Detection of Fucoidan in Urine after Oral Intake of Traditional Japanese Seaweed, Okinawa mozuku (Cladosiphon okamuranus Tokida)
Seaweed has been considered an indigestible food. Fucoidan, which is found abundantly in seaweed, especially in Cladosiphon okamuranus (Okinawa mozuku), has a high molecular weight and has been long believed to be hardly absorbed in the human digestive system due to a lack of certain digestive enzym...
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| Veröffentlicht in: | Journal of Nutritional Science and Vitaminology 2017, Vol.63(6), pp.419-421 |
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| container_end_page | 421 |
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| container_issue | 6 |
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| container_title | Journal of Nutritional Science and Vitaminology |
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| creator | TOKITA, Yoshiharu HIRAYAMA, Minami NAKAJIMA, Katsuyuki TAMAKI, Kenei IHA, Masahiko NAGAMINE, Takeaki |
| description | Seaweed has been considered an indigestible food. Fucoidan, which is found abundantly in seaweed, especially in Cladosiphon okamuranus (Okinawa mozuku), has a high molecular weight and has been long believed to be hardly absorbed in the human digestive system due to a lack of certain digestive enzymes. We previously reported that fucoidan can be detected in serum and urine after oral intake of purified fucoidan in humans and rats. However, it is unclear whether the fucoidan in mozuku can be absorbed after digestion of mozuku. Therefore, we attempted to detect fucoidan in urine before and after mozuku intake. We determined the fucoidan concentration in urine after oral intake of Okinawa mozuku and urinary fucoidan was detected in several volunteers. In conclusion, these results suggest that fucoidan in mozuku can be absorbed after ingestion of mozuku. |
| doi_str_mv | 10.3177/jnsv.63.419 |
| format | Article |
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Fucoidan, which is found abundantly in seaweed, especially in Cladosiphon okamuranus (Okinawa mozuku), has a high molecular weight and has been long believed to be hardly absorbed in the human digestive system due to a lack of certain digestive enzymes. We previously reported that fucoidan can be detected in serum and urine after oral intake of purified fucoidan in humans and rats. However, it is unclear whether the fucoidan in mozuku can be absorbed after digestion of mozuku. Therefore, we attempted to detect fucoidan in urine before and after mozuku intake. We determined the fucoidan concentration in urine after oral intake of Okinawa mozuku and urinary fucoidan was detected in several volunteers. In conclusion, these results suggest that fucoidan in mozuku can be absorbed after ingestion of mozuku.</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.63.419</identifier><identifier>PMID: 29332904</identifier><language>eng</language><publisher>Japan: Center for Academic Publications Japan</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological Availability ; Cladosiphon okamuranus (Okinawa mozuku) ; Diet ; Digestion ; Female ; fucoidan ; Humans ; Intestinal Absorption ; Male ; Middle Aged ; oral intake ; Phaeophyceae - chemistry ; Polysaccharides - pharmacokinetics ; Polysaccharides - urine ; Seaweed - chemistry ; urine</subject><ispartof>Journal of Nutritional Science and Vitaminology, 2017, Vol.63(6), pp.419-421</ispartof><rights>2017 by the Center for Academic Publications Japan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-481f934290fea55b76cef7feaa1a040714c1fd5459610865d79ab0ef817eb49b3</citedby><cites>FETCH-LOGICAL-c555t-481f934290fea55b76cef7feaa1a040714c1fd5459610865d79ab0ef817eb49b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29332904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TOKITA, Yoshiharu</creatorcontrib><creatorcontrib>HIRAYAMA, Minami</creatorcontrib><creatorcontrib>NAKAJIMA, Katsuyuki</creatorcontrib><creatorcontrib>TAMAKI, Kenei</creatorcontrib><creatorcontrib>IHA, Masahiko</creatorcontrib><creatorcontrib>NAGAMINE, Takeaki</creatorcontrib><title>Detection of Fucoidan in Urine after Oral Intake of Traditional Japanese Seaweed, Okinawa mozuku (Cladosiphon okamuranus Tokida)</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>Seaweed has been considered an indigestible food. Fucoidan, which is found abundantly in seaweed, especially in Cladosiphon okamuranus (Okinawa mozuku), has a high molecular weight and has been long believed to be hardly absorbed in the human digestive system due to a lack of certain digestive enzymes. We previously reported that fucoidan can be detected in serum and urine after oral intake of purified fucoidan in humans and rats. However, it is unclear whether the fucoidan in mozuku can be absorbed after digestion of mozuku. Therefore, we attempted to detect fucoidan in urine before and after mozuku intake. We determined the fucoidan concentration in urine after oral intake of Okinawa mozuku and urinary fucoidan was detected in several volunteers. In conclusion, these results suggest that fucoidan in mozuku can be absorbed after ingestion of mozuku.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological Availability</subject><subject>Cladosiphon okamuranus (Okinawa mozuku)</subject><subject>Diet</subject><subject>Digestion</subject><subject>Female</subject><subject>fucoidan</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>Male</subject><subject>Middle Aged</subject><subject>oral intake</subject><subject>Phaeophyceae - chemistry</subject><subject>Polysaccharides - pharmacokinetics</subject><subject>Polysaccharides - urine</subject><subject>Seaweed - chemistry</subject><subject>urine</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFPwzAMhSMEgjE4cUc5gmAjWdKmvSChwWBo0g5s58ptHZZ1S6ekZYITP51WGzvZsj8_24-QK876giv1sLT-qx-KvuTxEenwKOI9peTgmHSYYLwnI8bOyLn3S8ZkHMnolJwNYiEGMZMd8vuMFWaVKS0tNR3VWWlysNRYOnfGIgVdoaNTBys6thUU2GIzB7lpZ5rqO2zAokf6gbBFzO_ptDAWtkDX5U9d1PRmuIK89GazaHcUsK4d2NrTWVk0q24vyImGlcfLfeyS-ehlNnzrTaav4-HTpJcFQVA1X3AdC9kcrRGCIFVhhlo1OXBgkikuM67zQAZxyFkUBrmKIWWoI64wlXEquuRup5u50nuHOtk4swb3nXCWtD4mrY9JKJLGx4a-3tGbOl1jfmD_jWuAxx2w9BV84gEAV5lshQexcK94aGQLcAla8QfIcodE</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>TOKITA, Yoshiharu</creator><creator>HIRAYAMA, Minami</creator><creator>NAKAJIMA, Katsuyuki</creator><creator>TAMAKI, Kenei</creator><creator>IHA, Masahiko</creator><creator>NAGAMINE, Takeaki</creator><general>Center for Academic Publications Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2017</creationdate><title>Detection of Fucoidan in Urine after Oral Intake of Traditional Japanese Seaweed, Okinawa mozuku (Cladosiphon okamuranus Tokida)</title><author>TOKITA, Yoshiharu ; HIRAYAMA, Minami ; NAKAJIMA, Katsuyuki ; TAMAKI, Kenei ; IHA, Masahiko ; NAGAMINE, Takeaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c555t-481f934290fea55b76cef7feaa1a040714c1fd5459610865d79ab0ef817eb49b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological Availability</topic><topic>Cladosiphon okamuranus (Okinawa mozuku)</topic><topic>Diet</topic><topic>Digestion</topic><topic>Female</topic><topic>fucoidan</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>Male</topic><topic>Middle Aged</topic><topic>oral intake</topic><topic>Phaeophyceae - chemistry</topic><topic>Polysaccharides - pharmacokinetics</topic><topic>Polysaccharides - urine</topic><topic>Seaweed - chemistry</topic><topic>urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TOKITA, Yoshiharu</creatorcontrib><creatorcontrib>HIRAYAMA, Minami</creatorcontrib><creatorcontrib>NAKAJIMA, Katsuyuki</creatorcontrib><creatorcontrib>TAMAKI, Kenei</creatorcontrib><creatorcontrib>IHA, Masahiko</creatorcontrib><creatorcontrib>NAGAMINE, Takeaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TOKITA, Yoshiharu</au><au>HIRAYAMA, Minami</au><au>NAKAJIMA, Katsuyuki</au><au>TAMAKI, Kenei</au><au>IHA, Masahiko</au><au>NAGAMINE, Takeaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of Fucoidan in Urine after Oral Intake of Traditional Japanese Seaweed, Okinawa mozuku (Cladosiphon okamuranus Tokida)</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>2017</date><risdate>2017</risdate><volume>63</volume><issue>6</issue><spage>419</spage><epage>421</epage><pages>419-421</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>Seaweed has been considered an indigestible food. Fucoidan, which is found abundantly in seaweed, especially in Cladosiphon okamuranus (Okinawa mozuku), has a high molecular weight and has been long believed to be hardly absorbed in the human digestive system due to a lack of certain digestive enzymes. We previously reported that fucoidan can be detected in serum and urine after oral intake of purified fucoidan in humans and rats. However, it is unclear whether the fucoidan in mozuku can be absorbed after digestion of mozuku. Therefore, we attempted to detect fucoidan in urine before and after mozuku intake. We determined the fucoidan concentration in urine after oral intake of Okinawa mozuku and urinary fucoidan was detected in several volunteers. In conclusion, these results suggest that fucoidan in mozuku can be absorbed after ingestion of mozuku.</abstract><cop>Japan</cop><pub>Center for Academic Publications Japan</pub><pmid>29332904</pmid><doi>10.3177/jnsv.63.419</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Nutritional Science and Vitaminology, 2017, Vol.63(6), pp.419-421 |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Aged, 80 and over Biological Availability Cladosiphon okamuranus (Okinawa mozuku) Diet Digestion Female fucoidan Humans Intestinal Absorption Male Middle Aged oral intake Phaeophyceae - chemistry Polysaccharides - pharmacokinetics Polysaccharides - urine Seaweed - chemistry urine |
| title | Detection of Fucoidan in Urine after Oral Intake of Traditional Japanese Seaweed, Okinawa mozuku (Cladosiphon okamuranus Tokida) |
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