Comparative study of the inhibitory effects of adrenomedullin on angiotensin II contraction in rat conductance and resistance arteries
Adrenomedullin (ADM), a ubiquitous vasoactive peptide, has been the target of a multitude of studies concerning its effect on the vascular tone. The present work aims at clarifying a series of its interactions with the renin-angiotensin system. The study uses the rat aorta ring as a model of conduct...
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| Veröffentlicht in: | Journal of the renin-angiotensin-aldosterone system 2004-06, Vol.5 (2), p.79-83 |
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| container_title | Journal of the renin-angiotensin-aldosterone system |
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| creator | Haulica, Ion Bild, Walther Mihaila, Christian Serban, Dragomir N Serban, Lacramioara Boisteanu, Daniela Ionita, Teodor Radasanu, Oana |
| description | Adrenomedullin (ADM), a ubiquitous vasoactive peptide, has been the target of a multitude of studies concerning its effect on the vascular tone. The present work aims at clarifying a series of its interactions with the renin-angiotensin system.
The study uses the rat aorta ring as a model of conductance vessels, with or without vascular endothelium, and the second order branch of rat mesenteric arteries as a model of resistance arteries. Interactions between various concentrations of ADM and angiotensin II (Ang II) were studied, in the presence of L-NAME (a nitric oxide [NO] synthase inhibitor) and methylene blue (MB; a soluble guanylate cyclase inhibitor).
Results point out differences in the mechanism of the inhibitory action of ADM upon Ang II effects in the two vessel types studied. Inhibition of Ang II contraction by ADM involves guanylate cyclase in both cases. However, NO is involved in ADM-induced inhibition of angiotensinergic not in the resistance ones. vasoconstriction only in the conductance arteries, not in the resistance ones. |
| doi_str_mv | 10.3317/jraas.2004.014 |
| format | Article |
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The study uses the rat aorta ring as a model of conductance vessels, with or without vascular endothelium, and the second order branch of rat mesenteric arteries as a model of resistance arteries. Interactions between various concentrations of ADM and angiotensin II (Ang II) were studied, in the presence of L-NAME (a nitric oxide [NO] synthase inhibitor) and methylene blue (MB; a soluble guanylate cyclase inhibitor).
Results point out differences in the mechanism of the inhibitory action of ADM upon Ang II effects in the two vessel types studied. Inhibition of Ang II contraction by ADM involves guanylate cyclase in both cases. However, NO is involved in ADM-induced inhibition of angiotensinergic not in the resistance ones. vasoconstriction only in the conductance arteries, not in the resistance ones.</description><identifier>ISSN: 1470-3203</identifier><identifier>EISSN: 1752-8976</identifier><identifier>DOI: 10.3317/jraas.2004.014</identifier><identifier>PMID: 15295719</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adrenomedullin ; Angiotensin II - pharmacology ; Animals ; Aorta, Thoracic - drug effects ; Aorta, Thoracic - physiology ; Drug Interactions ; Enzyme Inhibitors - pharmacology ; In Vitro Techniques ; Male ; Mesenteric Arteries - drug effects ; Mesenteric Arteries - physiology ; NG-Nitroarginine Methyl Ester - pharmacology ; Peptides - pharmacology ; Phenylephrine - pharmacology ; Potassium - pharmacology ; Rats ; Rats, Wistar ; Vascular Resistance - drug effects ; Vasoconstriction - drug effects ; Vasoconstrictor Agents - pharmacology</subject><ispartof>Journal of the renin-angiotensin-aldosterone system, 2004-06, Vol.5 (2), p.79-83</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c327t-aba7bc9dfd8709e917baa4151353a6a51b8427042c91996a3b9b8af1846427233</citedby><cites>FETCH-LOGICAL-c327t-aba7bc9dfd8709e917baa4151353a6a51b8427042c91996a3b9b8af1846427233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15295719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haulica, Ion</creatorcontrib><creatorcontrib>Bild, Walther</creatorcontrib><creatorcontrib>Mihaila, Christian</creatorcontrib><creatorcontrib>Serban, Dragomir N</creatorcontrib><creatorcontrib>Serban, Lacramioara</creatorcontrib><creatorcontrib>Boisteanu, Daniela</creatorcontrib><creatorcontrib>Ionita, Teodor</creatorcontrib><creatorcontrib>Radasanu, Oana</creatorcontrib><title>Comparative study of the inhibitory effects of adrenomedullin on angiotensin II contraction in rat conductance and resistance arteries</title><title>Journal of the renin-angiotensin-aldosterone system</title><addtitle>J Renin Angiotensin Aldosterone Syst</addtitle><description>Adrenomedullin (ADM), a ubiquitous vasoactive peptide, has been the target of a multitude of studies concerning its effect on the vascular tone. The present work aims at clarifying a series of its interactions with the renin-angiotensin system.
The study uses the rat aorta ring as a model of conductance vessels, with or without vascular endothelium, and the second order branch of rat mesenteric arteries as a model of resistance arteries. Interactions between various concentrations of ADM and angiotensin II (Ang II) were studied, in the presence of L-NAME (a nitric oxide [NO] synthase inhibitor) and methylene blue (MB; a soluble guanylate cyclase inhibitor).
Results point out differences in the mechanism of the inhibitory action of ADM upon Ang II effects in the two vessel types studied. Inhibition of Ang II contraction by ADM involves guanylate cyclase in both cases. However, NO is involved in ADM-induced inhibition of angiotensinergic not in the resistance ones. vasoconstriction only in the conductance arteries, not in the resistance ones.</description><subject>Adrenomedullin</subject><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Aorta, Thoracic - drug effects</subject><subject>Aorta, Thoracic - physiology</subject><subject>Drug Interactions</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Mesenteric Arteries - drug effects</subject><subject>Mesenteric Arteries - physiology</subject><subject>NG-Nitroarginine Methyl Ester - pharmacology</subject><subject>Peptides - pharmacology</subject><subject>Phenylephrine - pharmacology</subject><subject>Potassium - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vascular Resistance - drug effects</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasoconstrictor Agents - pharmacology</subject><issn>1470-3203</issn><issn>1752-8976</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LAzEQhoMoVqtXj5K7bM3XbjZHKX4UCl70vMxms21Km5QkK_QP-LvN2oInTzPzzjsvzIPQHSUzzql83ASAOGOEiBmh4gxdUVmyolayOs-9kKTgjPAJuo5xQwivhWCXaEJLpkpJ1RX6nvvdHgIk-2VwTEN3wL7HaW2wdWvb2uTDAZu-NzrFcQNdMM7vTDdst9Zh7zC4lfXJuJjHxQJr71IAnWxeZSUnj1I36AROm-zucDDRxtMYkgnWxBt00cM2mttTnaLPl-eP-VuxfH9dzJ-WheZMpgJakK1WXd_VkiijqGwBBC0pLzlUUNK2FkwSwbSiSlXAW9XW0NNaVFlnnE_R7Jirg48xmL7ZB7uDcGgoaUagzS_QZgTaZKD54P54sB_a_PWf_UQwGx6Ohggr02z8EFx-4L-4H_KkgxU</recordid><startdate>20040601</startdate><enddate>20040601</enddate><creator>Haulica, Ion</creator><creator>Bild, Walther</creator><creator>Mihaila, Christian</creator><creator>Serban, Dragomir N</creator><creator>Serban, Lacramioara</creator><creator>Boisteanu, Daniela</creator><creator>Ionita, Teodor</creator><creator>Radasanu, Oana</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20040601</creationdate><title>Comparative study of the inhibitory effects of adrenomedullin on angiotensin II contraction in rat conductance and resistance arteries</title><author>Haulica, Ion ; Bild, Walther ; Mihaila, Christian ; Serban, Dragomir N ; Serban, Lacramioara ; Boisteanu, Daniela ; Ionita, Teodor ; Radasanu, Oana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-aba7bc9dfd8709e917baa4151353a6a51b8427042c91996a3b9b8af1846427233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adrenomedullin</topic><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Aorta, Thoracic - drug effects</topic><topic>Aorta, Thoracic - physiology</topic><topic>Drug Interactions</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Mesenteric Arteries - drug effects</topic><topic>Mesenteric Arteries - physiology</topic><topic>NG-Nitroarginine Methyl Ester - pharmacology</topic><topic>Peptides - pharmacology</topic><topic>Phenylephrine - pharmacology</topic><topic>Potassium - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vascular Resistance - drug effects</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasoconstrictor Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haulica, Ion</creatorcontrib><creatorcontrib>Bild, Walther</creatorcontrib><creatorcontrib>Mihaila, Christian</creatorcontrib><creatorcontrib>Serban, Dragomir N</creatorcontrib><creatorcontrib>Serban, Lacramioara</creatorcontrib><creatorcontrib>Boisteanu, Daniela</creatorcontrib><creatorcontrib>Ionita, Teodor</creatorcontrib><creatorcontrib>Radasanu, Oana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of the renin-angiotensin-aldosterone system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haulica, Ion</au><au>Bild, Walther</au><au>Mihaila, Christian</au><au>Serban, Dragomir N</au><au>Serban, Lacramioara</au><au>Boisteanu, Daniela</au><au>Ionita, Teodor</au><au>Radasanu, Oana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative study of the inhibitory effects of adrenomedullin on angiotensin II contraction in rat conductance and resistance arteries</atitle><jtitle>Journal of the renin-angiotensin-aldosterone system</jtitle><addtitle>J Renin Angiotensin Aldosterone Syst</addtitle><date>2004-06-01</date><risdate>2004</risdate><volume>5</volume><issue>2</issue><spage>79</spage><epage>83</epage><pages>79-83</pages><issn>1470-3203</issn><eissn>1752-8976</eissn><abstract>Adrenomedullin (ADM), a ubiquitous vasoactive peptide, has been the target of a multitude of studies concerning its effect on the vascular tone. The present work aims at clarifying a series of its interactions with the renin-angiotensin system.
The study uses the rat aorta ring as a model of conductance vessels, with or without vascular endothelium, and the second order branch of rat mesenteric arteries as a model of resistance arteries. Interactions between various concentrations of ADM and angiotensin II (Ang II) were studied, in the presence of L-NAME (a nitric oxide [NO] synthase inhibitor) and methylene blue (MB; a soluble guanylate cyclase inhibitor).
Results point out differences in the mechanism of the inhibitory action of ADM upon Ang II effects in the two vessel types studied. Inhibition of Ang II contraction by ADM involves guanylate cyclase in both cases. However, NO is involved in ADM-induced inhibition of angiotensinergic not in the resistance ones. vasoconstriction only in the conductance arteries, not in the resistance ones.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>15295719</pmid><doi>10.3317/jraas.2004.014</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adrenomedullin Angiotensin II - pharmacology Animals Aorta, Thoracic - drug effects Aorta, Thoracic - physiology Drug Interactions Enzyme Inhibitors - pharmacology In Vitro Techniques Male Mesenteric Arteries - drug effects Mesenteric Arteries - physiology NG-Nitroarginine Methyl Ester - pharmacology Peptides - pharmacology Phenylephrine - pharmacology Potassium - pharmacology Rats Rats, Wistar Vascular Resistance - drug effects Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology |
| title | Comparative study of the inhibitory effects of adrenomedullin on angiotensin II contraction in rat conductance and resistance arteries |
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