Expressional Changes of Neuropeptide Y and Cholecystokinin in the Arcuate and Paraventricular Nuclei after Capsaicin Administration
Despite its toxicity, a great deal of attention has been paid to the anorexic effect of capsaicin in the treatment of obesity-related neurotransmitters/neuromodulators. To determine if capsaicin has any effects on the orexigenic or anorexigenic peptides, the neuropeptide Y (NPY) and cholecystokinin...
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| Veröffentlicht in: | Journal of Nutritional Science and Vitaminology 2004, Vol.50(2), pp.144-148 |
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| container_title | Journal of Nutritional Science and Vitaminology |
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| creator | LEE, In Se NAM, Young Sam LEE, Choong Hyun CHUNG, Dae Won YOON, Yeo Sung KIM, Jin Sang YI, Seong Joon PAI, Tongkun LEE, Heungshik S. |
| description | Despite its toxicity, a great deal of attention has been paid to the anorexic effect of capsaicin in the treatment of obesity-related neurotransmitters/neuromodulators. To determine if capsaicin has any effects on the orexigenic or anorexigenic peptides, the neuropeptide Y (NPY) and cholecystokinin (CCK)-imunoreactivities were demonstrated in the rat hypothalamus by immunohistochemistry after capsaicin administration. There was a significantly lower concentration of NPY immunopositive cells in the arcuate and paraventricular nuclei of the capsaicin treated rats. In contrast, the CCK expressions level was higher in the paraventricular nucleus of the capsaicin treated rats than in the control rats. These results suggest that capsaicin influence neuropeptides such as orexigenic NPY and anorexigenic CCK related to control food intake. |
| doi_str_mv | 10.3177/jnsv.50.144 |
| format | Article |
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To determine if capsaicin has any effects on the orexigenic or anorexigenic peptides, the neuropeptide Y (NPY) and cholecystokinin (CCK)-imunoreactivities were demonstrated in the rat hypothalamus by immunohistochemistry after capsaicin administration. There was a significantly lower concentration of NPY immunopositive cells in the arcuate and paraventricular nuclei of the capsaicin treated rats. In contrast, the CCK expressions level was higher in the paraventricular nucleus of the capsaicin treated rats than in the control rats. These results suggest that capsaicin influence neuropeptides such as orexigenic NPY and anorexigenic CCK related to control food intake.</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.50.144</identifier><identifier>PMID: 15242019</identifier><language>eng</language><publisher>Tokyo: Center for Academic Publications Japan</publisher><subject>Animals ; arcuate nucleus ; Arcuate Nucleus of Hypothalamus - chemistry ; Arcuate Nucleus of Hypothalamus - drug effects ; Biological and medical sciences ; capsaicin ; Capsaicin - pharmacology ; cholecystokinin ; Cholecystokinin - analysis ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Immunohistochemistry ; Male ; Neurons - chemistry ; neuropeptide Y ; Neuropeptide Y - analysis ; Paraventricular Hypothalamic Nucleus - chemistry ; Paraventricular Hypothalamic Nucleus - drug effects ; paraventricular nucleus ; Rats ; Rats, Sprague-Dawley ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of Nutritional Science and Vitaminology, 2004, Vol.50(2), pp.144-148</ispartof><rights>the Center for Academic Publications Japan</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-e2fa591403aad7981c50a9bf2a9cb1af9f847d633918d31dedbbfee36e44b2343</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15883844$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15242019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEE, In Se</creatorcontrib><creatorcontrib>NAM, Young Sam</creatorcontrib><creatorcontrib>LEE, Choong Hyun</creatorcontrib><creatorcontrib>CHUNG, Dae Won</creatorcontrib><creatorcontrib>YOON, Yeo Sung</creatorcontrib><creatorcontrib>KIM, Jin Sang</creatorcontrib><creatorcontrib>YI, Seong Joon</creatorcontrib><creatorcontrib>PAI, Tongkun</creatorcontrib><creatorcontrib>LEE, Heungshik S.</creatorcontrib><title>Expressional Changes of Neuropeptide Y and Cholecystokinin in the Arcuate and Paraventricular Nuclei after Capsaicin Administration</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>Despite its toxicity, a great deal of attention has been paid to the anorexic effect of capsaicin in the treatment of obesity-related neurotransmitters/neuromodulators. To determine if capsaicin has any effects on the orexigenic or anorexigenic peptides, the neuropeptide Y (NPY) and cholecystokinin (CCK)-imunoreactivities were demonstrated in the rat hypothalamus by immunohistochemistry after capsaicin administration. There was a significantly lower concentration of NPY immunopositive cells in the arcuate and paraventricular nuclei of the capsaicin treated rats. In contrast, the CCK expressions level was higher in the paraventricular nucleus of the capsaicin treated rats than in the control rats. These results suggest that capsaicin influence neuropeptides such as orexigenic NPY and anorexigenic CCK related to control food intake.</description><subject>Animals</subject><subject>arcuate nucleus</subject><subject>Arcuate Nucleus of Hypothalamus - chemistry</subject><subject>Arcuate Nucleus of Hypothalamus - drug effects</subject><subject>Biological and medical sciences</subject><subject>capsaicin</subject><subject>Capsaicin - pharmacology</subject><subject>cholecystokinin</subject><subject>Cholecystokinin - analysis</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Neurons - chemistry</subject><subject>neuropeptide Y</subject><subject>Neuropeptide Y - analysis</subject><subject>Paraventricular Hypothalamic Nucleus - chemistry</subject><subject>Paraventricular Hypothalamic Nucleus - drug effects</subject><subject>paraventricular nucleus</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkD1vFDEQhi1ERI5ARY_cUKG92Gtv1i5PR_iQoiQFFFSrWXuc87HnXdneiNT8cXwfCkjWuJhn3ld6CHnH2VLwtr3chvS4bNiSS_mCLLhSvGpbWb8kCyYYr6Ri7Jy8TmnLmNRKqlfknDe1rBnXC_Ln-vcUMSU_BhjoegPhARMdHb3FOY4TTtlbpD8pBFu244DmKeXxlw8-0PLyBukqmhkyHpB7iPCIIUdv5gEivZ3NgJ6CyxjpGqYE3pSzld2VhJQj5FL8hpw5GBK-Pf0X5Mfn6-_rr9XN3Zdv69VNZRrV5AprB43mkgkA22rFTcNA964GbXoOTjslW3slhObKCm7R9r1DFFcoZV8LKS7Ix2OuiWNKEV03Rb-D-NRx1u1VdnuVXcO6orLQ74_0NPc7tP_Yk7sCfDgBkAwMLkIwPv3HKSXUIejTkdumDA_4DEDMvtg5lHLdin1xfRyl_3ltNhA7DOIvbY6Ybg</recordid><startdate>2004</startdate><enddate>2004</enddate><creator>LEE, In Se</creator><creator>NAM, Young Sam</creator><creator>LEE, Choong Hyun</creator><creator>CHUNG, Dae Won</creator><creator>YOON, Yeo Sung</creator><creator>KIM, Jin Sang</creator><creator>YI, Seong Joon</creator><creator>PAI, Tongkun</creator><creator>LEE, Heungshik S.</creator><general>Center for Academic Publications Japan</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2004</creationdate><title>Expressional Changes of Neuropeptide Y and Cholecystokinin in the Arcuate and Paraventricular Nuclei after Capsaicin Administration</title><author>LEE, In Se ; NAM, Young Sam ; LEE, Choong Hyun ; CHUNG, Dae Won ; YOON, Yeo Sung ; KIM, Jin Sang ; YI, Seong Joon ; PAI, Tongkun ; LEE, Heungshik S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c585t-e2fa591403aad7981c50a9bf2a9cb1af9f847d633918d31dedbbfee36e44b2343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>arcuate nucleus</topic><topic>Arcuate Nucleus of Hypothalamus - chemistry</topic><topic>Arcuate Nucleus of Hypothalamus - drug effects</topic><topic>Biological and medical sciences</topic><topic>capsaicin</topic><topic>Capsaicin - pharmacology</topic><topic>cholecystokinin</topic><topic>Cholecystokinin - analysis</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Neurons - chemistry</topic><topic>neuropeptide Y</topic><topic>Neuropeptide Y - analysis</topic><topic>Paraventricular Hypothalamic Nucleus - chemistry</topic><topic>Paraventricular Hypothalamic Nucleus - drug effects</topic><topic>paraventricular nucleus</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEE, In Se</creatorcontrib><creatorcontrib>NAM, Young Sam</creatorcontrib><creatorcontrib>LEE, Choong Hyun</creatorcontrib><creatorcontrib>CHUNG, Dae Won</creatorcontrib><creatorcontrib>YOON, Yeo Sung</creatorcontrib><creatorcontrib>KIM, Jin Sang</creatorcontrib><creatorcontrib>YI, Seong Joon</creatorcontrib><creatorcontrib>PAI, Tongkun</creatorcontrib><creatorcontrib>LEE, Heungshik S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEE, In Se</au><au>NAM, Young Sam</au><au>LEE, Choong Hyun</au><au>CHUNG, Dae Won</au><au>YOON, Yeo Sung</au><au>KIM, Jin Sang</au><au>YI, Seong Joon</au><au>PAI, Tongkun</au><au>LEE, Heungshik S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expressional Changes of Neuropeptide Y and Cholecystokinin in the Arcuate and Paraventricular Nuclei after Capsaicin Administration</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>2004</date><risdate>2004</risdate><volume>50</volume><issue>2</issue><spage>144</spage><epage>148</epage><pages>144-148</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>Despite its toxicity, a great deal of attention has been paid to the anorexic effect of capsaicin in the treatment of obesity-related neurotransmitters/neuromodulators. To determine if capsaicin has any effects on the orexigenic or anorexigenic peptides, the neuropeptide Y (NPY) and cholecystokinin (CCK)-imunoreactivities were demonstrated in the rat hypothalamus by immunohistochemistry after capsaicin administration. There was a significantly lower concentration of NPY immunopositive cells in the arcuate and paraventricular nuclei of the capsaicin treated rats. In contrast, the CCK expressions level was higher in the paraventricular nucleus of the capsaicin treated rats than in the control rats. These results suggest that capsaicin influence neuropeptides such as orexigenic NPY and anorexigenic CCK related to control food intake.</abstract><cop>Tokyo</cop><pub>Center for Academic Publications Japan</pub><pmid>15242019</pmid><doi>10.3177/jnsv.50.144</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals arcuate nucleus Arcuate Nucleus of Hypothalamus - chemistry Arcuate Nucleus of Hypothalamus - drug effects Biological and medical sciences capsaicin Capsaicin - pharmacology cholecystokinin Cholecystokinin - analysis Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Immunohistochemistry Male Neurons - chemistry neuropeptide Y Neuropeptide Y - analysis Paraventricular Hypothalamic Nucleus - chemistry Paraventricular Hypothalamic Nucleus - drug effects paraventricular nucleus Rats Rats, Sprague-Dawley Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Expressional Changes of Neuropeptide Y and Cholecystokinin in the Arcuate and Paraventricular Nuclei after Capsaicin Administration |
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