Short-term feeding of conjugated linoleic acid does not induce hepatic steatosis in C57BL/6J mice
We investigated the effect of short-term feeding of conjugated linoleic acid (CLA) on adipose tissue weights, liver weight, hepatic lipid metabolism, and serum lipoprotein profiles in C57BL/6J mice. Mice were fed semi-synthetic diets containing either 6% high-linoleic safflower oil (HL-SAF) or 4% HL...
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| Veröffentlicht in: | Journal of Nutritional Science and Vitaminology 2005, Vol.51(6), pp.440-444 |
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| container_title | Journal of Nutritional Science and Vitaminology |
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| creator | Wang, Y.M.(Saga Univ. (Japan)) Nagao, K Ujino, Y Sakata, K Higa, K Inoue, N Yanagita, T |
| description | We investigated the effect of short-term feeding of conjugated linoleic acid (CLA) on adipose tissue weights, liver weight, hepatic lipid metabolism, and serum lipoprotein profiles in C57BL/6J mice. Mice were fed semi-synthetic diets containing either 6% high-linoleic safflower oil (HL-SAF) or 4% HL-SAF+2% CLA for 1 wk. Short-term feeding of CLA showed an anti-obesity effect without inducing hepatomegaly in mice. In addition to the decline of hepatic triglyceride concentration, significant inhibition of delta9 desaturation of fatty acid in the total liver lipids was found in CLA-fed mice. The CLA diet significantly increased the activities of peroxisomal beta-oxidation and decreased the activities of diacylglycerol acyltransferase, a triglyceride synthesis-related enzyme, in the liver. Moreover, serum lipoprotein profiles of CLA-fed mice showed preferable changes in the atherogenic indices. However, serum leptin and adiponectin were drastically decreased by CLA feeding, suggesting that prolonged administration of CLA would induce further decrease of serum adipocytokine levels, which may be a cause of lipodystrophy in mice. These results show that short-term feeding of CLA does not induce adverse effect in C57BL/6J mice. |
| doi_str_mv | 10.3177/jnsv.51.440 |
| format | Article |
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(Japan)) ; Nagao, K ; Ujino, Y ; Sakata, K ; Higa, K ; Inoue, N ; Yanagita, T</creator><creatorcontrib>Wang, Y.M.(Saga Univ. (Japan)) ; Nagao, K ; Ujino, Y ; Sakata, K ; Higa, K ; Inoue, N ; Yanagita, T</creatorcontrib><description>We investigated the effect of short-term feeding of conjugated linoleic acid (CLA) on adipose tissue weights, liver weight, hepatic lipid metabolism, and serum lipoprotein profiles in C57BL/6J mice. Mice were fed semi-synthetic diets containing either 6% high-linoleic safflower oil (HL-SAF) or 4% HL-SAF+2% CLA for 1 wk. Short-term feeding of CLA showed an anti-obesity effect without inducing hepatomegaly in mice. In addition to the decline of hepatic triglyceride concentration, significant inhibition of delta9 desaturation of fatty acid in the total liver lipids was found in CLA-fed mice. The CLA diet significantly increased the activities of peroxisomal beta-oxidation and decreased the activities of diacylglycerol acyltransferase, a triglyceride synthesis-related enzyme, in the liver. Moreover, serum lipoprotein profiles of CLA-fed mice showed preferable changes in the atherogenic indices. However, serum leptin and adiponectin were drastically decreased by CLA feeding, suggesting that prolonged administration of CLA would induce further decrease of serum adipocytokine levels, which may be a cause of lipodystrophy in mice. These results show that short-term feeding of CLA does not induce adverse effect in C57BL/6J mice.</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.51.440</identifier><identifier>PMID: 16521704</identifier><language>eng</language><publisher>Tokyo: Center for Academic Publications Japan</publisher><subject>ACIDE LINOLEIQUE ; ACIDO LINOLEICO ; Adipose Tissue - anatomy & histology ; Animals ; Biological and medical sciences ; C57BL/6J mice ; conjugated linoleic acid ; diacylglycerol acyltransferase ; Diacylglycerol O-Acyltransferase - metabolism ; Diet ; ENZIMAS ; ENZYME ; ENZYMES ; Fatty Liver - chemically induced ; Gastroenterology. Liver. Pancreas. Abdomen ; GLICEROL ; GLYCEROL ; hepatic steatosis ; LINOLEIC ACID ; Linoleic Acids, Conjugated - administration & dosage ; Lipid Metabolism - drug effects ; Lipoproteins - blood ; Liver - anatomy & histology ; Liver - metabolism ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; MICE ; Mice, Inbred C57BL ; Obesity - prevention & control ; Organ Size - drug effects ; Other diseases. Semiology ; Oxidation-Reduction ; Peroxisomes - metabolism ; RATON ; Safflower Oil - administration & dosage ; SOURIS</subject><ispartof>Journal of Nutritional Science and Vitaminology, 2005, Vol.51(6), pp.440-444</ispartof><rights>the Center for Academic Publications Japan</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-d03275c9bea489c9d0567a34bc9cfd1e4d3c594d117f85f43adef4f80ca1eca83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17471263$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16521704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Y.M.(Saga Univ. (Japan))</creatorcontrib><creatorcontrib>Nagao, K</creatorcontrib><creatorcontrib>Ujino, Y</creatorcontrib><creatorcontrib>Sakata, K</creatorcontrib><creatorcontrib>Higa, K</creatorcontrib><creatorcontrib>Inoue, N</creatorcontrib><creatorcontrib>Yanagita, T</creatorcontrib><title>Short-term feeding of conjugated linoleic acid does not induce hepatic steatosis in C57BL/6J mice</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>We investigated the effect of short-term feeding of conjugated linoleic acid (CLA) on adipose tissue weights, liver weight, hepatic lipid metabolism, and serum lipoprotein profiles in C57BL/6J mice. Mice were fed semi-synthetic diets containing either 6% high-linoleic safflower oil (HL-SAF) or 4% HL-SAF+2% CLA for 1 wk. Short-term feeding of CLA showed an anti-obesity effect without inducing hepatomegaly in mice. In addition to the decline of hepatic triglyceride concentration, significant inhibition of delta9 desaturation of fatty acid in the total liver lipids was found in CLA-fed mice. The CLA diet significantly increased the activities of peroxisomal beta-oxidation and decreased the activities of diacylglycerol acyltransferase, a triglyceride synthesis-related enzyme, in the liver. Moreover, serum lipoprotein profiles of CLA-fed mice showed preferable changes in the atherogenic indices. However, serum leptin and adiponectin were drastically decreased by CLA feeding, suggesting that prolonged administration of CLA would induce further decrease of serum adipocytokine levels, which may be a cause of lipodystrophy in mice. These results show that short-term feeding of CLA does not induce adverse effect in C57BL/6J mice.</description><subject>ACIDE LINOLEIQUE</subject><subject>ACIDO LINOLEICO</subject><subject>Adipose Tissue - anatomy & histology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>C57BL/6J mice</subject><subject>conjugated linoleic acid</subject><subject>diacylglycerol acyltransferase</subject><subject>Diacylglycerol O-Acyltransferase - metabolism</subject><subject>Diet</subject><subject>ENZIMAS</subject><subject>ENZYME</subject><subject>ENZYMES</subject><subject>Fatty Liver - chemically induced</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>GLICEROL</subject><subject>GLYCEROL</subject><subject>hepatic steatosis</subject><subject>LINOLEIC ACID</subject><subject>Linoleic Acids, Conjugated - administration & dosage</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lipoproteins - blood</subject><subject>Liver - anatomy & histology</subject><subject>Liver - metabolism</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MICE</subject><subject>Mice, Inbred C57BL</subject><subject>Obesity - prevention & control</subject><subject>Organ Size - drug effects</subject><subject>Other diseases. Semiology</subject><subject>Oxidation-Reduction</subject><subject>Peroxisomes - metabolism</subject><subject>RATON</subject><subject>Safflower Oil - administration & dosage</subject><subject>SOURIS</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc-PEyEYhonRuN3Vk2cNF0-b6cIAA3N0689NE03U8-QrfLQ006EBauJ_L3Wa3Qsc3ifvmzwfIW84Wwqu9d1-yn-Wii-lZM_IghvDG61l-5wsmGC8kYaxK3Kd854x2RtpXpIr3qmWayYXBH7uYipNwXSgHtGFaUujpzZO-9MWCjo6himOGCwFGxx1ETOdYqFhcieLdIdHKDXMBaHEHHIN6Erp-_Vd90APweIr8sLDmPH15b8hvz9_-rX62qy_f_m2-rBurGp1aRwTrVa23yBI09veMdVpEHJje-sdR-mEVb10nGtvlJcCHHrpDbPA0YIRN-R27rUp5pzQD8cUDpD-DpwNZ1HDWdSg-FBFVfrdTB9PmwO6J_ZipgLvLwBkC6NPMNmQnzgtNW87UbmPM7fPBbb4CECqWkb8P8p7Lc7D3fzU_cfY7iANONWat3ONhzjANtWphx8tY935aLIX_wA4YpLI</recordid><startdate>20051201</startdate><enddate>20051201</enddate><creator>Wang, Y.M.(Saga Univ. (Japan))</creator><creator>Nagao, K</creator><creator>Ujino, Y</creator><creator>Sakata, K</creator><creator>Higa, K</creator><creator>Inoue, N</creator><creator>Yanagita, T</creator><general>Center for Academic Publications Japan</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20051201</creationdate><title>Short-term feeding of conjugated linoleic acid does not induce hepatic steatosis in C57BL/6J mice</title><author>Wang, Y.M.(Saga Univ. (Japan)) ; Nagao, K ; Ujino, Y ; Sakata, K ; Higa, K ; Inoue, N ; Yanagita, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-d03275c9bea489c9d0567a34bc9cfd1e4d3c594d117f85f43adef4f80ca1eca83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>ACIDE LINOLEIQUE</topic><topic>ACIDO LINOLEICO</topic><topic>Adipose Tissue - anatomy & histology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>C57BL/6J mice</topic><topic>conjugated linoleic acid</topic><topic>diacylglycerol acyltransferase</topic><topic>Diacylglycerol O-Acyltransferase - metabolism</topic><topic>Diet</topic><topic>ENZIMAS</topic><topic>ENZYME</topic><topic>ENZYMES</topic><topic>Fatty Liver - chemically induced</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>GLICEROL</topic><topic>GLYCEROL</topic><topic>hepatic steatosis</topic><topic>LINOLEIC ACID</topic><topic>Linoleic Acids, Conjugated - administration & dosage</topic><topic>Lipid Metabolism - drug effects</topic><topic>Lipoproteins - blood</topic><topic>Liver - anatomy & histology</topic><topic>Liver - metabolism</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MICE</topic><topic>Mice, Inbred C57BL</topic><topic>Obesity - prevention & control</topic><topic>Organ Size - drug effects</topic><topic>Other diseases. Semiology</topic><topic>Oxidation-Reduction</topic><topic>Peroxisomes - metabolism</topic><topic>RATON</topic><topic>Safflower Oil - administration & dosage</topic><topic>SOURIS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Y.M.(Saga Univ. (Japan))</creatorcontrib><creatorcontrib>Nagao, K</creatorcontrib><creatorcontrib>Ujino, Y</creatorcontrib><creatorcontrib>Sakata, K</creatorcontrib><creatorcontrib>Higa, K</creatorcontrib><creatorcontrib>Inoue, N</creatorcontrib><creatorcontrib>Yanagita, T</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Y.M.(Saga Univ. (Japan))</au><au>Nagao, K</au><au>Ujino, Y</au><au>Sakata, K</au><au>Higa, K</au><au>Inoue, N</au><au>Yanagita, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-term feeding of conjugated linoleic acid does not induce hepatic steatosis in C57BL/6J mice</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>2005-12-01</date><risdate>2005</risdate><volume>51</volume><issue>6</issue><spage>440</spage><epage>444</epage><pages>440-444</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>We investigated the effect of short-term feeding of conjugated linoleic acid (CLA) on adipose tissue weights, liver weight, hepatic lipid metabolism, and serum lipoprotein profiles in C57BL/6J mice. Mice were fed semi-synthetic diets containing either 6% high-linoleic safflower oil (HL-SAF) or 4% HL-SAF+2% CLA for 1 wk. Short-term feeding of CLA showed an anti-obesity effect without inducing hepatomegaly in mice. In addition to the decline of hepatic triglyceride concentration, significant inhibition of delta9 desaturation of fatty acid in the total liver lipids was found in CLA-fed mice. The CLA diet significantly increased the activities of peroxisomal beta-oxidation and decreased the activities of diacylglycerol acyltransferase, a triglyceride synthesis-related enzyme, in the liver. Moreover, serum lipoprotein profiles of CLA-fed mice showed preferable changes in the atherogenic indices. However, serum leptin and adiponectin were drastically decreased by CLA feeding, suggesting that prolonged administration of CLA would induce further decrease of serum adipocytokine levels, which may be a cause of lipodystrophy in mice. These results show that short-term feeding of CLA does not induce adverse effect in C57BL/6J mice.</abstract><cop>Tokyo</cop><pub>Center for Academic Publications Japan</pub><pmid>16521704</pmid><doi>10.3177/jnsv.51.440</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Nutritional Science and Vitaminology, 2005, Vol.51(6), pp.440-444 |
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| language | eng |
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| subjects | ACIDE LINOLEIQUE ACIDO LINOLEICO Adipose Tissue - anatomy & histology Animals Biological and medical sciences C57BL/6J mice conjugated linoleic acid diacylglycerol acyltransferase Diacylglycerol O-Acyltransferase - metabolism Diet ENZIMAS ENZYME ENZYMES Fatty Liver - chemically induced Gastroenterology. Liver. Pancreas. Abdomen GLICEROL GLYCEROL hepatic steatosis LINOLEIC ACID Linoleic Acids, Conjugated - administration & dosage Lipid Metabolism - drug effects Lipoproteins - blood Liver - anatomy & histology Liver - metabolism Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences MICE Mice, Inbred C57BL Obesity - prevention & control Organ Size - drug effects Other diseases. Semiology Oxidation-Reduction Peroxisomes - metabolism RATON Safflower Oil - administration & dosage SOURIS |
| title | Short-term feeding of conjugated linoleic acid does not induce hepatic steatosis in C57BL/6J mice |
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