Effectiveness of Regional Hyperthermia Combined with Lamivudine in Treating Chronic Hepatitis B
The aim of this study was to evaluate the effectiveness of regional hyperthermia combined with lamivudine (LAM) for treatment of chronic hepatitis B (CHB) and explore its possible mechanism. Forty CHB patients were randomly divided into the combination group (treated with regional hyperthermia and L...
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Veröffentlicht in: | Thermal Medicine 2011/09/20, Vol.27(3), pp.61-68 |
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creator | LIN, ZHANG DENG-PING, SHI WEN-TAO, YANG BING, HU ZHI-YING, WENG JIAN-DONG, XI SHAO-LIAN, JIANG YA-MEI, KONG WEN-WEN, LI |
description | The aim of this study was to evaluate the effectiveness of regional hyperthermia combined with lamivudine (LAM) for treatment of chronic hepatitis B (CHB) and explore its possible mechanism. Forty CHB patients were randomly divided into the combination group (treated with regional hyperthermia and LAM ; n=17) and control group (treated with LAM alone ; n=23). Laboratory examinations were performed for hepatic function, hepatitis B virus (HBV) markers, and HBV DNA. Lymphocyte subpopulations including CD3+ (total T cells), CD4+CD8- (helper T cells) and CD4-CD8+ (cytotoxic T cells) were detected with flow cytometry. The side effects and tolerance were observed. Aspartate aminotransferase and HBV-DNA levels were significantly lower in the combination group than in the control group (P< 0.05). Hepatitis e antigen/antibody conversion rate was similar between the two groups, whereas the combination group had significantly higher rates of CD4+/CD8+ T cells than the control group (P< 0.05). Regional hyperthermia combined with LAM is superior to LAM alone for treatment of CHB, which may be achieved by enhancing cellular immune function. |
doi_str_mv | 10.3191/thermalmed.27.61 |
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Forty CHB patients were randomly divided into the combination group (treated with regional hyperthermia and LAM ; n=17) and control group (treated with LAM alone ; n=23). Laboratory examinations were performed for hepatic function, hepatitis B virus (HBV) markers, and HBV DNA. Lymphocyte subpopulations including CD3+ (total T cells), CD4+CD8- (helper T cells) and CD4-CD8+ (cytotoxic T cells) were detected with flow cytometry. The side effects and tolerance were observed. Aspartate aminotransferase and HBV-DNA levels were significantly lower in the combination group than in the control group (P< 0.05). Hepatitis e antigen/antibody conversion rate was similar between the two groups, whereas the combination group had significantly higher rates of CD4+/CD8+ T cells than the control group (P< 0.05). Regional hyperthermia combined with LAM is superior to LAM alone for treatment of CHB, which may be achieved by enhancing cellular immune function.</description><identifier>ISSN: 1882-2576</identifier><identifier>EISSN: 1882-3750</identifier><identifier>DOI: 10.3191/thermalmed.27.61</identifier><language>eng</language><publisher>Japanese Society for Thermal Medicine</publisher><subject>chronic hepatitis B ; lamivudine ; regional hyperthermia</subject><ispartof>Thermal Medicine, 2011/09/20, Vol.27(3), pp.61-68</ispartof><rights>2011 Japanese Society for Thermal Medicine</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2351-79d00c61fa2bf75b3e28bc32219a8666870bb458fd59c38947f2b2b89084c3be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,1885,27931,27932</link.rule.ids></links><search><creatorcontrib>LIN, ZHANG</creatorcontrib><creatorcontrib>DENG-PING, SHI</creatorcontrib><creatorcontrib>WEN-TAO, YANG</creatorcontrib><creatorcontrib>BING, HU</creatorcontrib><creatorcontrib>ZHI-YING, WENG</creatorcontrib><creatorcontrib>JIAN-DONG, XI</creatorcontrib><creatorcontrib>SHAO-LIAN, JIANG</creatorcontrib><creatorcontrib>YA-MEI, KONG</creatorcontrib><creatorcontrib>WEN-WEN, LI</creatorcontrib><title>Effectiveness of Regional Hyperthermia Combined with Lamivudine in Treating Chronic Hepatitis B</title><title>Thermal Medicine</title><addtitle>Thermal Med.</addtitle><description>The aim of this study was to evaluate the effectiveness of regional hyperthermia combined with lamivudine (LAM) for treatment of chronic hepatitis B (CHB) and explore its possible mechanism. Forty CHB patients were randomly divided into the combination group (treated with regional hyperthermia and LAM ; n=17) and control group (treated with LAM alone ; n=23). Laboratory examinations were performed for hepatic function, hepatitis B virus (HBV) markers, and HBV DNA. Lymphocyte subpopulations including CD3+ (total T cells), CD4+CD8- (helper T cells) and CD4-CD8+ (cytotoxic T cells) were detected with flow cytometry. The side effects and tolerance were observed. Aspartate aminotransferase and HBV-DNA levels were significantly lower in the combination group than in the control group (P< 0.05). Hepatitis e antigen/antibody conversion rate was similar between the two groups, whereas the combination group had significantly higher rates of CD4+/CD8+ T cells than the control group (P< 0.05). Regional hyperthermia combined with LAM is superior to LAM alone for treatment of CHB, which may be achieved by enhancing cellular immune function.</description><subject>chronic hepatitis B</subject><subject>lamivudine</subject><subject>regional hyperthermia</subject><issn>1882-2576</issn><issn>1882-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNpdkEtLAzEUhYMoWKt7l_kDU_OYSTJLHaoVCoLUdUgyN52UeZRkrPTfW22p4Obcw7l8Z3EQuqdkxmlJH8YGYmfaDuoZkzNBL9CEKsUyLgtyefKskOIa3aS0IURQSfIJ0nPvwY1hBz2khAeP32Edht60eLHfQvytDQZXQ2dDDzX-CmODl6YLu8_6EODQ41UEM4Z-jasmDn1weAHbQzCGhJ9u0ZU3bYK7052ij-f5qlpky7eX1-pxmTnGC5rJsibECeoNs14WlgNT1nHGaGmUEEJJYm1eKF8XpeOqzKVnlllVEpU7boFPETn2ujikFMHrbQydiXtNif4ZSP8NpJnUgh6Q-RHZpNGs4QyYOAbXwj-AH0XQ8981Jmro-TfdTHbE</recordid><startdate>20110920</startdate><enddate>20110920</enddate><creator>LIN, ZHANG</creator><creator>DENG-PING, SHI</creator><creator>WEN-TAO, YANG</creator><creator>BING, HU</creator><creator>ZHI-YING, WENG</creator><creator>JIAN-DONG, XI</creator><creator>SHAO-LIAN, JIANG</creator><creator>YA-MEI, KONG</creator><creator>WEN-WEN, LI</creator><general>Japanese Society for Thermal Medicine</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20110920</creationdate><title>Effectiveness of Regional Hyperthermia Combined with Lamivudine in Treating Chronic Hepatitis B</title><author>LIN, ZHANG ; DENG-PING, SHI ; WEN-TAO, YANG ; BING, HU ; ZHI-YING, WENG ; JIAN-DONG, XI ; SHAO-LIAN, JIANG ; YA-MEI, KONG ; WEN-WEN, LI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2351-79d00c61fa2bf75b3e28bc32219a8666870bb458fd59c38947f2b2b89084c3be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>chronic hepatitis B</topic><topic>lamivudine</topic><topic>regional hyperthermia</topic><toplevel>online_resources</toplevel><creatorcontrib>LIN, ZHANG</creatorcontrib><creatorcontrib>DENG-PING, SHI</creatorcontrib><creatorcontrib>WEN-TAO, YANG</creatorcontrib><creatorcontrib>BING, HU</creatorcontrib><creatorcontrib>ZHI-YING, WENG</creatorcontrib><creatorcontrib>JIAN-DONG, XI</creatorcontrib><creatorcontrib>SHAO-LIAN, JIANG</creatorcontrib><creatorcontrib>YA-MEI, KONG</creatorcontrib><creatorcontrib>WEN-WEN, LI</creatorcontrib><collection>CrossRef</collection><jtitle>Thermal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LIN, ZHANG</au><au>DENG-PING, SHI</au><au>WEN-TAO, YANG</au><au>BING, HU</au><au>ZHI-YING, WENG</au><au>JIAN-DONG, XI</au><au>SHAO-LIAN, JIANG</au><au>YA-MEI, KONG</au><au>WEN-WEN, LI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of Regional Hyperthermia Combined with Lamivudine in Treating Chronic Hepatitis B</atitle><jtitle>Thermal Medicine</jtitle><addtitle>Thermal Med.</addtitle><date>2011-09-20</date><risdate>2011</risdate><volume>27</volume><issue>3</issue><spage>61</spage><epage>68</epage><pages>61-68</pages><issn>1882-2576</issn><eissn>1882-3750</eissn><abstract>The aim of this study was to evaluate the effectiveness of regional hyperthermia combined with lamivudine (LAM) for treatment of chronic hepatitis B (CHB) and explore its possible mechanism. Forty CHB patients were randomly divided into the combination group (treated with regional hyperthermia and LAM ; n=17) and control group (treated with LAM alone ; n=23). Laboratory examinations were performed for hepatic function, hepatitis B virus (HBV) markers, and HBV DNA. Lymphocyte subpopulations including CD3+ (total T cells), CD4+CD8- (helper T cells) and CD4-CD8+ (cytotoxic T cells) were detected with flow cytometry. The side effects and tolerance were observed. Aspartate aminotransferase and HBV-DNA levels were significantly lower in the combination group than in the control group (P< 0.05). Hepatitis e antigen/antibody conversion rate was similar between the two groups, whereas the combination group had significantly higher rates of CD4+/CD8+ T cells than the control group (P< 0.05). Regional hyperthermia combined with LAM is superior to LAM alone for treatment of CHB, which may be achieved by enhancing cellular immune function.</abstract><pub>Japanese Society for Thermal Medicine</pub><doi>10.3191/thermalmed.27.61</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
subjects | chronic hepatitis B lamivudine regional hyperthermia |
title | Effectiveness of Regional Hyperthermia Combined with Lamivudine in Treating Chronic Hepatitis B |
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