Rubiscolin-6, a δ-Opioid Peptide from Spinach RuBisCO, Exerts Antidepressant-Like Effect in Restraint-Stressed Mice

Rubiscolin-6 (Tyr-Pro-Leu-Asp-Leu-Phe) is produced by a pepsin digest of spinach d -ribulose-1,5-bisphosphate carboxylase/oxygenase (RuBisCO) and known to act as an agonist on δ-opioid receptor. Here, we showed that administration of rubiscolin-6 reduced immobility time in the tail suspension test i...

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Veröffentlicht in:	Journal of Nutritional Science and Vitaminology 2019/04/30, Vol.65(2), pp.202-204
Hauptverfasser:	MITSUMOTO, Yasuhide, SATO, Reina, TAGAWA, Noriko, KATO, Ikuo
Format:	Artikel
Sprache:	eng
Schlagworte:	acute restraint stress Animals Antidepressive Agents - pharmacology Behavior, Animal - drug effects depression Male Mice Mice, Inbred ICR Peptide Fragments - pharmacology Plant Proteins - pharmacology Restraint, Physical - adverse effects Ribulose-Bisphosphate Carboxylase - pharmacology rubiscolin-6 Spinacia oleracea - chemistry Spinacia oleracea - enzymology Stress, Psychological tail suspension test δ-opioid receptor
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