Cyclotron production of 101 Pd/ 101m Rh radionuclide generator for radioimmunotherapy

Cyclotron production of 101 Pd/ 101m Rh radionuclide generator for radioimmunotherapy

101m Rh is one of such radionuclides that has been considered as a potential candidate for targeted radiotherapeutic use, due to its nuclear decay and chemical properties. Electrodeposition of rhodium metal on a copper backing was performed in acidic sulphate. The target was bombarded with a current...

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Veröffentlicht in:Kerntechnik (1987) 2011-05, Vol.76 (2), p.131-135
Hauptverfasser: Enferadi, M., Sadeghi, M., Ensaf, M.
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container_title Kerntechnik (1987)
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creator Enferadi, M.
Sadeghi, M.
Ensaf, M.
description 101m Rh is one of such radionuclides that has been considered as a potential candidate for targeted radiotherapeutic use, due to its nuclear decay and chemical properties. Electrodeposition of rhodium metal on a copper backing was performed in acidic sulphate. The target was bombarded with a current intensity of 120 μA (E p = 29 → 25 MeV) for 30 min (60 μAh). Radiochemical methods were investigated to optimize the production of no-carrier-added 101 Pd/ 101m Rh. The use of a cyclotron target with radiochemical processes (i.e. electrodeposition, electrodissolution and ion-exchange column chromatography) were carried out to produce this radionuclide in high-specific activity and radiochemical form suitable for radiopharmaceutical syntheses.
doi_str_mv 10.3139/124.110118
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title Cyclotron production of 101 Pd/ 101m Rh radionuclide generator for radioimmunotherapy
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