Deoxycholic Acid Is Involved in the Proliferation and Migration of Vascular Smooth Muscle Cells

Obesity is increasingly becoming associated with increased risk of atherosclerosis. Serum levels of the bile acid deoxycholic acid (DCA) are elevated in mice with obesity induced by a high-fat (HF) diet. Therefore, we investigated the influence of DCA on the functions of vascular smooth muscle cells...

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Veröffentlicht in:	Journal of Nutritional Science and Vitaminology 2014, Vol.60(6), pp.450-454
Hauptverfasser:	SHIMIZU, Hidehisa, HAGIO, Masahito, IWAYA, Hitoshi, TSUNEKI, Ikuya, LEE, Ja-Young, FUKIYA, Satoru, YOKOTA, Atsushi, MIYAZAKI, Hitoshi, HARA, Hiroshi, ISHIZUKA, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals atherosclerosis Atherosclerosis - etiology Atherosclerosis - pathology bile acid Binding Sites Cell Movement - drug effects Cell Proliferation - drug effects Cells, Cultured Deoxycholic Acid - adverse effects enterobacterium high-fat diet JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Promoter Regions, Genetic Rats Rats, Sprague-Dawley Receptor, Platelet-Derived Growth Factor beta - genetics Receptor, Platelet-Derived Growth Factor beta - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Up-Regulation
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