Anti-inflammatory activity of chemical constituents from Echinops gracilis (Asteraceae)

The present work concerns the anti-inflammatory activity of chemical constituents isolated from the roots of Echinops gracilis. The anti-inflammatory activity of the ethyl acetate extract as well as compounds 1, 2, and 3 were evaluated using inhibition of protein denaturation and antiproteinase meth...

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Veröffentlicht in:The Journal of Phytopharmacology 2020-06, Vol.9 (3), p.169-174
Hauptverfasser: Lah, Fidèle Castro Weyepe, Tchamgoue, Armelle Deutou, Abdou, Jean Pierre, Kowa, Theodora Kopa, Wabo, Hippolyte Kamdem, Tchinda, Alembert Tiabou, Agbor, Gabriel Agbor, Frédérich, Michel, Dongo, Etienne
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container_issue 3
container_start_page 169
container_title The Journal of Phytopharmacology
container_volume 9
creator Lah, Fidèle Castro Weyepe
Tchamgoue, Armelle Deutou
Abdou, Jean Pierre
Kowa, Theodora Kopa
Wabo, Hippolyte Kamdem
Tchinda, Alembert Tiabou
Agbor, Gabriel Agbor
Frédérich, Michel
Dongo, Etienne
description The present work concerns the anti-inflammatory activity of chemical constituents isolated from the roots of Echinops gracilis. The anti-inflammatory activity of the ethyl acetate extract as well as compounds 1, 2, and 3 were evaluated using inhibition of protein denaturation and antiproteinase methods. Structural elucidation was achieved through analysis of NMR spectra (1H and 13C, 1H1H COSY, HSQC, HMBC) and literature survey. Seven compounds were identified as erythrinasinate (1), vogelate (2), ferulic acid (3), p-coumaric acid (4), ursolic acid (5), oleanolic acid (6), and quercetin (7). All the isolated compounds were reported for the first time from this plant. Ethyl acetate extract showed potent inhibitory activity against protein denaturation (IC50 = 125.54 µg/mL). Erythrinasinate (1) and vogelate (2) showed a significant anti-inflammatory activity with an IC50 value of 469.43 and 413.71 µg/mL, respectively. The results obtained from the ethyl acetate extract can justify the use of E. gracilis roots in traditional medicine for the treatment of rheumatism.
doi_str_mv 10.31254/phyto.2020.9303
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