Affinity of Luliconazole for Human Nail Derived Keratin

Affinity of Luliconazole (LLCZ), an antifungal drug used for topical treatment of onychomycosis in Japan, to nail keratin was demonstrated. Efinaconazole (EFCZ) was used as a reference drug. Drugs at fixed concentrations were added to 4 ml of buffer solution containing 40 mg of nail keratin powder p...

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Veröffentlicht in:	Medical Mycology Journal 2017, Vol.58(4), pp.J113-J119
Hauptverfasser:	Hasuko, Masayuki, Shiomi, Ryo, Takahashi, Yoshinori, Motoba, Kazuhiko, Hirano, Hirofumi, Tsuboi, Ryoji, Inagaki, Katsuhiro
Format:	Artikel
Sprache:	eng ; jpn
Schlagworte:	affinity to nail keratin efinaconazole freundlich isotherm healthy volunteers Humans Imidazoles - pharmacokinetics Keratins - metabolism luliconazole Nails - metabolism Onychomycosis - metabolism tinea unguium patients Triazoles - pharmacokinetics
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