Effect of 3-acetylpyridine on the content of myelin in the rat brain
Ten-week old rats were fed an AIN-76 purified diet ad libitum and were given 3-acetylpyridine which is an antagonistic agent of nicotinic acid. The quantity and composition of myelin in the brain were analyzed after administration of 3-acetylpyridine for 40 days. Body weight, myelin yield, cerebrosi...
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| Veröffentlicht in: | Journal of Nutritional Science and Vitaminology 1983, Vol.29(5), pp.579-587 |
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| container_title | Journal of Nutritional Science and Vitaminology |
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| creator | Nakashima, Y Suzue, R |
| description | Ten-week old rats were fed an AIN-76 purified diet ad libitum and were given 3-acetylpyridine which is an antagonistic agent of nicotinic acid. The quantity and composition of myelin in the brain were analyzed after administration of 3-acetylpyridine for 40 days. Body weight, myelin yield, cerebroside level and specific activity of 2', 3'-cyclic nucleotide-3'-phosphohydrolase in the brain decreased by administration of 3-acetylpyridine. Despite the decreased myelin yield, the proportion of protein and total lipid and the percentage composition of lipid in myelin did not change by administration of 3-acetylpyridine. Therefore, we have concluded that 3-acetylpyridine plays a significant role in the loss of myelin. |
| doi_str_mv | 10.3177/jnsv.29.579 |
| format | Article |
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The quantity and composition of myelin in the brain were analyzed after administration of 3-acetylpyridine for 40 days. Body weight, myelin yield, cerebroside level and specific activity of 2', 3'-cyclic nucleotide-3'-phosphohydrolase in the brain decreased by administration of 3-acetylpyridine. Despite the decreased myelin yield, the proportion of protein and total lipid and the percentage composition of lipid in myelin did not change by administration of 3-acetylpyridine. 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The quantity and composition of myelin in the brain were analyzed after administration of 3-acetylpyridine for 40 days. Body weight, myelin yield, cerebroside level and specific activity of 2', 3'-cyclic nucleotide-3'-phosphohydrolase in the brain decreased by administration of 3-acetylpyridine. Despite the decreased myelin yield, the proportion of protein and total lipid and the percentage composition of lipid in myelin did not change by administration of 3-acetylpyridine. Therefore, we have concluded that 3-acetylpyridine plays a significant role in the loss of myelin.</description><subject>2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism</subject><subject>3-acetylpyridine</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Brain Chemistry - drug effects</subject><subject>cerebroside</subject><subject>Cerebrosides - metabolism</subject><subject>CNP activity</subject><subject>Lipid Metabolism</subject><subject>Male</subject><subject>myelin</subject><subject>Myelin Proteins - metabolism</subject><subject>niacin</subject><subject>Pyridines - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>tryptophan</subject><issn>0301-4800</issn><issn>1881-7742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LAzEQhoMotVZPnsW9y9ZJsrtJjmLrBxQ8aM8hm482pc2WZBX237vtlsIwc3heHpgXoXsMU4oZe96E9DclYloycYHGmHOcM1aQSzQGCjgvOMA1uklpA1AIXvARGlUUi6oQYzSbO2d1mzUuo7nStu22-y5644PNmpC1a5vpJrQ2HCO7zm59yPwAomqzOiofbtGVU9tk7053gpZv85_Xj3zx9f75-rLIdcFZmzNnS22BKuIcUKdwyaghFBxxUNPSYW1wzUxBmYV-eA2YK6MNcVxURgs6QU-DV8cmpWid3Ee_U7GTGOShCnmoQhIh-yr69MOQ3v_WO2vO2dPvPZ8NfJNatbJnrmLr9dYeXVgwevQNq9eesV6rKG3oNY-DxqlGqlX0SS6_CWAKpKQc84r-Aw3ge_M</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Nakashima, Y</creator><creator>Suzue, R</creator><general>Center for Academic Publications Japan</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19830101</creationdate><title>Effect of 3-acetylpyridine on the content of myelin in the rat brain</title><author>Nakashima, Y ; Suzue, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-7fe5ce03a2ff03fa1573d230f2f0b35f1cd1b7d437e07e08b018adcd2f896dc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism</topic><topic>3-acetylpyridine</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Brain Chemistry - drug effects</topic><topic>cerebroside</topic><topic>Cerebrosides - metabolism</topic><topic>CNP activity</topic><topic>Lipid Metabolism</topic><topic>Male</topic><topic>myelin</topic><topic>Myelin Proteins - metabolism</topic><topic>niacin</topic><topic>Pyridines - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>tryptophan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakashima, Y</creatorcontrib><creatorcontrib>Suzue, R</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Journal of Nutritional Science and Vitaminology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakashima, Y</au><au>Suzue, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of 3-acetylpyridine on the content of myelin in the rat brain</atitle><jtitle>Journal of Nutritional Science and Vitaminology</jtitle><addtitle>J Nutr Sci Vitaminol</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>29</volume><issue>5</issue><spage>579</spage><epage>587</epage><pages>579-587</pages><issn>0301-4800</issn><eissn>1881-7742</eissn><abstract>Ten-week old rats were fed an AIN-76 purified diet ad libitum and were given 3-acetylpyridine which is an antagonistic agent of nicotinic acid. The quantity and composition of myelin in the brain were analyzed after administration of 3-acetylpyridine for 40 days. Body weight, myelin yield, cerebroside level and specific activity of 2', 3'-cyclic nucleotide-3'-phosphohydrolase in the brain decreased by administration of 3-acetylpyridine. Despite the decreased myelin yield, the proportion of protein and total lipid and the percentage composition of lipid in myelin did not change by administration of 3-acetylpyridine. Therefore, we have concluded that 3-acetylpyridine plays a significant role in the loss of myelin.</abstract><cop>Japan</cop><pub>Center for Academic Publications Japan</pub><pmid>6319649</pmid><doi>10.3177/jnsv.29.579</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism 3-acetylpyridine Animals Body Weight - drug effects Brain Chemistry - drug effects cerebroside Cerebrosides - metabolism CNP activity Lipid Metabolism Male myelin Myelin Proteins - metabolism niacin Pyridines - pharmacology Rats Rats, Inbred Strains tryptophan |
| title | Effect of 3-acetylpyridine on the content of myelin in the rat brain |
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