Oral administration of acidic xylooligosaccharides prevents the development of atopic dermatitis-like skin lesions in NC/Nga mice
We examined whether two types of xylooligosaccharides (neutral or acidic xylooligosaccharides) derived from hardwood kraft pulp ameliorate the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of picryl chloride (PiCl) in NC/Nga mice. Oral administration of acid...
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| creator | Ohbuchi, T., Oji Paper Co. Ltd., Tokyo (Japan) Sakaino, M Takahashi, T Azumi, N Ishikawa, K Kawazoe, S Kobayashi, Y Kido, Y |
| description | We examined whether two types of xylooligosaccharides (neutral or acidic xylooligosaccharides) derived from hardwood kraft pulp ameliorate the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of picryl chloride (PiCl) in NC/Nga mice. Oral administration of acidic xylooligosaccharides at a daily dose of 100 mg/kg significantly prevented the development of AD-like skin lesions. Serum histamine level was significantly suppressed, but serum total IgE level was not significantly suppressed. Moreover, the secretion of inflammatory cytokine IL-12 from splenic lymphocytes was significantly suppressed. On the other hand, neutral xylooligosaccharides showed no significant preventive effect on the development of AD-like symptoms. These results suggest that oral administration of acidic xylooligosaccharides may be effective in preventing the development of AD-like skin disease and one of the mechanisms is the suppressive effect on IL-12. |
| doi_str_mv | 10.3177/jnsv.56.54 |
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Ltd., Tokyo (Japan) ; Sakaino, M ; Takahashi, T ; Azumi, N ; Ishikawa, K ; Kawazoe, S ; Kobayashi, Y ; Kido, Y</creator><creatorcontrib>Ohbuchi, T., Oji Paper Co. Ltd., Tokyo (Japan) ; Sakaino, M ; Takahashi, T ; Azumi, N ; Ishikawa, K ; Kawazoe, S ; Kobayashi, Y ; Kido, Y</creatorcontrib><description>We examined whether two types of xylooligosaccharides (neutral or acidic xylooligosaccharides) derived from hardwood kraft pulp ameliorate the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of picryl chloride (PiCl) in NC/Nga mice. Oral administration of acidic xylooligosaccharides at a daily dose of 100 mg/kg significantly prevented the development of AD-like skin lesions. Serum histamine level was significantly suppressed, but serum total IgE level was not significantly suppressed. Moreover, the secretion of inflammatory cytokine IL-12 from splenic lymphocytes was significantly suppressed. On the other hand, neutral xylooligosaccharides showed no significant preventive effect on the development of AD-like symptoms. These results suggest that oral administration of acidic xylooligosaccharides may be effective in preventing the development of AD-like skin disease and one of the mechanisms is the suppressive effect on IL-12.</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.56.54</identifier><identifier>PMID: 20354347</identifier><language>eng</language><publisher>Tokyo: Center for Academic Publications Japan</publisher><subject>acidic xylooligosaccharides ; Acids ; ADMINISTRACION ORAL ; ADMINISTRATION ORALE ; Administration, Oral ; Animals ; APPLICATION METHODS ; atopic dermatitis ; Biological and medical sciences ; CARBOHIDRATOS ; CARBOHYDRATES ; Cells, Cultured ; DERMATITE ; DERMATITIS ; Dermatitis, Atopic - immunology ; Dermatitis, Atopic - pathology ; Dermatitis, Atopic - prevention & control ; ENFERMEDADES DE LA PIEL ; FACTEUR IMMUNOLOGIQUE ; FACTORES INMUNOLOGICOS ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; GLUCIDE ; Histamine - blood ; http://www.fao.org/aos/agrovoc#c_10341 ; http://www.fao.org/aos/agrovoc#c_1300 ; http://www.fao.org/aos/agrovoc#c_27584 ; http://www.fao.org/aos/agrovoc#c_29621 ; http://www.fao.org/aos/agrovoc#c_34031 ; http://www.fao.org/aos/agrovoc#c_36803 ; http://www.fao.org/aos/agrovoc#c_4795 ; http://www.fao.org/aos/agrovoc#c_542 ; http://www.fao.org/aos/agrovoc#c_6259 ; http://www.fao.org/aos/agrovoc#c_7098 ; Immunoglobulin E - blood ; IMMUNOLOGICAL FACTORS ; interleukin-12 ; Interleukin-12 - metabolism ; INTERLEUKINE ; INTERLEUKINS ; INTERLEUQUINAS ; Lymphocytes - drug effects ; Magnoliopsida ; MALADIE DE LA PEAU ; Male ; METHODE D'APPLICATION ; METODOS DE APLICACION ; MICE ; Mice, Inbred Strains ; NC/Nga mouse ; OLIGOSACARIDOS ; OLIGOSACCHARIDE ; OLIGOSACCHARIDES ; Oligosaccharides - administration & dosage ; Oligosaccharides - pharmacology ; Oligosaccharides - therapeutic use ; ORAL ADMINISTRATION ; Phytotherapy ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; prebiotics ; PROTEINAS ; PROTEINE ; PROTEINS ; RATON ; Skin - drug effects ; Skin - immunology ; Skin - pathology ; SKIN DISEASES ; SOURIS ; Spleen - cytology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Wood</subject><ispartof>Journal of Nutritional Science and Vitaminology, 2010, Vol.56(1), pp.54-59</ispartof><rights>2010 by the Center for Academic Publications Japan</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-87a215e6123d25a5b4fdda7a0149a6cda7237c829667285c1a67aa8659460dc03</citedby><cites>FETCH-LOGICAL-c571t-87a215e6123d25a5b4fdda7a0149a6cda7237c829667285c1a67aa8659460dc03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22734440$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20354347$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohbuchi, T., Oji Paper Co. Ltd., Tokyo (Japan)</creatorcontrib><creatorcontrib>Sakaino, M</creatorcontrib><creatorcontrib>Takahashi, T</creatorcontrib><creatorcontrib>Azumi, N</creatorcontrib><creatorcontrib>Ishikawa, K</creatorcontrib><creatorcontrib>Kawazoe, S</creatorcontrib><creatorcontrib>Kobayashi, Y</creatorcontrib><creatorcontrib>Kido, Y</creatorcontrib><title>Oral administration of acidic xylooligosaccharides prevents the development of atopic dermatitis-like skin lesions in NC/Nga mice</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>We examined whether two types of xylooligosaccharides (neutral or acidic xylooligosaccharides) derived from hardwood kraft pulp ameliorate the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of picryl chloride (PiCl) in NC/Nga mice. Oral administration of acidic xylooligosaccharides at a daily dose of 100 mg/kg significantly prevented the development of AD-like skin lesions. Serum histamine level was significantly suppressed, but serum total IgE level was not significantly suppressed. Moreover, the secretion of inflammatory cytokine IL-12 from splenic lymphocytes was significantly suppressed. On the other hand, neutral xylooligosaccharides showed no significant preventive effect on the development of AD-like symptoms. These results suggest that oral administration of acidic xylooligosaccharides may be effective in preventing the development of AD-like skin disease and one of the mechanisms is the suppressive effect on IL-12.</description><subject>acidic xylooligosaccharides</subject><subject>Acids</subject><subject>ADMINISTRACION ORAL</subject><subject>ADMINISTRATION ORALE</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>APPLICATION METHODS</subject><subject>atopic dermatitis</subject><subject>Biological and medical sciences</subject><subject>CARBOHIDRATOS</subject><subject>CARBOHYDRATES</subject><subject>Cells, Cultured</subject><subject>DERMATITE</subject><subject>DERMATITIS</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Dermatitis, Atopic - pathology</subject><subject>Dermatitis, Atopic - prevention & control</subject><subject>ENFERMEDADES DE LA PIEL</subject><subject>FACTEUR IMMUNOLOGIQUE</subject><subject>FACTORES INMUNOLOGICOS</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GLUCIDE</subject><subject>Histamine - blood</subject><subject>http://www.fao.org/aos/agrovoc#c_10341</subject><subject>http://www.fao.org/aos/agrovoc#c_1300</subject><subject>http://www.fao.org/aos/agrovoc#c_27584</subject><subject>http://www.fao.org/aos/agrovoc#c_29621</subject><subject>http://www.fao.org/aos/agrovoc#c_34031</subject><subject>http://www.fao.org/aos/agrovoc#c_36803</subject><subject>http://www.fao.org/aos/agrovoc#c_4795</subject><subject>http://www.fao.org/aos/agrovoc#c_542</subject><subject>http://www.fao.org/aos/agrovoc#c_6259</subject><subject>http://www.fao.org/aos/agrovoc#c_7098</subject><subject>Immunoglobulin E - blood</subject><subject>IMMUNOLOGICAL FACTORS</subject><subject>interleukin-12</subject><subject>Interleukin-12 - metabolism</subject><subject>INTERLEUKINE</subject><subject>INTERLEUKINS</subject><subject>INTERLEUQUINAS</subject><subject>Lymphocytes - drug effects</subject><subject>Magnoliopsida</subject><subject>MALADIE DE LA PEAU</subject><subject>Male</subject><subject>METHODE D'APPLICATION</subject><subject>METODOS DE APLICACION</subject><subject>MICE</subject><subject>Mice, Inbred Strains</subject><subject>NC/Nga mouse</subject><subject>OLIGOSACARIDOS</subject><subject>OLIGOSACCHARIDE</subject><subject>OLIGOSACCHARIDES</subject><subject>Oligosaccharides - administration & dosage</subject><subject>Oligosaccharides - pharmacology</subject><subject>Oligosaccharides - therapeutic use</subject><subject>ORAL ADMINISTRATION</subject><subject>Phytotherapy</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>prebiotics</subject><subject>PROTEINAS</subject><subject>PROTEINE</subject><subject>PROTEINS</subject><subject>RATON</subject><subject>Skin - drug effects</subject><subject>Skin - immunology</subject><subject>Skin - pathology</subject><subject>SKIN DISEASES</subject><subject>SOURIS</subject><subject>Spleen - cytology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Wood</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtvEzEUhS0Eomlgwx7kDZtKk_ptZ4VQxFNVywLWo1vbkzr1jEe2qeiSf45DQtjce2R_9xzpIPSKkhWnWl_upvKwkmolxRO0oMbQTmvBnqIF4YR2whByhs5L2REi1kaY5-iMES4FF3qBft9kiBjcGKZQaoYa0oTTgMEGFyz-9RhTimGbClh7Bzk4X_Cc_YOfasH1zmPXdEzz2B7-3tU0tzvn89i8aihdDPcel_sw4ehLcy-4yevN5fUW8Bisf4GeDRCLf3ncS_Tj44fvm8_d1c2nL5v3V52VmtbOaGBUekUZd0yCvBWDc6CBULEGZZtkXFvD1kppZqSloDSAUXItFHGW8CW6OPjanErJfujnHEbIjz0l_b7Hft9jL1XfqlmiNwd4_nk7endC_xXXgLdHAIqFOGSYbCj_Oaa5EGKf-u7A7UqFrT8BkGuw0Z8y6XGI08--7t5PzeH1wWGA1MM2t5Sv3xihhBDGGOd_AAxFna0</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Ohbuchi, T., Oji Paper Co. 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Ltd., Tokyo (Japan) ; Sakaino, M ; Takahashi, T ; Azumi, N ; Ishikawa, K ; Kawazoe, S ; Kobayashi, Y ; Kido, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-87a215e6123d25a5b4fdda7a0149a6cda7237c829667285c1a67aa8659460dc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>acidic xylooligosaccharides</topic><topic>Acids</topic><topic>ADMINISTRACION ORAL</topic><topic>ADMINISTRATION ORALE</topic><topic>Administration, Oral</topic><topic>Animals</topic><topic>APPLICATION METHODS</topic><topic>atopic dermatitis</topic><topic>Biological and medical sciences</topic><topic>CARBOHIDRATOS</topic><topic>CARBOHYDRATES</topic><topic>Cells, Cultured</topic><topic>DERMATITE</topic><topic>DERMATITIS</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Dermatitis, Atopic - pathology</topic><topic>Dermatitis, Atopic - prevention & control</topic><topic>ENFERMEDADES DE LA PIEL</topic><topic>FACTEUR IMMUNOLOGIQUE</topic><topic>FACTORES INMUNOLOGICOS</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GLUCIDE</topic><topic>Histamine - blood</topic><topic>http://www.fao.org/aos/agrovoc#c_10341</topic><topic>http://www.fao.org/aos/agrovoc#c_1300</topic><topic>http://www.fao.org/aos/agrovoc#c_27584</topic><topic>http://www.fao.org/aos/agrovoc#c_29621</topic><topic>http://www.fao.org/aos/agrovoc#c_34031</topic><topic>http://www.fao.org/aos/agrovoc#c_36803</topic><topic>http://www.fao.org/aos/agrovoc#c_4795</topic><topic>http://www.fao.org/aos/agrovoc#c_542</topic><topic>http://www.fao.org/aos/agrovoc#c_6259</topic><topic>http://www.fao.org/aos/agrovoc#c_7098</topic><topic>Immunoglobulin E - blood</topic><topic>IMMUNOLOGICAL FACTORS</topic><topic>interleukin-12</topic><topic>Interleukin-12 - metabolism</topic><topic>INTERLEUKINE</topic><topic>INTERLEUKINS</topic><topic>INTERLEUQUINAS</topic><topic>Lymphocytes - drug effects</topic><topic>Magnoliopsida</topic><topic>MALADIE DE LA PEAU</topic><topic>Male</topic><topic>METHODE D'APPLICATION</topic><topic>METODOS DE APLICACION</topic><topic>MICE</topic><topic>Mice, Inbred Strains</topic><topic>NC/Nga mouse</topic><topic>OLIGOSACARIDOS</topic><topic>OLIGOSACCHARIDE</topic><topic>OLIGOSACCHARIDES</topic><topic>Oligosaccharides - administration & dosage</topic><topic>Oligosaccharides - pharmacology</topic><topic>Oligosaccharides - therapeutic use</topic><topic>ORAL ADMINISTRATION</topic><topic>Phytotherapy</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>prebiotics</topic><topic>PROTEINAS</topic><topic>PROTEINE</topic><topic>PROTEINS</topic><topic>RATON</topic><topic>Skin - drug effects</topic><topic>Skin - immunology</topic><topic>Skin - pathology</topic><topic>SKIN DISEASES</topic><topic>SOURIS</topic><topic>Spleen - cytology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Wood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohbuchi, T., Oji Paper Co. Ltd., Tokyo (Japan)</creatorcontrib><creatorcontrib>Sakaino, M</creatorcontrib><creatorcontrib>Takahashi, T</creatorcontrib><creatorcontrib>Azumi, N</creatorcontrib><creatorcontrib>Ishikawa, K</creatorcontrib><creatorcontrib>Kawazoe, S</creatorcontrib><creatorcontrib>Kobayashi, Y</creatorcontrib><creatorcontrib>Kido, Y</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohbuchi, T., Oji Paper Co. Ltd., Tokyo (Japan)</au><au>Sakaino, M</au><au>Takahashi, T</au><au>Azumi, N</au><au>Ishikawa, K</au><au>Kawazoe, S</au><au>Kobayashi, Y</au><au>Kido, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral administration of acidic xylooligosaccharides prevents the development of atopic dermatitis-like skin lesions in NC/Nga mice</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>2010</date><risdate>2010</risdate><volume>56</volume><issue>1</issue><spage>54</spage><epage>59</epage><pages>54-59</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>We examined whether two types of xylooligosaccharides (neutral or acidic xylooligosaccharides) derived from hardwood kraft pulp ameliorate the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of picryl chloride (PiCl) in NC/Nga mice. Oral administration of acidic xylooligosaccharides at a daily dose of 100 mg/kg significantly prevented the development of AD-like skin lesions. Serum histamine level was significantly suppressed, but serum total IgE level was not significantly suppressed. Moreover, the secretion of inflammatory cytokine IL-12 from splenic lymphocytes was significantly suppressed. On the other hand, neutral xylooligosaccharides showed no significant preventive effect on the development of AD-like symptoms. These results suggest that oral administration of acidic xylooligosaccharides may be effective in preventing the development of AD-like skin disease and one of the mechanisms is the suppressive effect on IL-12.</abstract><cop>Tokyo</cop><pub>Center for Academic Publications Japan</pub><pmid>20354347</pmid><doi>10.3177/jnsv.56.54</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | acidic xylooligosaccharides Acids ADMINISTRACION ORAL ADMINISTRATION ORALE Administration, Oral Animals APPLICATION METHODS atopic dermatitis Biological and medical sciences CARBOHIDRATOS CARBOHYDRATES Cells, Cultured DERMATITE DERMATITIS Dermatitis, Atopic - immunology Dermatitis, Atopic - pathology Dermatitis, Atopic - prevention & control ENFERMEDADES DE LA PIEL FACTEUR IMMUNOLOGIQUE FACTORES INMUNOLOGICOS Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology GLUCIDE Histamine - blood http://www.fao.org/aos/agrovoc#c_10341 http://www.fao.org/aos/agrovoc#c_1300 http://www.fao.org/aos/agrovoc#c_27584 http://www.fao.org/aos/agrovoc#c_29621 http://www.fao.org/aos/agrovoc#c_34031 http://www.fao.org/aos/agrovoc#c_36803 http://www.fao.org/aos/agrovoc#c_4795 http://www.fao.org/aos/agrovoc#c_542 http://www.fao.org/aos/agrovoc#c_6259 http://www.fao.org/aos/agrovoc#c_7098 Immunoglobulin E - blood IMMUNOLOGICAL FACTORS interleukin-12 Interleukin-12 - metabolism INTERLEUKINE INTERLEUKINS INTERLEUQUINAS Lymphocytes - drug effects Magnoliopsida MALADIE DE LA PEAU Male METHODE D'APPLICATION METODOS DE APLICACION MICE Mice, Inbred Strains NC/Nga mouse OLIGOSACARIDOS OLIGOSACCHARIDE OLIGOSACCHARIDES Oligosaccharides - administration & dosage Oligosaccharides - pharmacology Oligosaccharides - therapeutic use ORAL ADMINISTRATION Phytotherapy Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - therapeutic use prebiotics PROTEINAS PROTEINE PROTEINS RATON Skin - drug effects Skin - immunology Skin - pathology SKIN DISEASES SOURIS Spleen - cytology Vertebrates: anatomy and physiology, studies on body, several organs or systems Wood |
| title | Oral administration of acidic xylooligosaccharides prevents the development of atopic dermatitis-like skin lesions in NC/Nga mice |
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