Renin-angiotensin blockade improves renal cGMP production via non-AT2-receptor mediated mechanisms in hypertension-induced by chronic NOS inhibition in rat

Background To investigate the changes in the angiotensin II (Ang II) receptors and nitric oxide (NO)-cGMP pathway in the rat kidney after nitric oxide synthase (NOS) blockade. Methods Captopril, an angiotensin-converting enzyme (ACE) inhibitor, 20 mg/100 ml; and/or L-158,809 (an Ang II AT 1-receptor...

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Veröffentlicht in:Journal of the renin-angiotensin-aldosterone system 2001-12, Vol.2 (4), p.233-239
Hauptverfasser: Uhlenius, Nina, Vuolteenaho, Olli, Tikkanen, Ilkka
Format: Artikel
Sprache:eng
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