CP-MLR/PLS directed QSAR study on the glutaminyl cyclase inhibitory activity of imidazoles: rationales to advance the understanding of activity profile

The glutaminyl cyclase inhibitory activity of a series of imidazoles has been analyzed through combinatorial protocol in multiple linear regressions (CP-MLR) and partial least square using different topological and structural descriptors. The QC activity was found to be correlated with 2D-autocorrel...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2013-06, Vol.28 (3), p.515-522
Hauptverfasser:	Kumar, Viney, Gupta, Manish K., Singh, Gagandip, Prabhakar, Yenamandra S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacyltransferases - antagonists & inhibitors Combinatorial Chemistry Techniques - methods CP-MLR DRAGON descriptors Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Glutaminyl cyclase Humans Imidazoles - chemistry Least-Squares Analysis Linear Models Molecular Structure PLS QSAR Quantitative Structure-Activity Relationship
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