Tspan18 is a novel regulator of the Ca 2+ channel Orai1 and von Willebrand factor release in endothelial cells

Ca entry Orai1 store-operated Ca channels in the plasma membrane is critical to cell function, and Orai1 loss causes severe immunodeficiency and developmental defects. The tetraspanins are a superfamily of transmembrane proteins that interact with specific 'partner proteins' and regulate t...

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Veröffentlicht in:	Haematologica (Roma) 2019-09, Vol.104 (9), p.1892-1905
Hauptverfasser:	Noy, Peter J, Gavin, Rebecca L, Colombo, Dario, Haining, Elizabeth J, Reyat, Jasmeet S, Payne, Holly, Thielmann, Ina, Lokman, Adam B, Neag, Georgiana, Yang, Jing, Lloyd, Tammy, Harrison, Neale, Heath, Victoria L, Gardiner, Chris, Whitworth, Katharine M, Robinson, Joseph, Koo, Chek Z, Di Maio, Alessandro, Harrison, Paul, Lee, Steven P, Michelangeli, Francesco, Kalia, Neena, Rainger, G Ed, Nieswandt, Bernhard, Brill, Alexander, Watson, Steve P, Tomlinson, Michael G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - cytology B-Lymphocytes - drug effects B-Lymphocytes - metabolism Calcium - metabolism Chickens Disease Models, Animal Gene Expression Regulation HEK293 Cells HeLa Cells Histamine - pharmacology Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Ion Transport - drug effects Jurkat Cells Mice Mice, Inbred C57BL Mice, Knockout Myocardial Reperfusion Injury - genetics Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism ORAI1 Protein - genetics ORAI1 Protein - metabolism Signal Transduction Tetraspanins - genetics Tetraspanins - metabolism Thrombin - pharmacology Venous Thrombosis - genetics Venous Thrombosis - metabolism Venous Thrombosis - pathology von Willebrand Factor - genetics von Willebrand Factor - metabolism
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