Dendrimers in anticancer drug delivery: mechanism of interaction of drug and dendrimers
Dendrimers represents a novel class of macromolecules, which are derived from branches upon branches type structural design. Dendrimers are emerging as promising drug-delivery molecule because of their extraordinary properties including membrane interaction, monodispersity, well-defined size, shape...
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| Veröffentlicht in: | Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2016-11, Vol.44 (7), p.1626-1634 |
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| container_title | Artificial cells, nanomedicine, and biotechnology |
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| creator | Singh, Jaspreet Jain, Keerti Mehra, Neelesh Kumar Jain, N. K. |
| description | Dendrimers represents a novel class of macromolecules, which are derived from branches upon branches type structural design. Dendrimers are emerging as promising drug-delivery molecule because of their extraordinary properties including membrane interaction, monodispersity, well-defined size, shape and molecular weight, etc. Drugs interact with dendrimers in three ways; (a) physical encapsulation, (b) electrostatic interactions, and (c) covalent conjugations. Due to compact, globular structure and availability of interior cavity spaces and multiple surface functional groups, drug molecules can be encapsulated both in the interior of the dendrimers (physical encapsulation) as well as attached to the surface functional groups (covalent conjugations). |
| doi_str_mv | 10.3109/21691401.2015.1129625 |
| format | Article |
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| identifier | ISSN: 2169-1401 |
| ispartof | Artificial cells, nanomedicine, and biotechnology, 2016-11, Vol.44 (7), p.1626-1634 |
| issn | 2169-1401 2169-141X |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Anticancer drugs Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Covalence Dendrimers Dendrimers - chemistry Dendrimers - pharmacokinetics Dendrimers - therapeutic use Drug delivery Drug delivery systems Drug Delivery Systems - methods Drug development Electrostatic properties Encapsulation Functional groups generations Humans Macromolecules mechanisms of interaction Molecular structure Molecular weight Neoplasms - drug therapy Neoplasms - metabolism polymers Structural design |
| title | Dendrimers in anticancer drug delivery: mechanism of interaction of drug and dendrimers |
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