Preparation and characterization of spray-dried inhalable powders containing nanoaggregates for pulmonary delivery of anti-tubercular drugs
This study aims to prepare spray-dried inhalable powders containing anti-tubercular drugs-loaded HPMC nanoaggregates for sustained delivery of drugs to the lung. Nanoaggregates were prepared by precipitation technique. Results showed that the powders obtained had excellent aerosolization property. H...
Gespeichert in:
| Veröffentlicht in: | Artificial cells, nanomedicine, and biotechnology nanomedicine, and biotechnology, 2016-01, Vol.44 (1), p.182-187 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 187 |
|---|---|
| container_issue | 1 |
| container_start_page | 182 |
| container_title | Artificial cells, nanomedicine, and biotechnology |
| container_volume | 44 |
| creator | Kaur, Ranjot Garg, Tarun Das Gupta, Umesh Gupta, Pushpa Rath, Goutam Goyal, Amit Kumar |
| description | This study aims to prepare spray-dried inhalable powders containing anti-tubercular drugs-loaded HPMC nanoaggregates for sustained delivery of drugs to the lung. Nanoaggregates were prepared by precipitation technique. Results showed that the powders obtained had excellent aerosolization property. High drug encapsulation efficiency was achieved in HPMC nano aggregates, ranging from 60% to 70%. A single pulmonary dose resulted in therapeutic drug concentrations 40% to 60% in the lungs and in other organs (< 5%) for 24 h. From this study, we can conclude that delivering drugs through pulmonary route is advantageous for local action in lungs. |
| doi_str_mv | 10.3109/21691401.2014.930747 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_3109_21691401_2014_930747</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1760863966</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-ae21d0718ba6bed2ce2fb84acbbb2f9d63930ef4cec1d6c898c75e552024fdc93</originalsourceid><addsrcrecordid>eNp9kcFu1DAQhiMEolXpGyBkiQuXLLbjOPEJoQpapEpwAImbNbEnqSuvHeyk1fIKvDRepe2BA754PPrm98z8VfWa0V3DqHrPmVRMULbjlImdamgnumfV6TFdM8F-Pn-KKTupznO-peX0THateFmdcKEUl0qdVn--JZwhweJiIBAsMTflZRZM7veWjCPJc4JDbZNDS1y4AQ-DRzLHe4spExPDAi64MJEAIcI0JZxgwUzGmMi8-n0MkA7Eond3WIKiCGFx9bIOmMzqIRGb1im_ql6M4DOeP9xn1Y_Pn75fXNXXXy-_XHy8ro1ouqUG5MzSjvUDyAEtN8jHoRdghmHgo7KyKfvAURg0zErTq950LbYtp1yM1qjmrHq36c4p_loxL3rvskHvIWBcs2adpH1RkbKgb_9Bb-OaQulOM8X6VvZ90xRKbJRJMeeEo56T25eZNaP66Jd-9Esf_dKbX6XszYP4OuzRPhU9ulOADxvgQlnlHu5j8lYvcPAxjQmCcfko_58v_gL_Eqhw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1918568833</pqid></control><display><type>article</type><title>Preparation and characterization of spray-dried inhalable powders containing nanoaggregates for pulmonary delivery of anti-tubercular drugs</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Kaur, Ranjot ; Garg, Tarun ; Das Gupta, Umesh ; Gupta, Pushpa ; Rath, Goutam ; Goyal, Amit Kumar</creator><creatorcontrib>Kaur, Ranjot ; Garg, Tarun ; Das Gupta, Umesh ; Gupta, Pushpa ; Rath, Goutam ; Goyal, Amit Kumar</creatorcontrib><description>This study aims to prepare spray-dried inhalable powders containing anti-tubercular drugs-loaded HPMC nanoaggregates for sustained delivery of drugs to the lung. Nanoaggregates were prepared by precipitation technique. Results showed that the powders obtained had excellent aerosolization property. High drug encapsulation efficiency was achieved in HPMC nano aggregates, ranging from 60% to 70%. A single pulmonary dose resulted in therapeutic drug concentrations 40% to 60% in the lungs and in other organs (< 5%) for 24 h. From this study, we can conclude that delivering drugs through pulmonary route is advantageous for local action in lungs.</description><identifier>ISSN: 2169-1401</identifier><identifier>EISSN: 2169-141X</identifier><identifier>DOI: 10.3109/21691401.2014.930747</identifier><identifier>PMID: 24992699</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Administration, Inhalation ; Aggregates ; Animals ; Antitubercular Agents - chemistry ; Antitubercular Agents - pharmacokinetics ; Antitubercular Agents - pharmacology ; Drug Compounding - methods ; Drug delivery ; Drug delivery systems ; Drug Delivery Systems - methods ; Drug Liberation ; Drugs ; Encapsulation ; Female ; HPMC polymer ; Hypromellose Derivatives - chemistry ; Isoniazid - chemistry ; Isoniazid - pharmacokinetics ; Isoniazid - pharmacology ; Lung - drug effects ; Lung - metabolism ; Lungs ; Male ; nanoaggregates ; Nanoparticles - chemistry ; Nanoparticles - ultrastructure ; Nanostructure ; Nasal Sprays ; Organs ; Particle Size ; Powders ; pulmonary drug delivery ; Rats ; Rats, Wistar ; Rifampin - chemistry ; Rifampin - pharmacokinetics ; Rifampin - pharmacology ; spray-dried powders</subject><ispartof>Artificial cells, nanomedicine, and biotechnology, 2016-01, Vol.44 (1), p.182-187</ispartof><rights>2014 Informa Healthcare USA, Inc. 2014</rights><rights>2014 Informa Healthcare USA, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-ae21d0718ba6bed2ce2fb84acbbb2f9d63930ef4cec1d6c898c75e552024fdc93</citedby><cites>FETCH-LOGICAL-c437t-ae21d0718ba6bed2ce2fb84acbbb2f9d63930ef4cec1d6c898c75e552024fdc93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24992699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kaur, Ranjot</creatorcontrib><creatorcontrib>Garg, Tarun</creatorcontrib><creatorcontrib>Das Gupta, Umesh</creatorcontrib><creatorcontrib>Gupta, Pushpa</creatorcontrib><creatorcontrib>Rath, Goutam</creatorcontrib><creatorcontrib>Goyal, Amit Kumar</creatorcontrib><title>Preparation and characterization of spray-dried inhalable powders containing nanoaggregates for pulmonary delivery of anti-tubercular drugs</title><title>Artificial cells, nanomedicine, and biotechnology</title><addtitle>Artif Cells Nanomed Biotechnol</addtitle><description>This study aims to prepare spray-dried inhalable powders containing anti-tubercular drugs-loaded HPMC nanoaggregates for sustained delivery of drugs to the lung. Nanoaggregates were prepared by precipitation technique. Results showed that the powders obtained had excellent aerosolization property. High drug encapsulation efficiency was achieved in HPMC nano aggregates, ranging from 60% to 70%. A single pulmonary dose resulted in therapeutic drug concentrations 40% to 60% in the lungs and in other organs (< 5%) for 24 h. From this study, we can conclude that delivering drugs through pulmonary route is advantageous for local action in lungs.</description><subject>Administration, Inhalation</subject><subject>Aggregates</subject><subject>Animals</subject><subject>Antitubercular Agents - chemistry</subject><subject>Antitubercular Agents - pharmacokinetics</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Drug Compounding - methods</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drug Delivery Systems - methods</subject><subject>Drug Liberation</subject><subject>Drugs</subject><subject>Encapsulation</subject><subject>Female</subject><subject>HPMC polymer</subject><subject>Hypromellose Derivatives - chemistry</subject><subject>Isoniazid - chemistry</subject><subject>Isoniazid - pharmacokinetics</subject><subject>Isoniazid - pharmacology</subject><subject>Lung - drug effects</subject><subject>Lung - metabolism</subject><subject>Lungs</subject><subject>Male</subject><subject>nanoaggregates</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - ultrastructure</subject><subject>Nanostructure</subject><subject>Nasal Sprays</subject><subject>Organs</subject><subject>Particle Size</subject><subject>Powders</subject><subject>pulmonary drug delivery</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rifampin - chemistry</subject><subject>Rifampin - pharmacokinetics</subject><subject>Rifampin - pharmacology</subject><subject>spray-dried powders</subject><issn>2169-1401</issn><issn>2169-141X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhiMEolXpGyBkiQuXLLbjOPEJoQpapEpwAImbNbEnqSuvHeyk1fIKvDRepe2BA754PPrm98z8VfWa0V3DqHrPmVRMULbjlImdamgnumfV6TFdM8F-Pn-KKTupznO-peX0THateFmdcKEUl0qdVn--JZwhweJiIBAsMTflZRZM7veWjCPJc4JDbZNDS1y4AQ-DRzLHe4spExPDAi64MJEAIcI0JZxgwUzGmMi8-n0MkA7Eond3WIKiCGFx9bIOmMzqIRGb1im_ql6M4DOeP9xn1Y_Pn75fXNXXXy-_XHy8ro1ouqUG5MzSjvUDyAEtN8jHoRdghmHgo7KyKfvAURg0zErTq950LbYtp1yM1qjmrHq36c4p_loxL3rvskHvIWBcs2adpH1RkbKgb_9Bb-OaQulOM8X6VvZ90xRKbJRJMeeEo56T25eZNaP66Jd-9Esf_dKbX6XszYP4OuzRPhU9ulOADxvgQlnlHu5j8lYvcPAxjQmCcfko_58v_gL_Eqhw</recordid><startdate>20160102</startdate><enddate>20160102</enddate><creator>Kaur, Ranjot</creator><creator>Garg, Tarun</creator><creator>Das Gupta, Umesh</creator><creator>Gupta, Pushpa</creator><creator>Rath, Goutam</creator><creator>Goyal, Amit Kumar</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160102</creationdate><title>Preparation and characterization of spray-dried inhalable powders containing nanoaggregates for pulmonary delivery of anti-tubercular drugs</title><author>Kaur, Ranjot ; Garg, Tarun ; Das Gupta, Umesh ; Gupta, Pushpa ; Rath, Goutam ; Goyal, Amit Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-ae21d0718ba6bed2ce2fb84acbbb2f9d63930ef4cec1d6c898c75e552024fdc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Inhalation</topic><topic>Aggregates</topic><topic>Animals</topic><topic>Antitubercular Agents - chemistry</topic><topic>Antitubercular Agents - pharmacokinetics</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Drug Compounding - methods</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Drug Delivery Systems - methods</topic><topic>Drug Liberation</topic><topic>Drugs</topic><topic>Encapsulation</topic><topic>Female</topic><topic>HPMC polymer</topic><topic>Hypromellose Derivatives - chemistry</topic><topic>Isoniazid - chemistry</topic><topic>Isoniazid - pharmacokinetics</topic><topic>Isoniazid - pharmacology</topic><topic>Lung - drug effects</topic><topic>Lung - metabolism</topic><topic>Lungs</topic><topic>Male</topic><topic>nanoaggregates</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - ultrastructure</topic><topic>Nanostructure</topic><topic>Nasal Sprays</topic><topic>Organs</topic><topic>Particle Size</topic><topic>Powders</topic><topic>pulmonary drug delivery</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rifampin - chemistry</topic><topic>Rifampin - pharmacokinetics</topic><topic>Rifampin - pharmacology</topic><topic>spray-dried powders</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaur, Ranjot</creatorcontrib><creatorcontrib>Garg, Tarun</creatorcontrib><creatorcontrib>Das Gupta, Umesh</creatorcontrib><creatorcontrib>Gupta, Pushpa</creatorcontrib><creatorcontrib>Rath, Goutam</creatorcontrib><creatorcontrib>Goyal, Amit Kumar</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaur, Ranjot</au><au>Garg, Tarun</au><au>Das Gupta, Umesh</au><au>Gupta, Pushpa</au><au>Rath, Goutam</au><au>Goyal, Amit Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and characterization of spray-dried inhalable powders containing nanoaggregates for pulmonary delivery of anti-tubercular drugs</atitle><jtitle>Artificial cells, nanomedicine, and biotechnology</jtitle><addtitle>Artif Cells Nanomed Biotechnol</addtitle><date>2016-01-02</date><risdate>2016</risdate><volume>44</volume><issue>1</issue><spage>182</spage><epage>187</epage><pages>182-187</pages><issn>2169-1401</issn><eissn>2169-141X</eissn><abstract>This study aims to prepare spray-dried inhalable powders containing anti-tubercular drugs-loaded HPMC nanoaggregates for sustained delivery of drugs to the lung. Nanoaggregates were prepared by precipitation technique. Results showed that the powders obtained had excellent aerosolization property. High drug encapsulation efficiency was achieved in HPMC nano aggregates, ranging from 60% to 70%. A single pulmonary dose resulted in therapeutic drug concentrations 40% to 60% in the lungs and in other organs (< 5%) for 24 h. From this study, we can conclude that delivering drugs through pulmonary route is advantageous for local action in lungs.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>24992699</pmid><doi>10.3109/21691401.2014.930747</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2169-1401 |
| ispartof | Artificial cells, nanomedicine, and biotechnology, 2016-01, Vol.44 (1), p.182-187 |
| issn | 2169-1401 2169-141X |
| language | eng |
| recordid | cdi_crossref_primary_10_3109_21691401_2014_930747 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Administration, Inhalation Aggregates Animals Antitubercular Agents - chemistry Antitubercular Agents - pharmacokinetics Antitubercular Agents - pharmacology Drug Compounding - methods Drug delivery Drug delivery systems Drug Delivery Systems - methods Drug Liberation Drugs Encapsulation Female HPMC polymer Hypromellose Derivatives - chemistry Isoniazid - chemistry Isoniazid - pharmacokinetics Isoniazid - pharmacology Lung - drug effects Lung - metabolism Lungs Male nanoaggregates Nanoparticles - chemistry Nanoparticles - ultrastructure Nanostructure Nasal Sprays Organs Particle Size Powders pulmonary drug delivery Rats Rats, Wistar Rifampin - chemistry Rifampin - pharmacokinetics Rifampin - pharmacology spray-dried powders |
| title | Preparation and characterization of spray-dried inhalable powders containing nanoaggregates for pulmonary delivery of anti-tubercular drugs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T12%3A34%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preparation%20and%20characterization%20of%20spray-dried%20inhalable%20powders%20containing%20nanoaggregates%20for%20pulmonary%20delivery%20of%20anti-tubercular%20drugs&rft.jtitle=Artificial%20cells,%20nanomedicine,%20and%20biotechnology&rft.au=Kaur,%20Ranjot&rft.date=2016-01-02&rft.volume=44&rft.issue=1&rft.spage=182&rft.epage=187&rft.pages=182-187&rft.issn=2169-1401&rft.eissn=2169-141X&rft_id=info:doi/10.3109/21691401.2014.930747&rft_dat=%3Cproquest_cross%3E1760863966%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1918568833&rft_id=info:pmid/24992699&rfr_iscdi=true |