections, 30 chronic HBV infection and 30 healthy controls were selected according to selection criteria for evaluation of HLA DRB1*13 allele. Detection of HLA DRB1*13 allele was done by conventional PCR followed by agarose gel electrophoresis.
Result: The study revealed a significant increase of DRB1*13 in acute hepatitis B (AHB vs HC-40% vs 6.7%, RR= 9.4; P value <0.05, AHB vs CHB=40% vs 10%; RR=2.27, P value <0.05) compared to chronic hepatitis B infected (HBV) patients and healthy controls (CHB vs HC-10% vs 6.7%, RR= 1.5, P>0.05). This is the first report on HLA DRB1* gene associations among hepatitis B (HBV) infected Bangladeshi patients.
Conclusion: The present study revealed that HLA DRB1*13 was associated with protection against persistent HBV infection among acutely infected adult HBV patients in Bangladesh.
Bangladesh Journal of Infectious Diseases 2019;6(2):39-43</description><identifier>ISSN: 2411-4820</identifier><identifier>EISSN: 2411-670X</identifier><identifier>DOI: 10.3329/bjid.v6i2.46103</identifier><language>eng</language><ispartof>Bangladesh journal of infectious diseases, 2020-03, Vol.6 (2), p.39-43</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Akhter, Rokshana</creatorcontrib><creatorcontrib>Shirin, Afzalunnessa</creatorcontrib><creatorcontrib>Tabassum, Shahina</creatorcontrib><creatorcontrib>Hossen, Murad</creatorcontrib><title>Comparison of Rate of Infection during Hydroxyapatite and Allogenic Bone Graft Used In Jaw Cyst: A Randomized Clinical Trial</title><title>Bangladesh journal of infectious diseases</title><description>Background: The course of hepatitis B virus (HBV) infection is not only determined by variations in viral virulence but may be influenced by host immune response, where Human Leukocyte Antigen (HLA) plays an important role.
Objective: The purpose of the present study was to explore whether HLA-DRB13* allele of MHC gene had any influence in spontaneous recovery from HBV infection among Bangladeshi adults.
Method: This cross sectional study was carried out at the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka Bangladesh. A total of 90 randomly selected hepatitis B virus infected adult patients, consisting of 30 acute HBV infections, 30 chronic HBV infection and 30 healthy controls were selected according to selection criteria for evaluation of HLA DRB1*13 allele. Detection of HLA DRB1*13 allele was done by conventional PCR followed by agarose gel electrophoresis.
Result: The study revealed a significant increase of DRB1*13 in acute hepatitis B (AHB vs HC-40% vs 6.7%, RR= 9.4; P value <0.05, AHB vs CHB=40% vs 10%; RR=2.27, P value <0.05) compared to chronic hepatitis B infected (HBV) patients and healthy controls (CHB vs HC-10% vs 6.7%, RR= 1.5, P>0.05). This is the first report on HLA DRB1* gene associations among hepatitis B (HBV) infected Bangladeshi patients.
Conclusion: The present study revealed that HLA DRB1*13 was associated with protection against persistent HBV infection among acutely infected adult HBV patients in Bangladesh.
Bangladesh Journal of Infectious Diseases 2019;6(2):39-43</description><issn>2411-4820</issn><issn>2411-670X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqVj8tOwzAQRS0EEhV0zXZ-oKkdRymwKxHQskRFYmcNsVNN5diRbR5BfDwO6g-wuqO5c0Y6jF0JXkhZ3izfDqSLj5rKoqoFlydsVlZCLOoVfz09ztV1yc_ZPMYD57yUQq64mLGfxvcDBorege_gGZOZcus60ybKS_0eyO1hM-rgv0YcMFE-Qadhba3fG0ct3Hln4DFgl-AlGp1peMJPaMaYbmGdnzrte_rOTWMpA2hhFwjtJTvr0EYzP-YFWz7c75rNog0-xmA6NQTqMYxKcDV5qslTTZ7qz1P-n_gFtWJdrQ</recordid><startdate>20200320</startdate><enddate>20200320</enddate><creator>Akhter, Rokshana</creator><creator>Shirin, Afzalunnessa</creator><creator>Tabassum, Shahina</creator><creator>Hossen, Murad</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200320</creationdate><title>Comparison of Rate of Infection during Hydroxyapatite and Allogenic Bone Graft Used In Jaw Cyst: A Randomized Clinical Trial</title><author>Akhter, Rokshana ; Shirin, Afzalunnessa ; Tabassum, Shahina ; Hossen, Murad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-crossref_primary_10_3329_bjid_v6i2_461033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Akhter, Rokshana</creatorcontrib><creatorcontrib>Shirin, Afzalunnessa</creatorcontrib><creatorcontrib>Tabassum, Shahina</creatorcontrib><creatorcontrib>Hossen, Murad</creatorcontrib><collection>CrossRef</collection><jtitle>Bangladesh journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akhter, Rokshana</au><au>Shirin, Afzalunnessa</au><au>Tabassum, Shahina</au><au>Hossen, Murad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Rate of Infection during Hydroxyapatite and Allogenic Bone Graft Used In Jaw Cyst: A Randomized Clinical Trial</atitle><jtitle>Bangladesh journal of infectious diseases</jtitle><date>2020-03-20</date><risdate>2020</risdate><volume>6</volume><issue>2</issue><spage>39</spage><epage>43</epage><pages>39-43</pages><issn>2411-4820</issn><eissn>2411-670X</eissn><abstract>Background: The course of hepatitis B virus (HBV) infection is not only determined by variations in viral virulence but may be influenced by host immune response, where Human Leukocyte Antigen (HLA) plays an important role.
Objective: The purpose of the present study was to explore whether HLA-DRB13* allele of MHC gene had any influence in spontaneous recovery from HBV infection among Bangladeshi adults.
Method: This cross sectional study was carried out at the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka Bangladesh. A total of 90 randomly selected hepatitis B virus infected adult patients, consisting of 30 acute HBV infections, 30 chronic HBV infection and 30 healthy controls were selected according to selection criteria for evaluation of HLA DRB1*13 allele. Detection of HLA DRB1*13 allele was done by conventional PCR followed by agarose gel electrophoresis.
Result: The study revealed a significant increase of DRB1*13 in acute hepatitis B (AHB vs HC-40% vs 6.7%, RR= 9.4; P value <0.05, AHB vs CHB=40% vs 10%; RR=2.27, P value <0.05) compared to chronic hepatitis B infected (HBV) patients and healthy controls (CHB vs HC-10% vs 6.7%, RR= 1.5, P>0.05). This is the first report on HLA DRB1* gene associations among hepatitis B (HBV) infected Bangladeshi patients.
Conclusion: The present study revealed that HLA DRB1*13 was associated with protection against persistent HBV infection among acutely infected adult HBV patients in Bangladesh.
Bangladesh Journal of Infectious Diseases 2019;6(2):39-43</abstract><doi>10.3329/bjid.v6i2.46103</doi></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| title | Comparison of Rate of Infection during Hydroxyapatite and Allogenic Bone Graft Used In Jaw Cyst: A Randomized Clinical Trial |
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