Anti-obesity effect of Microalga, Melosira nummuloieds ethanolic extract in high-fat-diet-induced obesity C57BL/6J mice

Anti-obesity effect of Microalga, Melosira nummuloieds ethanolic extract in high-fat-diet-induced obesity C57BL/6J mice

Background: Melosira nummuloides is a microalga belonging to the Melosiracease diatom. The ability of the diatoms to mass-produce essential fatty acids and carotenoid pigments was reported, which has driven research and their industrial application. Melosira nummuloides mass-cultivated with Jeju Lav...

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Veröffentlicht in:Functional foods in health and disease 2022-12, Vol.12 (12), p.693
Hauptverfasser: Yun, Injue, Choi, Jiwon, Choe, Hyeonjeong, Kim, Ki-ok, Go, Gyung Min, Lee, Dae-Hee, Kim, Mi-Yeon
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container_issue 12
container_start_page 693
container_title Functional foods in health and disease
container_volume 12
creator Yun, Injue
Choi, Jiwon
Choe, Hyeonjeong
Kim, Ki-ok
Go, Gyung Min
Lee, Dae-Hee
Kim, Mi-Yeon
description Background: Melosira nummuloides is a microalga belonging to the Melosiracease diatom. The ability of the diatoms to mass-produce essential fatty acids and carotenoid pigments was reported, which has driven research and their industrial application. Melosira nummuloides mass-cultivated with Jeju Lava sea water contains fucoxanthin, which has excellent biological properties such as antioxidant, anti-inflammatory, anti-cancer, and anti-obesity activities. The effect of M. nummuloides ethanolic extract (MEE) on the reduction of fat accumulation was evaluated.Methods: C57BL/6J mice fed a high-fat diet (HFD) were treated over 8 weeks with Melosira ethanolic extract. Cholesterol in serum and triglyceride in liver after the 8-week were evaluated. The expression of SREBP-1c, FAS, PPAR-γ, SCD-1 and p-AMPK were measured by western blotting respectively.Results: The MEE-treated C57BL/6J showed significant body weight and visceral fat loss compared to HFD group. Cholesterol in serum and triglyceride levels in liver showed a significant decrease in MEE groups. Levels of SREBP-1c, FAS, PPAR-γ and SCD-1 were low in mice fed an HFD+MEE.Conclusion: These results show MEE reduces blood lipid levels by regulating the expression of factors related to lipid synthesis and adipocyte differentiation in adipose tissue and inhibiting new lipid synthesis in the liver. M. nummuloides ethanolic extract confirmed its suitability as an anti-obesity agent.Keywords: Melosira nummuloides; C57BL/6J mice; obesity: weight loss; fatty acid synthesis
doi_str_mv 10.31989/ffhd.v12i12.1002
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The ability of the diatoms to mass-produce essential fatty acids and carotenoid pigments was reported, which has driven research and their industrial application. Melosira nummuloides mass-cultivated with Jeju Lava sea water contains fucoxanthin, which has excellent biological properties such as antioxidant, anti-inflammatory, anti-cancer, and anti-obesity activities. The effect of M. nummuloides ethanolic extract (MEE) on the reduction of fat accumulation was evaluated.Methods: C57BL/6J mice fed a high-fat diet (HFD) were treated over 8 weeks with Melosira ethanolic extract. Cholesterol in serum and triglyceride in liver after the 8-week were evaluated. The expression of SREBP-1c, FAS, PPAR-γ, SCD-1 and p-AMPK were measured by western blotting respectively.Results: The MEE-treated C57BL/6J showed significant body weight and visceral fat loss compared to HFD group. Cholesterol in serum and triglyceride levels in liver showed a significant decrease in MEE groups. Levels of SREBP-1c, FAS, PPAR-γ and SCD-1 were low in mice fed an HFD+MEE.Conclusion: These results show MEE reduces blood lipid levels by regulating the expression of factors related to lipid synthesis and adipocyte differentiation in adipose tissue and inhibiting new lipid synthesis in the liver. M. nummuloides ethanolic extract confirmed its suitability as an anti-obesity agent.Keywords: Melosira nummuloides; C57BL/6J mice; obesity: weight loss; fatty acid synthesis</description><identifier>ISSN: 2378-7007</identifier><identifier>EISSN: 2160-3855</identifier><identifier>DOI: 10.31989/ffhd.v12i12.1002</identifier><language>eng</language><ispartof>Functional foods in health and disease, 2022-12, Vol.12 (12), p.693</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c160t-10d07cfb64be4669d860bca5ad8992c952bcd2cff91530b6355a0a4f47e129cd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Yun, Injue</creatorcontrib><creatorcontrib>Choi, Jiwon</creatorcontrib><creatorcontrib>Choe, Hyeonjeong</creatorcontrib><creatorcontrib>Kim, Ki-ok</creatorcontrib><creatorcontrib>Go, Gyung Min</creatorcontrib><creatorcontrib>Lee, Dae-Hee</creatorcontrib><creatorcontrib>Kim, Mi-Yeon</creatorcontrib><title>Anti-obesity effect of Microalga, Melosira nummuloieds ethanolic extract in high-fat-diet-induced obesity C57BL/6J mice</title><title>Functional foods in health and disease</title><description>Background: Melosira nummuloides is a microalga belonging to the Melosiracease diatom. The ability of the diatoms to mass-produce essential fatty acids and carotenoid pigments was reported, which has driven research and their industrial application. Melosira nummuloides mass-cultivated with Jeju Lava sea water contains fucoxanthin, which has excellent biological properties such as antioxidant, anti-inflammatory, anti-cancer, and anti-obesity activities. The effect of M. nummuloides ethanolic extract (MEE) on the reduction of fat accumulation was evaluated.Methods: C57BL/6J mice fed a high-fat diet (HFD) were treated over 8 weeks with Melosira ethanolic extract. Cholesterol in serum and triglyceride in liver after the 8-week were evaluated. The expression of SREBP-1c, FAS, PPAR-γ, SCD-1 and p-AMPK were measured by western blotting respectively.Results: The MEE-treated C57BL/6J showed significant body weight and visceral fat loss compared to HFD group. Cholesterol in serum and triglyceride levels in liver showed a significant decrease in MEE groups. Levels of SREBP-1c, FAS, PPAR-γ and SCD-1 were low in mice fed an HFD+MEE.Conclusion: These results show MEE reduces blood lipid levels by regulating the expression of factors related to lipid synthesis and adipocyte differentiation in adipose tissue and inhibiting new lipid synthesis in the liver. 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The ability of the diatoms to mass-produce essential fatty acids and carotenoid pigments was reported, which has driven research and their industrial application. Melosira nummuloides mass-cultivated with Jeju Lava sea water contains fucoxanthin, which has excellent biological properties such as antioxidant, anti-inflammatory, anti-cancer, and anti-obesity activities. The effect of M. nummuloides ethanolic extract (MEE) on the reduction of fat accumulation was evaluated.Methods: C57BL/6J mice fed a high-fat diet (HFD) were treated over 8 weeks with Melosira ethanolic extract. Cholesterol in serum and triglyceride in liver after the 8-week were evaluated. The expression of SREBP-1c, FAS, PPAR-γ, SCD-1 and p-AMPK were measured by western blotting respectively.Results: The MEE-treated C57BL/6J showed significant body weight and visceral fat loss compared to HFD group. Cholesterol in serum and triglyceride levels in liver showed a significant decrease in MEE groups. Levels of SREBP-1c, FAS, PPAR-γ and SCD-1 were low in mice fed an HFD+MEE.Conclusion: These results show MEE reduces blood lipid levels by regulating the expression of factors related to lipid synthesis and adipocyte differentiation in adipose tissue and inhibiting new lipid synthesis in the liver. M. nummuloides ethanolic extract confirmed its suitability as an anti-obesity agent.Keywords: Melosira nummuloides; C57BL/6J mice; obesity: weight loss; fatty acid synthesis</abstract><doi>10.31989/ffhd.v12i12.1002</doi></addata></record>
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