Resistant Maltodextrin Decreases Micellar Solubility of Lipids and Diffusion of Bile Salt Micelles and Suppresses Incorporation of Micellar Fatty Acids into Caco-2 Cells
Several studies have suggested that resistant maltodextrin (RMD) suppresses intestinal lipid absorption in experimental animals and humans. However, possible mechanisms underlying this effect are not known. In this study, effects of RMD on processes of the absorption of various lipids were investiga...
Gespeichert in:
| Veröffentlicht in: | Journal of Nutritional Science and Vitaminology 2016, Vol.62(5), pp.335-340 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 340 |
|---|---|
| container_issue | 5 |
| container_start_page | 335 |
| container_title | Journal of Nutritional Science and Vitaminology |
| container_volume | 62 |
| creator | IKEDA, Ikuo TAMAKUNI, Kyouhei SAKUMA, Tomomi OZAWA, Ran INOUE, Nao KISHIMOTO, Yuka |
| description | Several studies have suggested that resistant maltodextrin (RMD) suppresses intestinal lipid absorption in experimental animals and humans. However, possible mechanisms underlying this effect are not known. In this study, effects of RMD on processes of the absorption of various lipids were investigated in vitro. RMD dose-dependently suppressed the solubility of various lipid components, including 1-mono-oleoylglycerol, oleic acid, and phosphatidylcholine in bile salt micelles in vitro. When the diffusion rate of bile salt micelles through a filter membrane was investigated in vitro, bile salt micelles containing RMD diffused more slowly than those without RMD. Incorporation of [1-14C] oleic acid into Caco-2 cells from the RMD-containing bile salt micelles was significantly smaller than that from the control micelles (without RMD). These results show that RMD suppresses intestinal absorption of lipids by decreasing their micellar solubility and the diffusion rate of bile salt micelles. |
| doi_str_mv | 10.3177/jnsv.62.335 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_3177_jnsv_62_335</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>27928121</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-bcb65016754ee5dd1b23bab6bc19b447504c0dd1b88ececea7cf920ed5e1b3013</originalsourceid><addsrcrecordid>eNo9kF1LwzAUQIMobn48-S55l84kTdvsRdDpVJgITp9Lkt5qRteUJBP3k_yXpmyWPARyzz2Bg9AFJZOUFsX1qvXfk5xN0jQ7QGMqBE2KgrNDNCYpoQkXhIzQifcrQvhUcHGMRqyYMkEZHaPfN_DGB9kG_CKbYCv4Cc60-B60A-nB4xejoWmkw0vbbJRpTNhiW-OF6UzlsWwrfG_qeuONbfv3O9MAXkbVfhF2zHLTdQ58L3xutXWddTLsV4Yf5jJE-a3uxaYNFs-ktgnDszj2Z-iolo2H8_19ij7mD--zp2Tx-vg8u10kmqciJEqrPCM0LzIOkFUVVSxVUuVK06nivMgI16R_FgJ0PLLQ9ZQRqDKgKvZKT9HVzqud9d5BXXbOrKXblpSUffCyD17mrIzBI325o7uNWkM1sP-FI3CzA1ax8icMgHTB6AYGWbY3DgP9JV0JbfoHrO2XcA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Resistant Maltodextrin Decreases Micellar Solubility of Lipids and Diffusion of Bile Salt Micelles and Suppresses Incorporation of Micellar Fatty Acids into Caco-2 Cells</title><source>J-STAGE Free</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>IKEDA, Ikuo ; TAMAKUNI, Kyouhei ; SAKUMA, Tomomi ; OZAWA, Ran ; INOUE, Nao ; KISHIMOTO, Yuka</creator><creatorcontrib>IKEDA, Ikuo ; TAMAKUNI, Kyouhei ; SAKUMA, Tomomi ; OZAWA, Ran ; INOUE, Nao ; KISHIMOTO, Yuka</creatorcontrib><description>Several studies have suggested that resistant maltodextrin (RMD) suppresses intestinal lipid absorption in experimental animals and humans. However, possible mechanisms underlying this effect are not known. In this study, effects of RMD on processes of the absorption of various lipids were investigated in vitro. RMD dose-dependently suppressed the solubility of various lipid components, including 1-mono-oleoylglycerol, oleic acid, and phosphatidylcholine in bile salt micelles in vitro. When the diffusion rate of bile salt micelles through a filter membrane was investigated in vitro, bile salt micelles containing RMD diffused more slowly than those without RMD. Incorporation of [1-14C] oleic acid into Caco-2 cells from the RMD-containing bile salt micelles was significantly smaller than that from the control micelles (without RMD). These results show that RMD suppresses intestinal absorption of lipids by decreasing their micellar solubility and the diffusion rate of bile salt micelles.</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.62.335</identifier><identifier>PMID: 27928121</identifier><language>eng</language><publisher>Japan: Center for Academic Publications Japan</publisher><subject>Bile Acids and Salts - chemistry ; bile salt micelles ; Caco-2 Cells ; Cell Differentiation ; Fatty Acids - chemistry ; Glycerides - chemistry ; Humans ; Intestinal Absorption ; lipid absorption ; Micelles ; Oleic Acid - chemistry ; Phosphatidylcholines - chemistry ; Polysaccharides - chemistry ; resistant maltodextrin ; Solubility ; Triglycerides - chemistry</subject><ispartof>Journal of Nutritional Science and Vitaminology, 2016, Vol.62(5), pp.335-340</ispartof><rights>2016 by the Center for Academic Publications Japan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-bcb65016754ee5dd1b23bab6bc19b447504c0dd1b88ececea7cf920ed5e1b3013</citedby><cites>FETCH-LOGICAL-c438t-bcb65016754ee5dd1b23bab6bc19b447504c0dd1b88ececea7cf920ed5e1b3013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27928121$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IKEDA, Ikuo</creatorcontrib><creatorcontrib>TAMAKUNI, Kyouhei</creatorcontrib><creatorcontrib>SAKUMA, Tomomi</creatorcontrib><creatorcontrib>OZAWA, Ran</creatorcontrib><creatorcontrib>INOUE, Nao</creatorcontrib><creatorcontrib>KISHIMOTO, Yuka</creatorcontrib><title>Resistant Maltodextrin Decreases Micellar Solubility of Lipids and Diffusion of Bile Salt Micelles and Suppresses Incorporation of Micellar Fatty Acids into Caco-2 Cells</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>Several studies have suggested that resistant maltodextrin (RMD) suppresses intestinal lipid absorption in experimental animals and humans. However, possible mechanisms underlying this effect are not known. In this study, effects of RMD on processes of the absorption of various lipids were investigated in vitro. RMD dose-dependently suppressed the solubility of various lipid components, including 1-mono-oleoylglycerol, oleic acid, and phosphatidylcholine in bile salt micelles in vitro. When the diffusion rate of bile salt micelles through a filter membrane was investigated in vitro, bile salt micelles containing RMD diffused more slowly than those without RMD. Incorporation of [1-14C] oleic acid into Caco-2 cells from the RMD-containing bile salt micelles was significantly smaller than that from the control micelles (without RMD). These results show that RMD suppresses intestinal absorption of lipids by decreasing their micellar solubility and the diffusion rate of bile salt micelles.</description><subject>Bile Acids and Salts - chemistry</subject><subject>bile salt micelles</subject><subject>Caco-2 Cells</subject><subject>Cell Differentiation</subject><subject>Fatty Acids - chemistry</subject><subject>Glycerides - chemistry</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>lipid absorption</subject><subject>Micelles</subject><subject>Oleic Acid - chemistry</subject><subject>Phosphatidylcholines - chemistry</subject><subject>Polysaccharides - chemistry</subject><subject>resistant maltodextrin</subject><subject>Solubility</subject><subject>Triglycerides - chemistry</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF1LwzAUQIMobn48-S55l84kTdvsRdDpVJgITp9Lkt5qRteUJBP3k_yXpmyWPARyzz2Bg9AFJZOUFsX1qvXfk5xN0jQ7QGMqBE2KgrNDNCYpoQkXhIzQifcrQvhUcHGMRqyYMkEZHaPfN_DGB9kG_CKbYCv4Cc60-B60A-nB4xejoWmkw0vbbJRpTNhiW-OF6UzlsWwrfG_qeuONbfv3O9MAXkbVfhF2zHLTdQ58L3xutXWddTLsV4Yf5jJE-a3uxaYNFs-ktgnDszj2Z-iolo2H8_19ij7mD--zp2Tx-vg8u10kmqciJEqrPCM0LzIOkFUVVSxVUuVK06nivMgI16R_FgJ0PLLQ9ZQRqDKgKvZKT9HVzqud9d5BXXbOrKXblpSUffCyD17mrIzBI325o7uNWkM1sP-FI3CzA1ax8icMgHTB6AYGWbY3DgP9JV0JbfoHrO2XcA</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>IKEDA, Ikuo</creator><creator>TAMAKUNI, Kyouhei</creator><creator>SAKUMA, Tomomi</creator><creator>OZAWA, Ran</creator><creator>INOUE, Nao</creator><creator>KISHIMOTO, Yuka</creator><general>Center for Academic Publications Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2016</creationdate><title>Resistant Maltodextrin Decreases Micellar Solubility of Lipids and Diffusion of Bile Salt Micelles and Suppresses Incorporation of Micellar Fatty Acids into Caco-2 Cells</title><author>IKEDA, Ikuo ; TAMAKUNI, Kyouhei ; SAKUMA, Tomomi ; OZAWA, Ran ; INOUE, Nao ; KISHIMOTO, Yuka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-bcb65016754ee5dd1b23bab6bc19b447504c0dd1b88ececea7cf920ed5e1b3013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Bile Acids and Salts - chemistry</topic><topic>bile salt micelles</topic><topic>Caco-2 Cells</topic><topic>Cell Differentiation</topic><topic>Fatty Acids - chemistry</topic><topic>Glycerides - chemistry</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>lipid absorption</topic><topic>Micelles</topic><topic>Oleic Acid - chemistry</topic><topic>Phosphatidylcholines - chemistry</topic><topic>Polysaccharides - chemistry</topic><topic>resistant maltodextrin</topic><topic>Solubility</topic><topic>Triglycerides - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>IKEDA, Ikuo</creatorcontrib><creatorcontrib>TAMAKUNI, Kyouhei</creatorcontrib><creatorcontrib>SAKUMA, Tomomi</creatorcontrib><creatorcontrib>OZAWA, Ran</creatorcontrib><creatorcontrib>INOUE, Nao</creatorcontrib><creatorcontrib>KISHIMOTO, Yuka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>IKEDA, Ikuo</au><au>TAMAKUNI, Kyouhei</au><au>SAKUMA, Tomomi</au><au>OZAWA, Ran</au><au>INOUE, Nao</au><au>KISHIMOTO, Yuka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistant Maltodextrin Decreases Micellar Solubility of Lipids and Diffusion of Bile Salt Micelles and Suppresses Incorporation of Micellar Fatty Acids into Caco-2 Cells</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>2016</date><risdate>2016</risdate><volume>62</volume><issue>5</issue><spage>335</spage><epage>340</epage><pages>335-340</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>Several studies have suggested that resistant maltodextrin (RMD) suppresses intestinal lipid absorption in experimental animals and humans. However, possible mechanisms underlying this effect are not known. In this study, effects of RMD on processes of the absorption of various lipids were investigated in vitro. RMD dose-dependently suppressed the solubility of various lipid components, including 1-mono-oleoylglycerol, oleic acid, and phosphatidylcholine in bile salt micelles in vitro. When the diffusion rate of bile salt micelles through a filter membrane was investigated in vitro, bile salt micelles containing RMD diffused more slowly than those without RMD. Incorporation of [1-14C] oleic acid into Caco-2 cells from the RMD-containing bile salt micelles was significantly smaller than that from the control micelles (without RMD). These results show that RMD suppresses intestinal absorption of lipids by decreasing their micellar solubility and the diffusion rate of bile salt micelles.</abstract><cop>Japan</cop><pub>Center for Academic Publications Japan</pub><pmid>27928121</pmid><doi>10.3177/jnsv.62.335</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-4800 |
| ispartof | Journal of Nutritional Science and Vitaminology, 2016, Vol.62(5), pp.335-340 |
| issn | 0301-4800 1881-7742 |
| language | eng |
| recordid | cdi_crossref_primary_10_3177_jnsv_62_335 |
| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Bile Acids and Salts - chemistry bile salt micelles Caco-2 Cells Cell Differentiation Fatty Acids - chemistry Glycerides - chemistry Humans Intestinal Absorption lipid absorption Micelles Oleic Acid - chemistry Phosphatidylcholines - chemistry Polysaccharides - chemistry resistant maltodextrin Solubility Triglycerides - chemistry |
| title | Resistant Maltodextrin Decreases Micellar Solubility of Lipids and Diffusion of Bile Salt Micelles and Suppresses Incorporation of Micellar Fatty Acids into Caco-2 Cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T12%3A12%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Resistant%20Maltodextrin%20Decreases%20Micellar%20Solubility%20of%20Lipids%20and%20Diffusion%20of%20Bile%20Salt%20Micelles%20and%20Suppresses%20Incorporation%20of%20Micellar%20Fatty%20Acids%20into%20Caco-2%20Cells&rft.jtitle=Journal%20of%20Nutritional%20Science%20and%20Vitaminology&rft.au=IKEDA,%20Ikuo&rft.date=2016&rft.volume=62&rft.issue=5&rft.spage=335&rft.epage=340&rft.pages=335-340&rft.issn=0301-4800&rft.eissn=1881-7742&rft_id=info:doi/10.3177/jnsv.62.335&rft_dat=%3Cpubmed_cross%3E27928121%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/27928121&rfr_iscdi=true |