Enhanced brain entry of checkpoint-inhibitory therapeutic antibodies facilitated by intraarterial NEO100 in mouse models of brain-localized malignancies

Immune checkpoint-inhibitory therapeutic antibodies have shown striking activity against several types of cancers but are less effective against brain-localized malignancies, in part due to the protective effect of the blood-brain barrier (BBB). The authors hypothesized that intraarterial (IA) deliv...

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Veröffentlicht in:	Journal of neurosurgery 2023-09, Vol.139 (3), p.1-830
Hauptverfasser:	Wang, Weijun, He, Haiping, Zeng, Shan, Cho, Hee-Yeon, Minea, Radu O, Swenson, Steven D, Zheng, Long, Epstein, Alan L, Stathopoulos, Apostolos, Chen, Ligang, Schönthal, Axel H, Chen, Thomas C
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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