L-carnitine changes the levels of insulin-like growth factors (IGFs) and IGF binding proteins in streptozotocin-induced diabetic rat
This study investigated the effects of L-carnitine on insulin-like growth factor-1/2 (IGF-1/2) and insulin-like growth factor binding proteins (IGFBPs) in streptozotocin (STZ)-induced diabetic rats. Each rat in the three L-carnitine-treated groups was injected subcutaneously with L-carnitine, 50 (D5...
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| Veröffentlicht in: | Journal of Nutritional Science and Vitaminology 2001, Vol.47(5), pp.329-334 |
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| creator | Heo, Y.R. (Chonbuk National Univ., Chonju (Korea R.)) Kang, C.W Cha, Y.S |
| description | This study investigated the effects of L-carnitine on insulin-like growth factor-1/2 (IGF-1/2) and insulin-like growth factor binding proteins (IGFBPs) in streptozotocin (STZ)-induced diabetic rats. Each rat in the three L-carnitine-treated groups was injected subcutaneously with L-carnitine, 50 (D50), 100 (D100), or 200 (D200) mg/kg body weight every other day for four weeks, and animals in normal (N) and diabetic (DM) groups received saline by the same method. Diabetic rats had significantly lower carnitine concentrations in serum and liver compared with normal rats. Total carnitine concentrations were increased dose-dependently by carnitine treatment. Total IGF-I in serum from diabetic rats was increased dose-dependently by carnitine treatment, but was statistically significant only in the D200 group. The expression of liver IGF-I mRNA was lower in diabetic rats than in normal rats and increased by L-carnitine treatment. L-Carnitine treatment of diabetic rats had no effect on the levels of IGF-2 in serum, liver, and kidney. Although the levels of IGF-2 in serum and kidney of diabetic rats were increased in comparison with normal rats, IGF-2 mRNA was not expressed in liver. Diabetic rats had markedly lower IGFBP-3 than normal rats did, and IGFBP-3 was increased by L-carnitine treatment. These results demonstrate that L-carnitine treatment of diabetic rats modulates the IGFs/IGFBPs axis. Especially noteworthy is that L-carnitine at a dose of 200 mg/kg/48 h for four weeks was able to restore serum total IGF-1 in STZ-induced diabetic rats to nearly normal levels. |
| doi_str_mv | 10.3177/jnsv.47.329 |
| format | Article |
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(Chonbuk National Univ., Chonju (Korea R.)) ; Kang, C.W ; Cha, Y.S</creator><creatorcontrib>Heo, Y.R. (Chonbuk National Univ., Chonju (Korea R.)) ; Kang, C.W ; Cha, Y.S</creatorcontrib><description>This study investigated the effects of L-carnitine on insulin-like growth factor-1/2 (IGF-1/2) and insulin-like growth factor binding proteins (IGFBPs) in streptozotocin (STZ)-induced diabetic rats. Each rat in the three L-carnitine-treated groups was injected subcutaneously with L-carnitine, 50 (D50), 100 (D100), or 200 (D200) mg/kg body weight every other day for four weeks, and animals in normal (N) and diabetic (DM) groups received saline by the same method. Diabetic rats had significantly lower carnitine concentrations in serum and liver compared with normal rats. Total carnitine concentrations were increased dose-dependently by carnitine treatment. Total IGF-I in serum from diabetic rats was increased dose-dependently by carnitine treatment, but was statistically significant only in the D200 group. The expression of liver IGF-I mRNA was lower in diabetic rats than in normal rats and increased by L-carnitine treatment. L-Carnitine treatment of diabetic rats had no effect on the levels of IGF-2 in serum, liver, and kidney. Although the levels of IGF-2 in serum and kidney of diabetic rats were increased in comparison with normal rats, IGF-2 mRNA was not expressed in liver. Diabetic rats had markedly lower IGFBP-3 than normal rats did, and IGFBP-3 was increased by L-carnitine treatment. These results demonstrate that L-carnitine treatment of diabetic rats modulates the IGFs/IGFBPs axis. Especially noteworthy is that L-carnitine at a dose of 200 mg/kg/48 h for four weeks was able to restore serum total IGF-1 in STZ-induced diabetic rats to nearly normal levels.</description><identifier>ISSN: 0301-4800</identifier><identifier>EISSN: 1881-7742</identifier><identifier>DOI: 10.3177/jnsv.47.329</identifier><identifier>PMID: 11814147</identifier><language>eng</language><publisher>Tokyo: Center for Academic Publications Japan</publisher><subject>Animals ; ANTIBIOTICS ; Biological and medical sciences ; CARNITINE ; Carnitine - blood ; Carnitine - metabolism ; Carnitine - pharmacology ; DIABETES ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; General and cellular metabolism. Vitamins ; IGFBPs ; IGFs ; Injections, Subcutaneous ; INSULIN-LIKE GROWTH FACTOR ; Insulin-Like Growth Factor Binding Proteins - blood ; Insulin-Like Growth Factor Binding Proteins - genetics ; Insulin-Like Growth Factor I - metabolism ; Insulin-Like Growth Factor II - metabolism ; Kidney - metabolism ; Liver - metabolism ; Male ; Medical sciences ; Organ Specificity ; Pharmacology. Drug treatments ; PROTEINS ; Random Allocation ; RATS ; Rats, Sprague-Dawley ; RNA, Messenger - metabolism ; Somatomedins - genetics ; Somatomedins - metabolism</subject><ispartof>Journal of Nutritional Science and Vitaminology, 2001, Vol.47(5), pp.329-334</ispartof><rights>the Center for Academic Publications Japan</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c607t-d18b79d0bd0a7693929151180853206b8a643278538ac2ca08a91af5b6723c8e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13405169$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11814147$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heo, Y.R. (Chonbuk National Univ., Chonju (Korea R.))</creatorcontrib><creatorcontrib>Kang, C.W</creatorcontrib><creatorcontrib>Cha, Y.S</creatorcontrib><title>L-carnitine changes the levels of insulin-like growth factors (IGFs) and IGF binding proteins in streptozotocin-induced diabetic rat</title><title>Journal of Nutritional Science and Vitaminology</title><addtitle>J Nutr Sci Vitaminol</addtitle><description>This study investigated the effects of L-carnitine on insulin-like growth factor-1/2 (IGF-1/2) and insulin-like growth factor binding proteins (IGFBPs) in streptozotocin (STZ)-induced diabetic rats. Each rat in the three L-carnitine-treated groups was injected subcutaneously with L-carnitine, 50 (D50), 100 (D100), or 200 (D200) mg/kg body weight every other day for four weeks, and animals in normal (N) and diabetic (DM) groups received saline by the same method. Diabetic rats had significantly lower carnitine concentrations in serum and liver compared with normal rats. Total carnitine concentrations were increased dose-dependently by carnitine treatment. Total IGF-I in serum from diabetic rats was increased dose-dependently by carnitine treatment, but was statistically significant only in the D200 group. The expression of liver IGF-I mRNA was lower in diabetic rats than in normal rats and increased by L-carnitine treatment. L-Carnitine treatment of diabetic rats had no effect on the levels of IGF-2 in serum, liver, and kidney. Although the levels of IGF-2 in serum and kidney of diabetic rats were increased in comparison with normal rats, IGF-2 mRNA was not expressed in liver. Diabetic rats had markedly lower IGFBP-3 than normal rats did, and IGFBP-3 was increased by L-carnitine treatment. These results demonstrate that L-carnitine treatment of diabetic rats modulates the IGFs/IGFBPs axis. Especially noteworthy is that L-carnitine at a dose of 200 mg/kg/48 h for four weeks was able to restore serum total IGF-1 in STZ-induced diabetic rats to nearly normal levels.</description><subject>Animals</subject><subject>ANTIBIOTICS</subject><subject>Biological and medical sciences</subject><subject>CARNITINE</subject><subject>Carnitine - blood</subject><subject>Carnitine - metabolism</subject><subject>Carnitine - pharmacology</subject><subject>DIABETES</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>General and cellular metabolism. Vitamins</subject><subject>IGFBPs</subject><subject>IGFs</subject><subject>Injections, Subcutaneous</subject><subject>INSULIN-LIKE GROWTH FACTOR</subject><subject>Insulin-Like Growth Factor Binding Proteins - blood</subject><subject>Insulin-Like Growth Factor Binding Proteins - genetics</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Insulin-Like Growth Factor II - metabolism</subject><subject>Kidney - metabolism</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Organ Specificity</subject><subject>Pharmacology. Drug treatments</subject><subject>PROTEINS</subject><subject>Random Allocation</subject><subject>RATS</subject><subject>Rats, Sprague-Dawley</subject><subject>RNA, Messenger - metabolism</subject><subject>Somatomedins - genetics</subject><subject>Somatomedins - metabolism</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtv3CAUhVGVqpmkXXWdiE2lRJWnF4MNXkZ5NVWkdtGurWuMPUwcGAGTql33h5eJR4mEeIjvnsM9EPKRwZIzKb-sXXxaCrnkZfOGLJhSrJBSlAdkARxYIRTAITmKcQ0gGiXUO3LImGKCCbkg_-4LjcHZZJ2heoVuNJGmlaGTeTJTpH6g1sXtZF0x2QdDx-B_pxUdUCcfIj27u72J5xRdT_OOdtb11o10E3wyuS7X0piC2ST_1yevs0omttr0tLfYmWQ1DZjek7cDTtF82K_H5NfN9c_Lr8X999u7y4v8xBpkKnqmOtn00PWAsm54Uzasyq2AqngJdaewFryU-aRQlxpBYcNwqLpallwrw4_J51lXBx9jMEO7CfYRw5-WQbvLst1l2QrZ5iwzfTrTm233aPpXdh9eBj7tAYwapyGg0za-clxAxeqd0NXMrWPC0bwAGHL_k3k2ZY3kO-NqnrL_y3X-ldAal2VOZpkBfYtjyFbffpQAeXBRA_8PU2yeiA</recordid><startdate>2001</startdate><enddate>2001</enddate><creator>Heo, Y.R. (Chonbuk National Univ., Chonju (Korea R.))</creator><creator>Kang, C.W</creator><creator>Cha, Y.S</creator><general>Center for Academic Publications Japan</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2001</creationdate><title>L-carnitine changes the levels of insulin-like growth factors (IGFs) and IGF binding proteins in streptozotocin-induced diabetic rat</title><author>Heo, Y.R. (Chonbuk National Univ., Chonju (Korea R.)) ; Kang, C.W ; Cha, Y.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c607t-d18b79d0bd0a7693929151180853206b8a643278538ac2ca08a91af5b6723c8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>ANTIBIOTICS</topic><topic>Biological and medical sciences</topic><topic>CARNITINE</topic><topic>Carnitine - blood</topic><topic>Carnitine - metabolism</topic><topic>Carnitine - pharmacology</topic><topic>DIABETES</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>General and cellular metabolism. Vitamins</topic><topic>IGFBPs</topic><topic>IGFs</topic><topic>Injections, Subcutaneous</topic><topic>INSULIN-LIKE GROWTH FACTOR</topic><topic>Insulin-Like Growth Factor Binding Proteins - blood</topic><topic>Insulin-Like Growth Factor Binding Proteins - genetics</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Insulin-Like Growth Factor II - metabolism</topic><topic>Kidney - metabolism</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Organ Specificity</topic><topic>Pharmacology. Drug treatments</topic><topic>PROTEINS</topic><topic>Random Allocation</topic><topic>RATS</topic><topic>Rats, Sprague-Dawley</topic><topic>RNA, Messenger - metabolism</topic><topic>Somatomedins - genetics</topic><topic>Somatomedins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heo, Y.R. (Chonbuk National Univ., Chonju (Korea R.))</creatorcontrib><creatorcontrib>Kang, C.W</creatorcontrib><creatorcontrib>Cha, Y.S</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heo, Y.R. (Chonbuk National Univ., Chonju (Korea R.))</au><au>Kang, C.W</au><au>Cha, Y.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>L-carnitine changes the levels of insulin-like growth factors (IGFs) and IGF binding proteins in streptozotocin-induced diabetic rat</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>2001</date><risdate>2001</risdate><volume>47</volume><issue>5</issue><spage>329</spage><epage>334</epage><pages>329-334</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>This study investigated the effects of L-carnitine on insulin-like growth factor-1/2 (IGF-1/2) and insulin-like growth factor binding proteins (IGFBPs) in streptozotocin (STZ)-induced diabetic rats. Each rat in the three L-carnitine-treated groups was injected subcutaneously with L-carnitine, 50 (D50), 100 (D100), or 200 (D200) mg/kg body weight every other day for four weeks, and animals in normal (N) and diabetic (DM) groups received saline by the same method. Diabetic rats had significantly lower carnitine concentrations in serum and liver compared with normal rats. Total carnitine concentrations were increased dose-dependently by carnitine treatment. Total IGF-I in serum from diabetic rats was increased dose-dependently by carnitine treatment, but was statistically significant only in the D200 group. The expression of liver IGF-I mRNA was lower in diabetic rats than in normal rats and increased by L-carnitine treatment. L-Carnitine treatment of diabetic rats had no effect on the levels of IGF-2 in serum, liver, and kidney. Although the levels of IGF-2 in serum and kidney of diabetic rats were increased in comparison with normal rats, IGF-2 mRNA was not expressed in liver. Diabetic rats had markedly lower IGFBP-3 than normal rats did, and IGFBP-3 was increased by L-carnitine treatment. These results demonstrate that L-carnitine treatment of diabetic rats modulates the IGFs/IGFBPs axis. Especially noteworthy is that L-carnitine at a dose of 200 mg/kg/48 h for four weeks was able to restore serum total IGF-1 in STZ-induced diabetic rats to nearly normal levels.</abstract><cop>Tokyo</cop><pub>Center for Academic Publications Japan</pub><pmid>11814147</pmid><doi>10.3177/jnsv.47.329</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Nutritional Science and Vitaminology, 2001, Vol.47(5), pp.329-334 |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals ANTIBIOTICS Biological and medical sciences CARNITINE Carnitine - blood Carnitine - metabolism Carnitine - pharmacology DIABETES Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - metabolism Disease Models, Animal Dose-Response Relationship, Drug General and cellular metabolism. Vitamins IGFBPs IGFs Injections, Subcutaneous INSULIN-LIKE GROWTH FACTOR Insulin-Like Growth Factor Binding Proteins - blood Insulin-Like Growth Factor Binding Proteins - genetics Insulin-Like Growth Factor I - metabolism Insulin-Like Growth Factor II - metabolism Kidney - metabolism Liver - metabolism Male Medical sciences Organ Specificity Pharmacology. Drug treatments PROTEINS Random Allocation RATS Rats, Sprague-Dawley RNA, Messenger - metabolism Somatomedins - genetics Somatomedins - metabolism |
| title | L-carnitine changes the levels of insulin-like growth factors (IGFs) and IGF binding proteins in streptozotocin-induced diabetic rat |
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