Molecular detection of epstein barr virus in women with breast cancer
Background : epstein Barr Virus (EBV) infection has been implicated in pathogenesis of several types of carcinomas such as nasopharyngeal carcinoma, gastric cancer and bladder cancer and has recently been associated with breast cancer. Objective : to evaluate the relations between Epstein Barr virus...
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| Veröffentlicht in: | Journal of the Faculty of Medicine, Baghdad Baghdad, 2013-07, Vol.55 (2), p.144-148 |
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| container_title | Journal of the Faculty of Medicine, Baghdad |
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| creator | Husayn, Arij A. |
| description | Background : epstein Barr Virus (EBV) infection has been implicated in pathogenesis of several types of carcinomas such as nasopharyngeal carcinoma, gastric cancer and bladder cancer and has recently been associated with breast cancer.
Objective : to evaluate the relations between Epstein Barr virus-encoded small RNA (EBER) and breast cancer.
Methods : Twenty two cases of breast cancer were retrieved from the Al-Kadhimiya Teaching Hospital in Baghdad. Clinical data were analyzed from the medical records and formalin fixed, paraffin embedded tumor tissue were examined by Chromogeneic in situ hybridization (ISH) technique for the detection of EBER.
Results : the expression of EBER in tissues patients with breast cancer in the present study was 50 % (11 out of 22), where strong correlation was found between expression of EBER and patients with breast cancer. While not found significant differences between ISH expressions of EBER with age, type of cancer, grade and lymph node metastasis.
Conclusion : based on the results of the current study, Epstein Barr virus infection plays a major role in the pathogenesis of breast cancer. |
| doi_str_mv | 10.32007/jfacmedbagdad.552643 |
| format | Article |
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Objective : to evaluate the relations between Epstein Barr virus-encoded small RNA (EBER) and breast cancer.
Methods : Twenty two cases of breast cancer were retrieved from the Al-Kadhimiya Teaching Hospital in Baghdad. Clinical data were analyzed from the medical records and formalin fixed, paraffin embedded tumor tissue were examined by Chromogeneic in situ hybridization (ISH) technique for the detection of EBER.
Results : the expression of EBER in tissues patients with breast cancer in the present study was 50 % (11 out of 22), where strong correlation was found between expression of EBER and patients with breast cancer. While not found significant differences between ISH expressions of EBER with age, type of cancer, grade and lymph node metastasis.
Conclusion : based on the results of the current study, Epstein Barr virus infection plays a major role in the pathogenesis of breast cancer.</description><identifier>ISSN: 0041-9419</identifier><identifier>EISSN: 2410-8057</identifier><identifier>DOI: 10.32007/jfacmedbagdad.552643</identifier><language>eng</language><publisher>Baghdad, Iraq: University of Baghdad, Faculty of Medicine</publisher><subject>Breast ; Cancer ; Epstein-Barr virus diseases ; Molecular aspects ; الثدي ; السرطان</subject><ispartof>Journal of the Faculty of Medicine, Baghdad, 2013-07, Vol.55 (2), p.144-148</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Husayn, Arij A.</creatorcontrib><title>Molecular detection of epstein barr virus in women with breast cancer</title><title>Journal of the Faculty of Medicine, Baghdad</title><description>Background : epstein Barr Virus (EBV) infection has been implicated in pathogenesis of several types of carcinomas such as nasopharyngeal carcinoma, gastric cancer and bladder cancer and has recently been associated with breast cancer.
Objective : to evaluate the relations between Epstein Barr virus-encoded small RNA (EBER) and breast cancer.
Methods : Twenty two cases of breast cancer were retrieved from the Al-Kadhimiya Teaching Hospital in Baghdad. Clinical data were analyzed from the medical records and formalin fixed, paraffin embedded tumor tissue were examined by Chromogeneic in situ hybridization (ISH) technique for the detection of EBER.
Results : the expression of EBER in tissues patients with breast cancer in the present study was 50 % (11 out of 22), where strong correlation was found between expression of EBER and patients with breast cancer. While not found significant differences between ISH expressions of EBER with age, type of cancer, grade and lymph node metastasis.
Conclusion : based on the results of the current study, Epstein Barr virus infection plays a major role in the pathogenesis of breast cancer.</description><subject>Breast</subject><subject>Cancer</subject><subject>Epstein-Barr virus diseases</subject><subject>Molecular aspects</subject><subject>الثدي</subject><subject>السرطان</subject><issn>0041-9419</issn><issn>2410-8057</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNpVkN1KAzEQhYMoWGofoZAX2Jpkkk1yKaX-QMWb3i9JdqJbursl2Sq-vcGK0LmY4QzzHYZDyJKzFQjG9P0-utBj691769qVUqKWcEVmQnJWGab0NZkxJnllJbe3ZJHznpUyZWfkjGxexwOG08El2uKEYerGgY6R4jFP2A3Uu5ToZ5dOmRb1NfZYejd9UJ_Q5YkGNwRMd-QmukPGxd-ck93jZrd-rrZvTy_rh20ValO-iQpkNByN55bZaHwQXps2Bh2Z9EYDrxU3VmN0yMGCgsClt6CjsCgCzIk624Y05pwwNsfU9S59N5w1v2k0F2k05zQKtzxzWI6L-T8GUAvN4AfkeWBk</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Husayn, Arij A.</creator><general>University of Baghdad, Faculty of Medicine</general><scope>ADJCN</scope><scope>AFFIF</scope><scope>AHFXO</scope><scope>AHHHR</scope><scope>AHQOB</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20130701</creationdate><title>Molecular detection of epstein barr virus in women with breast cancer</title><author>Husayn, Arij A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c680-8f534f81e8b1909f8bc2b78dfc7f04b8731651897efae139353c14b937f29e2c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Breast</topic><topic>Cancer</topic><topic>Epstein-Barr virus diseases</topic><topic>Molecular aspects</topic><topic>الثدي</topic><topic>السرطان</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Husayn, Arij A.</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>قاعدة دراسات المرأة - e-Marefa Women Studies</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>دراسات الشرق الأوسط - e-Marefa Middle Eastern Studies</collection><collection>الشؤون الدولية والعربية - e-Marefa International & Arab Affairs</collection><collection>CrossRef</collection><jtitle>Journal of the Faculty of Medicine, Baghdad</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Husayn, Arij A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular detection of epstein barr virus in women with breast cancer</atitle><jtitle>Journal of the Faculty of Medicine, Baghdad</jtitle><date>2013-07-01</date><risdate>2013</risdate><volume>55</volume><issue>2</issue><spage>144</spage><epage>148</epage><pages>144-148</pages><issn>0041-9419</issn><eissn>2410-8057</eissn><abstract>Background : epstein Barr Virus (EBV) infection has been implicated in pathogenesis of several types of carcinomas such as nasopharyngeal carcinoma, gastric cancer and bladder cancer and has recently been associated with breast cancer.
Objective : to evaluate the relations between Epstein Barr virus-encoded small RNA (EBER) and breast cancer.
Methods : Twenty two cases of breast cancer were retrieved from the Al-Kadhimiya Teaching Hospital in Baghdad. Clinical data were analyzed from the medical records and formalin fixed, paraffin embedded tumor tissue were examined by Chromogeneic in situ hybridization (ISH) technique for the detection of EBER.
Results : the expression of EBER in tissues patients with breast cancer in the present study was 50 % (11 out of 22), where strong correlation was found between expression of EBER and patients with breast cancer. While not found significant differences between ISH expressions of EBER with age, type of cancer, grade and lymph node metastasis.
Conclusion : based on the results of the current study, Epstein Barr virus infection plays a major role in the pathogenesis of breast cancer.</abstract><cop>Baghdad, Iraq</cop><pub>University of Baghdad, Faculty of Medicine</pub><doi>10.32007/jfacmedbagdad.552643</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of the Faculty of Medicine, Baghdad, 2013-07, Vol.55 (2), p.144-148 |
| issn | 0041-9419 2410-8057 |
| language | eng |
| recordid | cdi_crossref_primary_10_32007_jfacmedbagdad_552643 |
| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Breast Cancer Epstein-Barr virus diseases Molecular aspects الثدي السرطان |
| title | Molecular detection of epstein barr virus in women with breast cancer |
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