Soy isoflavone supplementation alleviates oxidative stress and improves systolic blood pressure in male spontaneously hypertensive rats
The aim of this study was to investigate the protective effect of isoflavone against hypertension, via the mitigation of oxidative stress and prevention of nitric oxide (NO, a potent vasodilator) reduction, in spontaneously hypertensive rats (SHR). The 8 wk old male SHR were divided into two groups,...
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| Veröffentlicht in: | Journal of Nutritional Science and Vitaminology 2005, Vol.51(4), pp.254-259 |
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| creator | Park, E.(Kyungnam Univ., Masan (Korea R.)) Shin, J.I Park, O.J Kang, M.H |
| description | The aim of this study was to investigate the protective effect of isoflavone against hypertension, via the mitigation of oxidative stress and prevention of nitric oxide (NO, a potent vasodilator) reduction, in spontaneously hypertensive rats (SHR). The 8 wk old male SHR were divided into two groups, and fed a casein-based high fat diet (120 g fat, 1 g cholesterol/kg diet) for 30 d, either with or without 10 g of soy powder (containing 31.2% of isoflavones)/kg. During the 30-d study period, tail systolic blood pressures (BP) in the control SHR group increased, from 162.4+-2.3 to 1 77+-5.4 mmHg (p0.05), while the isoflavone-supplemented group benefited from a clear antihypertensive effect (160.1+-l.8 to 160.2+-4.9 mmHg). The serum NO and total radical trapping antioxidant potential (TRAP) were elevated in the isoflavone group. The isoflavone group also experienced a significant decrease in oxidative DNA damage in leukocytes, using comet assay. DNA damage correlated positively with incremental BP during the study, and systolic BP at the end of the study (p0.01). Our results indicate that soy isoflavone has an antihypertensive effect, possibly through the amelioration of oxidative stress, and the augmentation of NO production, in SHR. |
| doi_str_mv | 10.3177/jnsv.51.254 |
| format | Article |
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The 8 wk old male SHR were divided into two groups, and fed a casein-based high fat diet (120 g fat, 1 g cholesterol/kg diet) for 30 d, either with or without 10 g of soy powder (containing 31.2% of isoflavones)/kg. During the 30-d study period, tail systolic blood pressures (BP) in the control SHR group increased, from 162.4+-2.3 to 1 77+-5.4 mmHg (p0.05), while the isoflavone-supplemented group benefited from a clear antihypertensive effect (160.1+-l.8 to 160.2+-4.9 mmHg). The serum NO and total radical trapping antioxidant potential (TRAP) were elevated in the isoflavone group. The isoflavone group also experienced a significant decrease in oxidative DNA damage in leukocytes, using comet assay. DNA damage correlated positively with incremental BP during the study, and systolic BP at the end of the study (p0.01). Our results indicate that soy isoflavone has an antihypertensive effect, possibly through the amelioration of oxidative stress, and the augmentation of NO production, in SHR.</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.51.254</identifier><identifier>PMID: 16261997</identifier><language>eng</language><publisher>Tokyo: Center for Academic Publications Japan</publisher><subject>ADN ; ALIMENT A BASE DE SOJA POUR HOMME ; ALIMENTOS DERIVADOS DE LA SOJA ; Animals ; Antihypertensive Agents ; antioxidant ; ANTIOXIDANTES ; ANTIOXIDANTS ; Antioxidants - analysis ; ANTIOXYDANT ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Caseins - administration & dosage ; Diet ; Dietary Fats - administration & dosage ; Dietary Supplements ; DNA ; DNA damage ; DNA Damage - drug effects ; Experimental diseases ; FLAVONOIDE ; FLAVONOIDES ; FLAVONOIDS ; Glycine max - chemistry ; HIPERTENSION ; HYPERTENSION ; Hypertension - drug therapy ; Isoflavones - administration & dosage ; Male ; Medical sciences ; NITRIC OXIDE ; Nitric Oxide - blood ; Oxidative Stress - drug effects ; OXIDO NITRICO ; OXYDE NITRIQUE ; RAT ; RATA ; RATS ; Rats, Inbred SHR ; soy-isoflavones ; SOYFOODS</subject><ispartof>Journal of Nutritional Science and Vitaminology, 2005, Vol.51(4), pp.254-259</ispartof><rights>the Center for Academic Publications Japan</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-4c2c385b07fda931ea7bb170b39144aa9ed6d9a23e410f399f7de3aa90dc7c7b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17570257$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16261997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, E.(Kyungnam Univ., Masan (Korea R.))</creatorcontrib><creatorcontrib>Shin, J.I</creatorcontrib><creatorcontrib>Park, O.J</creatorcontrib><creatorcontrib>Kang, M.H</creatorcontrib><title>Soy isoflavone supplementation alleviates oxidative stress and improves systolic blood pressure in male spontaneously hypertensive rats</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>The aim of this study was to investigate the protective effect of isoflavone against hypertension, via the mitigation of oxidative stress and prevention of nitric oxide (NO, a potent vasodilator) reduction, in spontaneously hypertensive rats (SHR). The 8 wk old male SHR were divided into two groups, and fed a casein-based high fat diet (120 g fat, 1 g cholesterol/kg diet) for 30 d, either with or without 10 g of soy powder (containing 31.2% of isoflavones)/kg. During the 30-d study period, tail systolic blood pressures (BP) in the control SHR group increased, from 162.4+-2.3 to 1 77+-5.4 mmHg (p0.05), while the isoflavone-supplemented group benefited from a clear antihypertensive effect (160.1+-l.8 to 160.2+-4.9 mmHg). The serum NO and total radical trapping antioxidant potential (TRAP) were elevated in the isoflavone group. The isoflavone group also experienced a significant decrease in oxidative DNA damage in leukocytes, using comet assay. DNA damage correlated positively with incremental BP during the study, and systolic BP at the end of the study (p0.01). Our results indicate that soy isoflavone has an antihypertensive effect, possibly through the amelioration of oxidative stress, and the augmentation of NO production, in SHR.</description><subject>ADN</subject><subject>ALIMENT A BASE DE SOJA POUR HOMME</subject><subject>ALIMENTOS DERIVADOS DE LA SOJA</subject><subject>Animals</subject><subject>Antihypertensive Agents</subject><subject>antioxidant</subject><subject>ANTIOXIDANTES</subject><subject>ANTIOXIDANTS</subject><subject>Antioxidants - analysis</subject><subject>ANTIOXYDANT</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Caseins - administration & dosage</subject><subject>Diet</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Supplements</subject><subject>DNA</subject><subject>DNA damage</subject><subject>DNA Damage - drug effects</subject><subject>Experimental diseases</subject><subject>FLAVONOIDE</subject><subject>FLAVONOIDES</subject><subject>FLAVONOIDS</subject><subject>Glycine max - chemistry</subject><subject>HIPERTENSION</subject><subject>HYPERTENSION</subject><subject>Hypertension - drug therapy</subject><subject>Isoflavones - administration & dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>NITRIC OXIDE</subject><subject>Nitric Oxide - blood</subject><subject>Oxidative Stress - drug effects</subject><subject>OXIDO NITRICO</subject><subject>OXYDE NITRIQUE</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Inbred SHR</subject><subject>soy-isoflavones</subject><subject>SOYFOODS</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1u1DAURiMEotPCijXIG1ZVBjt2xvESlX9VAglYRzfOTeuRY0e2JyJPwGvjkFG7saV7j88nfS6KV4zuOZPy3dHFeV-zfVWLJ8WONQ0rpRTV02JHOWWlaCi9KC5jPFIqVCOa58UFO1QHppTcFX9_-oWY6AcLs3dI4mmaLI7oEiTjHQFrcTaQMBL_x_R5OGcoBYyRgOuJGafg57yNS0zeGk06631PppU4BSTGkRFsfjP57HToT9Eu5H6ZMCR0cdUFSPFF8WwAG_Hl-b4qfn_6-OvmS3n7_fPXm_e3pa4bkUqhK82buqNy6EFxhiC7jknaccWEAFDYH3oFFUfB6MCVGmSPPM9pr6WWHb8qrjevDj7GgEM7BTNCWFpG27XOdq2zrVmb68z0m42eTt2I_SN77i8Db88ARA12COC0iY-crCWt6pX7sHHHmOAOHwAIyWiL_0NZ9q3BYjty_sNa30No0WXN600zgG_hLuSobz8qSg_5aytF-T-6fKTy</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Park, E.(Kyungnam Univ., Masan (Korea R.))</creator><creator>Shin, J.I</creator><creator>Park, O.J</creator><creator>Kang, M.H</creator><general>Center for Academic Publications Japan</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20050801</creationdate><title>Soy isoflavone supplementation alleviates oxidative stress and improves systolic blood pressure in male spontaneously hypertensive rats</title><author>Park, E.(Kyungnam Univ., Masan (Korea R.)) ; Shin, J.I ; Park, O.J ; Kang, M.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-4c2c385b07fda931ea7bb170b39144aa9ed6d9a23e410f399f7de3aa90dc7c7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>ADN</topic><topic>ALIMENT A BASE DE SOJA POUR HOMME</topic><topic>ALIMENTOS DERIVADOS DE LA SOJA</topic><topic>Animals</topic><topic>Antihypertensive Agents</topic><topic>antioxidant</topic><topic>ANTIOXIDANTES</topic><topic>ANTIOXIDANTS</topic><topic>Antioxidants - analysis</topic><topic>ANTIOXYDANT</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Caseins - administration & dosage</topic><topic>Diet</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Supplements</topic><topic>DNA</topic><topic>DNA damage</topic><topic>DNA Damage - drug effects</topic><topic>Experimental diseases</topic><topic>FLAVONOIDE</topic><topic>FLAVONOIDES</topic><topic>FLAVONOIDS</topic><topic>Glycine max - chemistry</topic><topic>HIPERTENSION</topic><topic>HYPERTENSION</topic><topic>Hypertension - drug therapy</topic><topic>Isoflavones - administration & dosage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>NITRIC OXIDE</topic><topic>Nitric Oxide - blood</topic><topic>Oxidative Stress - drug effects</topic><topic>OXIDO NITRICO</topic><topic>OXYDE NITRIQUE</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Inbred SHR</topic><topic>soy-isoflavones</topic><topic>SOYFOODS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, E.(Kyungnam Univ., Masan (Korea R.))</creatorcontrib><creatorcontrib>Shin, J.I</creatorcontrib><creatorcontrib>Park, O.J</creatorcontrib><creatorcontrib>Kang, M.H</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, E.(Kyungnam Univ., Masan (Korea R.))</au><au>Shin, J.I</au><au>Park, O.J</au><au>Kang, M.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soy isoflavone supplementation alleviates oxidative stress and improves systolic blood pressure in male spontaneously hypertensive rats</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>51</volume><issue>4</issue><spage>254</spage><epage>259</epage><pages>254-259</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>The aim of this study was to investigate the protective effect of isoflavone against hypertension, via the mitigation of oxidative stress and prevention of nitric oxide (NO, a potent vasodilator) reduction, in spontaneously hypertensive rats (SHR). The 8 wk old male SHR were divided into two groups, and fed a casein-based high fat diet (120 g fat, 1 g cholesterol/kg diet) for 30 d, either with or without 10 g of soy powder (containing 31.2% of isoflavones)/kg. During the 30-d study period, tail systolic blood pressures (BP) in the control SHR group increased, from 162.4+-2.3 to 1 77+-5.4 mmHg (p0.05), while the isoflavone-supplemented group benefited from a clear antihypertensive effect (160.1+-l.8 to 160.2+-4.9 mmHg). The serum NO and total radical trapping antioxidant potential (TRAP) were elevated in the isoflavone group. The isoflavone group also experienced a significant decrease in oxidative DNA damage in leukocytes, using comet assay. DNA damage correlated positively with incremental BP during the study, and systolic BP at the end of the study (p0.01). Our results indicate that soy isoflavone has an antihypertensive effect, possibly through the amelioration of oxidative stress, and the augmentation of NO production, in SHR.</abstract><cop>Tokyo</cop><pub>Center for Academic Publications Japan</pub><pmid>16261997</pmid><doi>10.3177/jnsv.51.254</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | ADN ALIMENT A BASE DE SOJA POUR HOMME ALIMENTOS DERIVADOS DE LA SOJA Animals Antihypertensive Agents antioxidant ANTIOXIDANTES ANTIOXIDANTS Antioxidants - analysis ANTIOXYDANT Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Caseins - administration & dosage Diet Dietary Fats - administration & dosage Dietary Supplements DNA DNA damage DNA Damage - drug effects Experimental diseases FLAVONOIDE FLAVONOIDES FLAVONOIDS Glycine max - chemistry HIPERTENSION HYPERTENSION Hypertension - drug therapy Isoflavones - administration & dosage Male Medical sciences NITRIC OXIDE Nitric Oxide - blood Oxidative Stress - drug effects OXIDO NITRICO OXYDE NITRIQUE RAT RATA RATS Rats, Inbred SHR soy-isoflavones SOYFOODS |
| title | Soy isoflavone supplementation alleviates oxidative stress and improves systolic blood pressure in male spontaneously hypertensive rats |
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