Influence of cigarette smoke on the L-ascorbic acid metabolism and the activities of drug-metabolizing enzyme in rats
This study clarified the influence of cigarette smoke on the L-ascorbic acid (AsA) metabolism and the activities of drug-metabolizing enzyme in rats. The test rats (group T) were exposed to weak sidestream smoke from cigarettes for 2 h, everyday for 5 7 days. AsA concentration in the tissues and exc...
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| Veröffentlicht in: | Journal of Nutritional Science and Vitaminology 2005, Vol.51(5), pp.374-376 |
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| container_title | Journal of Nutritional Science and Vitaminology |
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| creator | Suzuki, E.(Ochanomizu Univ., Tokyo (Japan)) Hayashi, M Kaminao, M Kurata, T |
| description | This study clarified the influence of cigarette smoke on the L-ascorbic acid (AsA) metabolism and the activities of drug-metabolizing enzyme in rats. The test rats (group T) were exposed to weak sidestream smoke from cigarettes for 2 h, everyday for 5 7 days. AsA concentration in the tissues and excreted amount of AsA in urine of group T tended to be higher than those of control group (group C). The plasma AsA concentration and the activities of aniline hydroxylase and 7-ethoxycoumarin 0-deethylase of group T were significantly higher than those of group C. There was no significant difference in the activity of UDP glucuronosyltransferase or in the liver cytochrome P-450 content between these two groups. |
| doi_str_mv | 10.3177/jnsv.51.374 |
| format | Article |
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The test rats (group T) were exposed to weak sidestream smoke from cigarettes for 2 h, everyday for 5 7 days. AsA concentration in the tissues and excreted amount of AsA in urine of group T tended to be higher than those of control group (group C). The plasma AsA concentration and the activities of aniline hydroxylase and 7-ethoxycoumarin 0-deethylase of group T were significantly higher than those of group C. There was no significant difference in the activity of UDP glucuronosyltransferase or in the liver cytochrome P-450 content between these two groups.</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.51.374</identifier><identifier>PMID: 16392710</identifier><language>eng</language><publisher>Tokyo: Center for Academic Publications Japan</publisher><subject>7-Alkoxycoumarin O-Dealkylase - metabolism ; ACIDE ASCORBIQUE ; ACIDO ASCORBICO ; Adrenal Glands - metabolism ; Aniline Hydroxylase - metabolism ; Animals ; ASCORBIC ACID ; Ascorbic Acid - metabolism ; Biological and medical sciences ; cigarette smoke ; Cytochrome P-450 Enzyme System - metabolism ; drug-metabolizing enzyme ; DRUGS ; Glucuronosyltransferase - metabolism ; Kidney - metabolism ; Liver - enzymology ; Liver - metabolism ; Male ; Medical sciences ; MEDICAMENT ; MEDICAMENTOS ; METABOLISM ; METABOLISME ; METABOLISMO ; RAT ; RATA ; RATS ; Rats, Wistar ; TABAC ; TABACO ; Time Factors ; TOBACCO ; Tobacco Smoke Pollution - adverse effects ; Tobacco, tobacco smoking ; Toxicology</subject><ispartof>Journal of Nutritional Science and Vitaminology, 2005, Vol.51(5), pp.374-376</ispartof><rights>the Center for Academic Publications Japan</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17327464$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16392710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suzuki, E.(Ochanomizu Univ., Tokyo (Japan))</creatorcontrib><creatorcontrib>Hayashi, M</creatorcontrib><creatorcontrib>Kaminao, M</creatorcontrib><creatorcontrib>Kurata, T</creatorcontrib><title>Influence of cigarette smoke on the L-ascorbic acid metabolism and the activities of drug-metabolizing enzyme in rats</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>This study clarified the influence of cigarette smoke on the L-ascorbic acid (AsA) metabolism and the activities of drug-metabolizing enzyme in rats. The test rats (group T) were exposed to weak sidestream smoke from cigarettes for 2 h, everyday for 5 7 days. AsA concentration in the tissues and excreted amount of AsA in urine of group T tended to be higher than those of control group (group C). The plasma AsA concentration and the activities of aniline hydroxylase and 7-ethoxycoumarin 0-deethylase of group T were significantly higher than those of group C. There was no significant difference in the activity of UDP glucuronosyltransferase or in the liver cytochrome P-450 content between these two groups.</description><subject>7-Alkoxycoumarin O-Dealkylase - metabolism</subject><subject>ACIDE ASCORBIQUE</subject><subject>ACIDO ASCORBICO</subject><subject>Adrenal Glands - metabolism</subject><subject>Aniline Hydroxylase - metabolism</subject><subject>Animals</subject><subject>ASCORBIC ACID</subject><subject>Ascorbic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>cigarette smoke</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>drug-metabolizing enzyme</subject><subject>DRUGS</subject><subject>Glucuronosyltransferase - metabolism</subject><subject>Kidney - metabolism</subject><subject>Liver - enzymology</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MEDICAMENT</subject><subject>MEDICAMENTOS</subject><subject>METABOLISM</subject><subject>METABOLISME</subject><subject>METABOLISMO</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Wistar</subject><subject>TABAC</subject><subject>TABACO</subject><subject>Time Factors</subject><subject>TOBACCO</subject><subject>Tobacco Smoke Pollution - adverse effects</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v3CAURVHVqJmmXXXdik1XladgsMHLKulHopHSRbu2nvHDYWrjCJhIya8PjqfJBiQ4nPt0IeQDZ1vBlfq69_FuW_GtUPIV2XCteaGULF-TDROMF1IzdkrexrhnTDZa6jfklNeiKRVnG3K49HY8oDdIZ0uNGyBgSkjjNP_LR56mG6S7AqKZQ-cMBeN6OmGCbh5dnCj4_gkBk9ydSw7j4unDYSj-Uw_ODxT9w_2E1HkaIMV35MTCGPH9cT8jf398_3P-q9hd_7w8_7YrTM15KhB1WTaNNpbXRnINTclAGNHbqlNl2fem4Y3CrmZNzaRArioJuq4BLOYXjTgjX1avCXOMAW17G9wE4b7lrF3Ka5fy2oq3ubxMf1rp20M3Yf_CHtvKwOcjkPuA0QbwxsUXTolSyXoRXazcPiYY8BmAkJwZ8Sk0Dy6W4Gpdcv7ztbmB0KLPmo-rxsLcwhBy1NXvkrE6f6RgWjwCbYOaZA</recordid><startdate>20051001</startdate><enddate>20051001</enddate><creator>Suzuki, E.(Ochanomizu Univ., Tokyo (Japan))</creator><creator>Hayashi, M</creator><creator>Kaminao, M</creator><creator>Kurata, T</creator><general>Center for Academic Publications Japan</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20051001</creationdate><title>Influence of cigarette smoke on the L-ascorbic acid metabolism and the activities of drug-metabolizing enzyme in rats</title><author>Suzuki, E.(Ochanomizu Univ., Tokyo (Japan)) ; Hayashi, M ; Kaminao, M ; Kurata, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c611t-ee822998cf16c418a920a3c3df5b722ddc9197eb6096043e1754a866aafe16c93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>7-Alkoxycoumarin O-Dealkylase - metabolism</topic><topic>ACIDE ASCORBIQUE</topic><topic>ACIDO ASCORBICO</topic><topic>Adrenal Glands - metabolism</topic><topic>Aniline Hydroxylase - metabolism</topic><topic>Animals</topic><topic>ASCORBIC ACID</topic><topic>Ascorbic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>cigarette smoke</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>drug-metabolizing enzyme</topic><topic>DRUGS</topic><topic>Glucuronosyltransferase - metabolism</topic><topic>Kidney - metabolism</topic><topic>Liver - enzymology</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MEDICAMENT</topic><topic>MEDICAMENTOS</topic><topic>METABOLISM</topic><topic>METABOLISME</topic><topic>METABOLISMO</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Wistar</topic><topic>TABAC</topic><topic>TABACO</topic><topic>Time Factors</topic><topic>TOBACCO</topic><topic>Tobacco Smoke Pollution - adverse effects</topic><topic>Tobacco, tobacco smoking</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suzuki, E.(Ochanomizu Univ., Tokyo (Japan))</creatorcontrib><creatorcontrib>Hayashi, M</creatorcontrib><creatorcontrib>Kaminao, M</creatorcontrib><creatorcontrib>Kurata, T</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suzuki, E.(Ochanomizu Univ., Tokyo (Japan))</au><au>Hayashi, M</au><au>Kaminao, M</au><au>Kurata, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of cigarette smoke on the L-ascorbic acid metabolism and the activities of drug-metabolizing enzyme in rats</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>2005-10-01</date><risdate>2005</risdate><volume>51</volume><issue>5</issue><spage>374</spage><epage>376</epage><pages>374-376</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>This study clarified the influence of cigarette smoke on the L-ascorbic acid (AsA) metabolism and the activities of drug-metabolizing enzyme in rats. The test rats (group T) were exposed to weak sidestream smoke from cigarettes for 2 h, everyday for 5 7 days. AsA concentration in the tissues and excreted amount of AsA in urine of group T tended to be higher than those of control group (group C). The plasma AsA concentration and the activities of aniline hydroxylase and 7-ethoxycoumarin 0-deethylase of group T were significantly higher than those of group C. There was no significant difference in the activity of UDP glucuronosyltransferase or in the liver cytochrome P-450 content between these two groups.</abstract><cop>Tokyo</cop><pub>Center for Academic Publications Japan</pub><pmid>16392710</pmid><doi>10.3177/jnsv.51.374</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 7-Alkoxycoumarin O-Dealkylase - metabolism ACIDE ASCORBIQUE ACIDO ASCORBICO Adrenal Glands - metabolism Aniline Hydroxylase - metabolism Animals ASCORBIC ACID Ascorbic Acid - metabolism Biological and medical sciences cigarette smoke Cytochrome P-450 Enzyme System - metabolism drug-metabolizing enzyme DRUGS Glucuronosyltransferase - metabolism Kidney - metabolism Liver - enzymology Liver - metabolism Male Medical sciences MEDICAMENT MEDICAMENTOS METABOLISM METABOLISME METABOLISMO RAT RATA RATS Rats, Wistar TABAC TABACO Time Factors TOBACCO Tobacco Smoke Pollution - adverse effects Tobacco, tobacco smoking Toxicology |
| title | Influence of cigarette smoke on the L-ascorbic acid metabolism and the activities of drug-metabolizing enzyme in rats |
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