Bone changes after castration in rats. A model for osteoporosis
Bone changes 6-12 weeks after castration have been studied in 25 female and 27 male middle-aged rats. Castrated female rats gained more weight than their controls, but had decreased bone density and calcium and hydroxyproline content per cm3 bone volume of tibia. Castrated male rats did not differ f...
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| Veröffentlicht in: | Acta orthopaedica 1986, Vol.57 (1), p.67-70 |
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| container_title | Acta orthopaedica |
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| creator | Gürkan, Leyla Ekeland, Arne Gautvik, Kaare M. Langeland, Norvald Rønningen, Helge Solheim, Ludvig F. |
| description | Bone changes 6-12 weeks after castration have been studied in 25 female and 27 male middle-aged rats. Castrated female rats gained more weight than their controls, but had decreased bone density and calcium and hydroxyproline content per cm3 bone volume of tibia. Castrated male rats did not differ from controls regarding body weight and the bone parameters. No influence of castration on the mechanical strength of the femora could be detected in either sex. At 2 weeks after castration, the circulating levels of immunoreactive calcitonin (iCT) were decreased in female rats compared to controls. In contrast, iCT was increased both in castrated male and female rats 10 weeks later. We conclude that castration of 6-month-old female rats causes osteoporosis, and therefore represents a promising experimental model for studying postmenopausal bone loss. |
| doi_str_mv | 10.3109/17453678608993219 |
| format | Article |
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A model for osteoporosis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Gürkan, Leyla ; Ekeland, Arne ; Gautvik, Kaare M. ; Langeland, Norvald ; Rønningen, Helge ; Solheim, Ludvig F.</creator><creatorcontrib>Gürkan, Leyla ; Ekeland, Arne ; Gautvik, Kaare M. ; Langeland, Norvald ; Rønningen, Helge ; Solheim, Ludvig F.</creatorcontrib><description>Bone changes 6-12 weeks after castration have been studied in 25 female and 27 male middle-aged rats. Castrated female rats gained more weight than their controls, but had decreased bone density and calcium and hydroxyproline content per cm3 bone volume of tibia. Castrated male rats did not differ from controls regarding body weight and the bone parameters. No influence of castration on the mechanical strength of the femora could be detected in either sex. At 2 weeks after castration, the circulating levels of immunoreactive calcitonin (iCT) were decreased in female rats compared to controls. In contrast, iCT was increased both in castrated male and female rats 10 weeks later. We conclude that castration of 6-month-old female rats causes osteoporosis, and therefore represents a promising experimental model for studying postmenopausal bone loss.</description><identifier>ISSN: 1745-3674</identifier><identifier>ISSN: 0001-6470</identifier><identifier>EISSN: 1745-3682</identifier><identifier>DOI: 10.3109/17453678608993219</identifier><identifier>PMID: 3962636</identifier><identifier>CODEN: AOSAAK</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Animals ; Biological and medical sciences ; Body Weight ; Bone and Bones - metabolism ; Bone and Bones - physiology ; Calcitonin - blood ; Calcium - metabolism ; Diseases of the osteoarticular system ; Female ; Hydroxyproline - metabolism ; Male ; Medical sciences ; Orchiectomy ; Osteoporosis - etiology ; Osteoporosis - metabolism ; Osteoporosis - physiopathology ; Osteoporosis. Osteomalacia. Paget disease ; Ovariectomy ; Rats ; Rats, Inbred Strains ; Tensile Strength</subject><ispartof>Acta orthopaedica, 1986, Vol.57 (1), p.67-70</ispartof><rights>1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1986</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-ceacade0cf5beb6454532866881554e51077e704ac2fadf0487534a3fc66494f3</citedby><cites>FETCH-LOGICAL-c430t-ceacade0cf5beb6454532866881554e51077e704ac2fadf0487534a3fc66494f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8644367$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3962636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gürkan, Leyla</creatorcontrib><creatorcontrib>Ekeland, Arne</creatorcontrib><creatorcontrib>Gautvik, Kaare M.</creatorcontrib><creatorcontrib>Langeland, Norvald</creatorcontrib><creatorcontrib>Rønningen, Helge</creatorcontrib><creatorcontrib>Solheim, Ludvig F.</creatorcontrib><title>Bone changes after castration in rats. A model for osteoporosis</title><title>Acta orthopaedica</title><addtitle>Acta Orthop Scand</addtitle><description>Bone changes 6-12 weeks after castration have been studied in 25 female and 27 male middle-aged rats. Castrated female rats gained more weight than their controls, but had decreased bone density and calcium and hydroxyproline content per cm3 bone volume of tibia. Castrated male rats did not differ from controls regarding body weight and the bone parameters. No influence of castration on the mechanical strength of the femora could be detected in either sex. At 2 weeks after castration, the circulating levels of immunoreactive calcitonin (iCT) were decreased in female rats compared to controls. In contrast, iCT was increased both in castrated male and female rats 10 weeks later. We conclude that castration of 6-month-old female rats causes osteoporosis, and therefore represents a promising experimental model for studying postmenopausal bone loss.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Bone and Bones - metabolism</subject><subject>Bone and Bones - physiology</subject><subject>Calcitonin - blood</subject><subject>Calcium - metabolism</subject><subject>Diseases of the osteoarticular system</subject><subject>Female</subject><subject>Hydroxyproline - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Orchiectomy</subject><subject>Osteoporosis - etiology</subject><subject>Osteoporosis - metabolism</subject><subject>Osteoporosis - physiopathology</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Ovariectomy</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Tensile Strength</subject><issn>1745-3674</issn><issn>0001-6470</issn><issn>1745-3682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9LwzAUxYMoU6cfwAchD-JbZ9qkaYqCzOE_GPiiz-UuvXEdbTOTFtm3N2NzIMKecsk953Duj5CLmI14zPKbOBMpl5mSTOU5T-L8gJys_yIuVXK4mzNxTE69XzDGlcjZgAx4LhPJ5Qm5f7AtUj2H9hM9BdOhoxp856CrbEurlobJj-iYNrbEmhrrqPUd2qV11lf-jBwZqD2eb98h-Xh6fJ-8RNO359fJeBppwVkXaQQNJTJt0hnOpEhD70RJqVScpgLTmGUZZkyATgyUhgmVpVwAN1pKkQvDh-R6k7t09qtH3xVN5TXWNbRoe19kgQJnqQzCeCPUoZ93aIqlqxpwqyJmxRpa8Q9a8Fxuw_tZg-XOsaUU9lfbPXgNtXHQ6srvZEoKEQKD7G4jq9qAqYFv6-qy6GBVW_fr4fta3P6xzxHqbq7BYbGwvWsD3j03_AAazJhp</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Gürkan, Leyla</creator><creator>Ekeland, Arne</creator><creator>Gautvik, Kaare M.</creator><creator>Langeland, Norvald</creator><creator>Rønningen, Helge</creator><creator>Solheim, Ludvig F.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>Bone changes after castration in rats. A model for osteoporosis</title><author>Gürkan, Leyla ; Ekeland, Arne ; Gautvik, Kaare M. ; Langeland, Norvald ; Rønningen, Helge ; Solheim, Ludvig F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-ceacade0cf5beb6454532866881554e51077e704ac2fadf0487534a3fc66494f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Bone and Bones - metabolism</topic><topic>Bone and Bones - physiology</topic><topic>Calcitonin - blood</topic><topic>Calcium - metabolism</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Hydroxyproline - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Orchiectomy</topic><topic>Osteoporosis - etiology</topic><topic>Osteoporosis - metabolism</topic><topic>Osteoporosis - physiopathology</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Ovariectomy</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Tensile Strength</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gürkan, Leyla</creatorcontrib><creatorcontrib>Ekeland, Arne</creatorcontrib><creatorcontrib>Gautvik, Kaare M.</creatorcontrib><creatorcontrib>Langeland, Norvald</creatorcontrib><creatorcontrib>Rønningen, Helge</creatorcontrib><creatorcontrib>Solheim, Ludvig F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta orthopaedica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gürkan, Leyla</au><au>Ekeland, Arne</au><au>Gautvik, Kaare M.</au><au>Langeland, Norvald</au><au>Rønningen, Helge</au><au>Solheim, Ludvig F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone changes after castration in rats. A model for osteoporosis</atitle><jtitle>Acta orthopaedica</jtitle><addtitle>Acta Orthop Scand</addtitle><date>1986</date><risdate>1986</risdate><volume>57</volume><issue>1</issue><spage>67</spage><epage>70</epage><pages>67-70</pages><issn>1745-3674</issn><issn>0001-6470</issn><eissn>1745-3682</eissn><coden>AOSAAK</coden><abstract>Bone changes 6-12 weeks after castration have been studied in 25 female and 27 male middle-aged rats. Castrated female rats gained more weight than their controls, but had decreased bone density and calcium and hydroxyproline content per cm3 bone volume of tibia. Castrated male rats did not differ from controls regarding body weight and the bone parameters. No influence of castration on the mechanical strength of the femora could be detected in either sex. At 2 weeks after castration, the circulating levels of immunoreactive calcitonin (iCT) were decreased in female rats compared to controls. In contrast, iCT was increased both in castrated male and female rats 10 weeks later. We conclude that castration of 6-month-old female rats causes osteoporosis, and therefore represents a promising experimental model for studying postmenopausal bone loss.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>3962636</pmid><doi>10.3109/17453678608993219</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1745-3674 |
| ispartof | Acta orthopaedica, 1986, Vol.57 (1), p.67-70 |
| issn | 1745-3674 0001-6470 1745-3682 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Body Weight Bone and Bones - metabolism Bone and Bones - physiology Calcitonin - blood Calcium - metabolism Diseases of the osteoarticular system Female Hydroxyproline - metabolism Male Medical sciences Orchiectomy Osteoporosis - etiology Osteoporosis - metabolism Osteoporosis - physiopathology Osteoporosis. Osteomalacia. Paget disease Ovariectomy Rats Rats, Inbred Strains Tensile Strength |
| title | Bone changes after castration in rats. A model for osteoporosis |
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