Investigating Anti-Obesity Effects by Oral Administration of Aloe vera Gel Extract (AVGE): Possible Involvement in Activation of Brown Adipose Tissue (BAT)
The aim of this study is to investigate the mechanism of anti-obesity effects of Aloe vera gel extract (AVGE) containing Aloe sterols. Previously, we reported that oral intake of Aloe vera components has an anti-diabetic and anti-obesity effect. This study was designed to assess the role of brown ad...
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| Veröffentlicht in: | Journal of Nutritional Science and Vitaminology 2020/04/30, Vol.66(2), pp.176-184 |
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| creator | TADA, Asuka MISAWA, Eriko TANAKA, Miyuki SAITO, Marie NABESHIMA, Kazumi YAMAUCHI, Koji ABE, Fumiaki GOTO, Tsuyoshi KAWADA, Teruo |
| description | The aim of this study is to investigate the mechanism of anti-obesity effects of Aloe vera gel extract (AVGE) containing Aloe sterols. Previously, we reported that oral intake of Aloe vera components has an anti-diabetic and anti-obesity effect. This study was designed to assess the role of brown adipose tissue (BAT) in the anti-obesity effect of AVGE. Six-week-old male mice were divided into three groups; STD (standard diet), HFD (60% high fat diet) and AVGE (60% high fat diet with AVGE treatment). During 11 wk of AVGE administration, body weight has been monitored. Tissue samples were obtained to be measured the weight and evaluated the gene expressions. Mice treated with AVGE had suppressed body weight, and liver and fat weight gain. To investigate BAT activation, we measured the expression of mRNA related to BAT thermogenesis. Mice in the AVGE group had higher expression of Ucp1, Adrb3, and Cidea in BAT compared to HFD. Next, to investigate the possibility that AVGE induced hepatic FGF21, which is an important factor for nutrient and energy homeostasis including BAT regulation, in vitro study was conducted. HepG2 cell stimulated by AVGE were highly expressed FGF21. These results suggested that BAT activation partially contributes to mechanism of anti-obesity effect of Aloe sterols in diet-induced obesity (DIO) models. However, further study is needed to determine the predominant mechanism. |
| doi_str_mv | 10.3177/jnsv.66.176 |
| format | Article |
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Previously, we reported that oral intake of Aloe vera components has an anti-diabetic and anti-obesity effect. This study was designed to assess the role of brown adipose tissue (BAT) in the anti-obesity effect of AVGE. Six-week-old male mice were divided into three groups; STD (standard diet), HFD (60% high fat diet) and AVGE (60% high fat diet with AVGE treatment). During 11 wk of AVGE administration, body weight has been monitored. Tissue samples were obtained to be measured the weight and evaluated the gene expressions. Mice treated with AVGE had suppressed body weight, and liver and fat weight gain. To investigate BAT activation, we measured the expression of mRNA related to BAT thermogenesis. Mice in the AVGE group had higher expression of Ucp1, Adrb3, and Cidea in BAT compared to HFD. Next, to investigate the possibility that AVGE induced hepatic FGF21, which is an important factor for nutrient and energy homeostasis including BAT regulation, in vitro study was conducted. HepG2 cell stimulated by AVGE were highly expressed FGF21. These results suggested that BAT activation partially contributes to mechanism of anti-obesity effect of Aloe sterols in diet-induced obesity (DIO) models. However, further study is needed to determine the predominant mechanism.</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.66.176</identifier><identifier>PMID: 32350179</identifier><language>eng</language><publisher>Japan: Center for Academic Publications Japan</publisher><subject>Adipose Tissue, Brown - drug effects ; Adipose Tissue, Brown - metabolism ; Administration, Oral ; Aloe - chemistry ; Aloe sterols ; Animals ; Anti-Obesity Agents - pharmacology ; Anti-Obesity Agents - therapeutic use ; Diet, High-Fat - adverse effects ; Dietary Fats - administration & dosage ; Dietary Fats - adverse effects ; DIO ; Energy Metabolism ; FGF21 ; Fibroblast Growth Factors - metabolism ; Hep G2 Cells ; Humans ; Liver - drug effects ; Liver - metabolism ; Male ; Mice, Inbred C57BL ; Obesity - etiology ; Obesity - metabolism ; Obesity - prevention & control ; Phytosterols - pharmacology ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Preparations - chemistry ; Plant Preparations - pharmacology ; Plant Preparations - therapeutic use ; PPAR ; Thermogenesis - drug effects ; UCP ; Weight Gain - drug effects</subject><ispartof>Journal of Nutritional Science and Vitaminology, 2020/04/30, Vol.66(2), pp.176-184</ispartof><rights>2020 by the Center for Academic Publications Japan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-f4e482bd8564737ac5599d659bae5b94bb32ee5724a3d2bd5affd00537d2ce9f3</citedby><cites>FETCH-LOGICAL-c555t-f4e482bd8564737ac5599d659bae5b94bb32ee5724a3d2bd5affd00537d2ce9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32350179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TADA, Asuka</creatorcontrib><creatorcontrib>MISAWA, Eriko</creatorcontrib><creatorcontrib>TANAKA, Miyuki</creatorcontrib><creatorcontrib>SAITO, Marie</creatorcontrib><creatorcontrib>NABESHIMA, Kazumi</creatorcontrib><creatorcontrib>YAMAUCHI, Koji</creatorcontrib><creatorcontrib>ABE, Fumiaki</creatorcontrib><creatorcontrib>GOTO, Tsuyoshi</creatorcontrib><creatorcontrib>KAWADA, Teruo</creatorcontrib><title>Investigating Anti-Obesity Effects by Oral Administration of Aloe vera Gel Extract (AVGE): Possible Involvement in Activation of Brown Adipose Tissue (BAT)</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>The aim of this study is to investigate the mechanism of anti-obesity effects of Aloe vera gel extract (AVGE) containing Aloe sterols. Previously, we reported that oral intake of Aloe vera components has an anti-diabetic and anti-obesity effect. This study was designed to assess the role of brown adipose tissue (BAT) in the anti-obesity effect of AVGE. Six-week-old male mice were divided into three groups; STD (standard diet), HFD (60% high fat diet) and AVGE (60% high fat diet with AVGE treatment). During 11 wk of AVGE administration, body weight has been monitored. Tissue samples were obtained to be measured the weight and evaluated the gene expressions. Mice treated with AVGE had suppressed body weight, and liver and fat weight gain. To investigate BAT activation, we measured the expression of mRNA related to BAT thermogenesis. Mice in the AVGE group had higher expression of Ucp1, Adrb3, and Cidea in BAT compared to HFD. Next, to investigate the possibility that AVGE induced hepatic FGF21, which is an important factor for nutrient and energy homeostasis including BAT regulation, in vitro study was conducted. HepG2 cell stimulated by AVGE were highly expressed FGF21. These results suggested that BAT activation partially contributes to mechanism of anti-obesity effect of Aloe sterols in diet-induced obesity (DIO) models. However, further study is needed to determine the predominant mechanism.</description><subject>Adipose Tissue, Brown - drug effects</subject><subject>Adipose Tissue, Brown - metabolism</subject><subject>Administration, Oral</subject><subject>Aloe - chemistry</subject><subject>Aloe sterols</subject><subject>Animals</subject><subject>Anti-Obesity Agents - pharmacology</subject><subject>Anti-Obesity Agents - therapeutic use</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fats - adverse effects</subject><subject>DIO</subject><subject>Energy Metabolism</subject><subject>FGF21</subject><subject>Fibroblast Growth Factors - metabolism</subject><subject>Hep G2 Cells</subject><subject>Humans</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Mice, Inbred C57BL</subject><subject>Obesity - etiology</subject><subject>Obesity - metabolism</subject><subject>Obesity - prevention & control</subject><subject>Phytosterols - pharmacology</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Preparations - chemistry</subject><subject>Plant Preparations - pharmacology</subject><subject>Plant Preparations - therapeutic use</subject><subject>PPAR</subject><subject>Thermogenesis - drug effects</subject><subject>UCP</subject><subject>Weight Gain - drug effects</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFu1DAQhi0EotvCiTuaY6sqixPbccIBKa2WpVKl5bBwjexkvHiVdVa2G9hn4WVxtSWnkf759M_oI-RDTpcsl_LT3oVpWZbLXJavyCKvqjyTkhevyYIymme8ovSCXIawp5TXFa_ekgtWMEFzWS_I3wc3YYh2p6J1O2hctNlGY7DxBCtjsIsB9Ak2Xg3Q9AfrbIg-saOD0UAzjAgTegVrHGD1J626CNfNz_Xq5jN8H0OwekBIN8ZhwgO6CNZB00U7zR13fvydst4ex4CwtSE8IVzfNdubd-SNUUPA9y_zivz4utref8seN-uH--Yx64QQMTMceVXovhIll0yqlNZ1X4paKxS65lqzAlHIgivWJ04oY3pKBZN90WFt2BW5Pfd2Pn3s0bRHbw_Kn9qcts-K22fFbVm2SXGiP57p45M-YD-z_50m4MsZ2IeodjgDykfbDTiXFS-N86L7pXyLjv0DS6WQWw</recordid><startdate>20200430</startdate><enddate>20200430</enddate><creator>TADA, Asuka</creator><creator>MISAWA, Eriko</creator><creator>TANAKA, Miyuki</creator><creator>SAITO, Marie</creator><creator>NABESHIMA, Kazumi</creator><creator>YAMAUCHI, Koji</creator><creator>ABE, Fumiaki</creator><creator>GOTO, Tsuyoshi</creator><creator>KAWADA, Teruo</creator><general>Center for Academic Publications Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20200430</creationdate><title>Investigating Anti-Obesity Effects by Oral Administration of Aloe vera Gel Extract (AVGE): Possible Involvement in Activation of Brown Adipose Tissue (BAT)</title><author>TADA, Asuka ; MISAWA, Eriko ; TANAKA, Miyuki ; SAITO, Marie ; NABESHIMA, Kazumi ; YAMAUCHI, Koji ; ABE, Fumiaki ; GOTO, Tsuyoshi ; KAWADA, Teruo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c555t-f4e482bd8564737ac5599d659bae5b94bb32ee5724a3d2bd5affd00537d2ce9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipose Tissue, Brown - drug effects</topic><topic>Adipose Tissue, Brown - metabolism</topic><topic>Administration, Oral</topic><topic>Aloe - chemistry</topic><topic>Aloe sterols</topic><topic>Animals</topic><topic>Anti-Obesity Agents - pharmacology</topic><topic>Anti-Obesity Agents - therapeutic use</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fats - adverse effects</topic><topic>DIO</topic><topic>Energy Metabolism</topic><topic>FGF21</topic><topic>Fibroblast Growth Factors - metabolism</topic><topic>Hep G2 Cells</topic><topic>Humans</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Mice, Inbred C57BL</topic><topic>Obesity - etiology</topic><topic>Obesity - metabolism</topic><topic>Obesity - prevention & control</topic><topic>Phytosterols - pharmacology</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Preparations - chemistry</topic><topic>Plant Preparations - pharmacology</topic><topic>Plant Preparations - therapeutic use</topic><topic>PPAR</topic><topic>Thermogenesis - drug effects</topic><topic>UCP</topic><topic>Weight Gain - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TADA, Asuka</creatorcontrib><creatorcontrib>MISAWA, Eriko</creatorcontrib><creatorcontrib>TANAKA, Miyuki</creatorcontrib><creatorcontrib>SAITO, Marie</creatorcontrib><creatorcontrib>NABESHIMA, Kazumi</creatorcontrib><creatorcontrib>YAMAUCHI, Koji</creatorcontrib><creatorcontrib>ABE, Fumiaki</creatorcontrib><creatorcontrib>GOTO, Tsuyoshi</creatorcontrib><creatorcontrib>KAWADA, Teruo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TADA, Asuka</au><au>MISAWA, Eriko</au><au>TANAKA, Miyuki</au><au>SAITO, Marie</au><au>NABESHIMA, Kazumi</au><au>YAMAUCHI, Koji</au><au>ABE, Fumiaki</au><au>GOTO, Tsuyoshi</au><au>KAWADA, Teruo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigating Anti-Obesity Effects by Oral Administration of Aloe vera Gel Extract (AVGE): Possible Involvement in Activation of Brown Adipose Tissue (BAT)</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>2020-04-30</date><risdate>2020</risdate><volume>66</volume><issue>2</issue><spage>176</spage><epage>184</epage><pages>176-184</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>The aim of this study is to investigate the mechanism of anti-obesity effects of Aloe vera gel extract (AVGE) containing Aloe sterols. Previously, we reported that oral intake of Aloe vera components has an anti-diabetic and anti-obesity effect. This study was designed to assess the role of brown adipose tissue (BAT) in the anti-obesity effect of AVGE. Six-week-old male mice were divided into three groups; STD (standard diet), HFD (60% high fat diet) and AVGE (60% high fat diet with AVGE treatment). During 11 wk of AVGE administration, body weight has been monitored. Tissue samples were obtained to be measured the weight and evaluated the gene expressions. Mice treated with AVGE had suppressed body weight, and liver and fat weight gain. To investigate BAT activation, we measured the expression of mRNA related to BAT thermogenesis. Mice in the AVGE group had higher expression of Ucp1, Adrb3, and Cidea in BAT compared to HFD. Next, to investigate the possibility that AVGE induced hepatic FGF21, which is an important factor for nutrient and energy homeostasis including BAT regulation, in vitro study was conducted. HepG2 cell stimulated by AVGE were highly expressed FGF21. These results suggested that BAT activation partially contributes to mechanism of anti-obesity effect of Aloe sterols in diet-induced obesity (DIO) models. However, further study is needed to determine the predominant mechanism.</abstract><cop>Japan</cop><pub>Center for Academic Publications Japan</pub><pmid>32350179</pmid><doi>10.3177/jnsv.66.176</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Administration, Oral Aloe - chemistry Aloe sterols Animals Anti-Obesity Agents - pharmacology Anti-Obesity Agents - therapeutic use Diet, High-Fat - adverse effects Dietary Fats - administration & dosage Dietary Fats - adverse effects DIO Energy Metabolism FGF21 Fibroblast Growth Factors - metabolism Hep G2 Cells Humans Liver - drug effects Liver - metabolism Male Mice, Inbred C57BL Obesity - etiology Obesity - metabolism Obesity - prevention & control Phytosterols - pharmacology Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Preparations - chemistry Plant Preparations - pharmacology Plant Preparations - therapeutic use PPAR Thermogenesis - drug effects UCP Weight Gain - drug effects |
| title | Investigating Anti-Obesity Effects by Oral Administration of Aloe vera Gel Extract (AVGE): Possible Involvement in Activation of Brown Adipose Tissue (BAT) |
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