The investigation of serum nectin-4 levels in patients with early onset preeclampsia

The investigation of serum nectin-4 levels in patients with early onset preeclampsia

Aims: We aimed to investigate the level and predictive value of soluble nectin-4 in early onset preeclampsia (EOPE). Methods: Forty-three patients with EOPE and 41 healthy normotensive pregnant women participated in this prospective case-control study. The groups were matched for gestational age and...

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Veröffentlicht in:Journal of health sciences and medicine : (Turkey) 2023-10, Vol.6 (6), p.1193-1199
Hauptverfasser: ACAR, Züat, OBUT, Mehmet, GEDİK ÖZKÖSE, Zeynep, SUCU, Sadun, SEZER, Salim, BUCAK, Mevlüt, DAĞ, İsmail, ERCİYESTEPE, Sezgi Güllü, ÖZDEMİR, İsmail
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container_issue 6
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container_title Journal of health sciences and medicine : (Turkey)
container_volume 6
creator ACAR, Züat
OBUT, Mehmet
GEDİK ÖZKÖSE, Zeynep
SUCU, Sadun
SEZER, Salim
BUCAK, Mevlüt
DAĞ, İsmail
ERCİYESTEPE, Sezgi Güllü
ÖZDEMİR, İsmail
description Aims: We aimed to investigate the level and predictive value of soluble nectin-4 in early onset preeclampsia (EOPE). Methods: Forty-three patients with EOPE and 41 healthy normotensive pregnant women participated in this prospective case-control study. The groups were matched for gestational age and gravidity. Serum nectin-4 levels were compared between groups. The ROC curve was drawn to show the predictive value of nectin-4 for EOPE. Patients were followed up until the end of labor, and perinatal outcomes were recorded. Results: The demographic characteristics of the two groups were similar. Serum nectin-4 level was significantly increased in EOPE cases compared to controls (226.46±119.6 ng/ml vs. 156.54±44.8 ng/ml, p=0.001). The ROC showed that at > 160.938, the sensitivity and specificity were 67.44% and 82.93%, respectively [AUC:0.822, (CI:0.724 - 0.897), and (p< 0.001)]. Significant inverse correlations were found between nectin-4 levels and poor obstetric outcomes. Conclusion: Maternal serum nectin-4 levels were significantly higher in patients with EOPE compared with controls. Increased nectin-4 levels may contribute to the development of EOPE through possible oxidative, immunological, and inflammatory mechanisms adversely affecting trophoblastic cells.
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Methods: Forty-three patients with EOPE and 41 healthy normotensive pregnant women participated in this prospective case-control study. The groups were matched for gestational age and gravidity. Serum nectin-4 levels were compared between groups. The ROC curve was drawn to show the predictive value of nectin-4 for EOPE. Patients were followed up until the end of labor, and perinatal outcomes were recorded. Results: The demographic characteristics of the two groups were similar. Serum nectin-4 level was significantly increased in EOPE cases compared to controls (226.46±119.6 ng/ml vs. 156.54±44.8 ng/ml, p=0.001). The ROC showed that at &gt; 160.938, the sensitivity and specificity were 67.44% and 82.93%, respectively [AUC:0.822, (CI:0.724 - 0.897), and (p&lt; 0.001)]. Significant inverse correlations were found between nectin-4 levels and poor obstetric outcomes. Conclusion: Maternal serum nectin-4 levels were significantly higher in patients with EOPE compared with controls. 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title The investigation of serum nectin-4 levels in patients with early onset preeclampsia
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