Effectiveness of Regional Hyperthermia Combined with Lamivudine in Treating Chronic Hepatitis B

Effectiveness of Regional Hyperthermia Combined with Lamivudine in Treating Chronic Hepatitis B

The aim of this study was to evaluate the effectiveness of regional hyperthermia combined with lamivudine (LAM) for treatment of chronic hepatitis B (CHB) and explore its possible mechanism. Forty CHB patients were randomly divided into the combination group (treated with regional hyperthermia and L...

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Veröffentlicht in:Thermal Medicine 2011/09/20, Vol.27(3), pp.61-68
Hauptverfasser: LIN, ZHANG, DENG-PING, SHI, WEN-TAO, YANG, BING, HU, ZHI-YING, WENG, JIAN-DONG, XI, SHAO-LIAN, JIANG, YA-MEI, KONG, WEN-WEN, LI
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chronic hepatitis B
lamivudine
regional hyperthermia
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container_end_page 68
container_issue 3
container_start_page 61
container_title Thermal Medicine
container_volume 27
creator LIN, ZHANG
DENG-PING, SHI
WEN-TAO, YANG
BING, HU
ZHI-YING, WENG
JIAN-DONG, XI
SHAO-LIAN, JIANG
YA-MEI, KONG
WEN-WEN, LI
description The aim of this study was to evaluate the effectiveness of regional hyperthermia combined with lamivudine (LAM) for treatment of chronic hepatitis B (CHB) and explore its possible mechanism. Forty CHB patients were randomly divided into the combination group (treated with regional hyperthermia and LAM ; n=17) and control group (treated with LAM alone ; n=23). Laboratory examinations were performed for hepatic function, hepatitis B virus (HBV) markers, and HBV DNA. Lymphocyte subpopulations including CD3+ (total T cells), CD4+CD8- (helper T cells) and CD4-CD8+ (cytotoxic T cells) were detected with flow cytometry. The side effects and tolerance were observed. Aspartate aminotransferase and HBV-DNA levels were significantly lower in the combination group than in the control group (P< 0.05). Hepatitis e antigen/antibody conversion rate was similar between the two groups, whereas the combination group had significantly higher rates of CD4+/CD8+ T cells than the control group (P< 0.05). Regional hyperthermia combined with LAM is superior to LAM alone for treatment of CHB, which may be achieved by enhancing cellular immune function.
doi_str_mv 10.3191/thermalmed.27.61
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Forty CHB patients were randomly divided into the combination group (treated with regional hyperthermia and LAM ; n=17) and control group (treated with LAM alone ; n=23). Laboratory examinations were performed for hepatic function, hepatitis B virus (HBV) markers, and HBV DNA. Lymphocyte subpopulations including CD3+ (total T cells), CD4+CD8- (helper T cells) and CD4-CD8+ (cytotoxic T cells) were detected with flow cytometry. The side effects and tolerance were observed. Aspartate aminotransferase and HBV-DNA levels were significantly lower in the combination group than in the control group (P&lt; 0.05). Hepatitis e antigen/antibody conversion rate was similar between the two groups, whereas the combination group had significantly higher rates of CD4+/CD8+ T cells than the control group (P&lt; 0.05). 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source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese
subjects chronic hepatitis B
lamivudine
regional hyperthermia
title Effectiveness of Regional Hyperthermia Combined with Lamivudine in Treating Chronic Hepatitis B
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