Residual small artery impairment in hypertensive patients with normal albumin-creatinine ratio
Objectives Previous studies have suggested that urine albumin excretion (UAE) mirrors generalized vascular damage; however, it is unclear to which degree UAE mirrors small artery impairment. Design We enrolled 67 patients with uncomplicated essential hypertension (EH) during stable antihypertensive...
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| Veröffentlicht in: | Scandinavian cardiovascular journal : SCJ 2016-05, Vol.50 (3), p.167-171 |
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| creator | Eftekhari, Ashkan Wiggers, Signe Nielsen Mathiassen, Ole Norling Christensen, Kent Lodberg |
| description | Objectives Previous studies have suggested that urine albumin excretion (UAE) mirrors generalized vascular damage; however, it is unclear to which degree UAE mirrors small artery impairment. Design We enrolled 67 patients with uncomplicated essential hypertension (EH) during stable antihypertensive therapy. F-R
min
, ACR on three non-consecutive morning urine samples, pulse wave velocity (PWV), and 24-h ambulatory blood pressure (ABPM) were measured. Results ACR was low (0.39 and 0.30-0.60), but abnormal small artery structure defined as F-R
min
>
mean + 2 standard deviations of normotensive value (1.99 + 1 mmHg min/(ml/100 ml)) was present in 45% (n = 30). The mean F-R
min
was 2.89 ± 0.09 mmHg min/(ml/100 ml). ACR correlated significantly to PWV (r
2
=
0.11; p |
| doi_str_mv | 10.3109/14017431.2016.1152397 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_crossref_primary_10_3109_14017431_2016_1152397</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1792373225</sourcerecordid><originalsourceid>FETCH-LOGICAL-c366t-9e1b61560993e6703273fa16c38e1ad9229a645f06598c983411ef4abd2cbd4d3</originalsourceid><addsrcrecordid>eNp9kE1r3DAQhkVpaJJtf0KLjrl4q5Es2bo1hHxBoBCSa4Vsj1kVWXYlO2H_fWR2k2NPM8w87ww8hHwHthXA9E8oGVSlgC1noLYAkgtdfSJnoCQUnDH1OfeZKVbolJyn9JcxkLWEL-SUq1oqrdkZ-fOIyXWL9TQN1ntq44xxT90wWRcHDDN1ge72E-Z5SO4F6WRnl-eJvrp5R8MYc45a3yyDC0UbMa-DC0hjbsav5KS3PuG3Y92Q55vrp6u74uH37f3V5UPRCqXmQiM0CqRiWgtUFRO8Er0F1YoawXaac21VKXumpK5bXYsSAPvSNh1vm67sxIZcHO5Ocfy3YJrN4FKL3tuA45IMVJqLSnAuMyoPaBvHlCL2ZopusHFvgJlVrXlXa1a15qg2534cXyzNgN1H6t1lBn4dABf61crrGH1nZrv3Y-yjDa1L6_3__XgDh5iJLw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1792373225</pqid></control><display><type>article</type><title>Residual small artery impairment in hypertensive patients with normal albumin-creatinine ratio</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Eftekhari, Ashkan ; Wiggers, Signe Nielsen ; Mathiassen, Ole Norling ; Christensen, Kent Lodberg</creator><creatorcontrib>Eftekhari, Ashkan ; Wiggers, Signe Nielsen ; Mathiassen, Ole Norling ; Christensen, Kent Lodberg</creatorcontrib><description>Objectives Previous studies have suggested that urine albumin excretion (UAE) mirrors generalized vascular damage; however, it is unclear to which degree UAE mirrors small artery impairment. Design We enrolled 67 patients with uncomplicated essential hypertension (EH) during stable antihypertensive therapy. F-R
min
, ACR on three non-consecutive morning urine samples, pulse wave velocity (PWV), and 24-h ambulatory blood pressure (ABPM) were measured. Results ACR was low (0.39 and 0.30-0.60), but abnormal small artery structure defined as F-R
min
>
mean + 2 standard deviations of normotensive value (1.99 + 1 mmHg min/(ml/100 ml)) was present in 45% (n = 30). The mean F-R
min
was 2.89 ± 0.09 mmHg min/(ml/100 ml). ACR correlated significantly to PWV (r
2
=
0.11; p < 0.05) and pulse pressure (r
2
=
0.15; p < 0.001), but not F-R
min
and (r
2
=
0.05, p = 0.07). Conclusions Abnormal microvascular structure was present even in EH patients with low UAE. ACR correlated to arterial stiffness and not to small artery structure; therefore, UEA did not reflect microvascular damage in this population. ACR and F-R
min
thus reflect two distinct types of subclinical organ damage in hypertension.</description><identifier>ISSN: 1401-7431</identifier><identifier>EISSN: 1651-2006</identifier><identifier>DOI: 10.3109/14017431.2016.1152397</identifier><identifier>PMID: 26856990</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Albuminuria - etiology ; Albuminuria - physiopathology ; Antihypertensive Agents - administration & dosage ; Antihypertensive Agents - adverse effects ; Arteries - diagnostic imaging ; Arteries - physiopathology ; Creatinine - analysis ; Essential Hypertension ; Female ; forearm minimum vascular resistance ; Humans ; Hypertension - complications ; Hypertension - diagnosis ; Hypertension - drug therapy ; Hypertension - physiopathology ; Male ; Middle Aged ; Pulse Wave Analysis - methods ; pulse wave velocity ; Renal Elimination ; Reproducibility of Results ; Statistics as Topic ; urine albumin excretion ; Vascular Stiffness</subject><ispartof>Scandinavian cardiovascular journal : SCJ, 2016-05, Vol.50 (3), p.167-171</ispartof><rights>2016 Taylor & Francis 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-9e1b61560993e6703273fa16c38e1ad9229a645f06598c983411ef4abd2cbd4d3</citedby><cites>FETCH-LOGICAL-c366t-9e1b61560993e6703273fa16c38e1ad9229a645f06598c983411ef4abd2cbd4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26856990$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eftekhari, Ashkan</creatorcontrib><creatorcontrib>Wiggers, Signe Nielsen</creatorcontrib><creatorcontrib>Mathiassen, Ole Norling</creatorcontrib><creatorcontrib>Christensen, Kent Lodberg</creatorcontrib><title>Residual small artery impairment in hypertensive patients with normal albumin-creatinine ratio</title><title>Scandinavian cardiovascular journal : SCJ</title><addtitle>Scand Cardiovasc J</addtitle><description>Objectives Previous studies have suggested that urine albumin excretion (UAE) mirrors generalized vascular damage; however, it is unclear to which degree UAE mirrors small artery impairment. Design We enrolled 67 patients with uncomplicated essential hypertension (EH) during stable antihypertensive therapy. F-R
min
, ACR on three non-consecutive morning urine samples, pulse wave velocity (PWV), and 24-h ambulatory blood pressure (ABPM) were measured. Results ACR was low (0.39 and 0.30-0.60), but abnormal small artery structure defined as F-R
min
>
mean + 2 standard deviations of normotensive value (1.99 + 1 mmHg min/(ml/100 ml)) was present in 45% (n = 30). The mean F-R
min
was 2.89 ± 0.09 mmHg min/(ml/100 ml). ACR correlated significantly to PWV (r
2
=
0.11; p < 0.05) and pulse pressure (r
2
=
0.15; p < 0.001), but not F-R
min
and (r
2
=
0.05, p = 0.07). Conclusions Abnormal microvascular structure was present even in EH patients with low UAE. ACR correlated to arterial stiffness and not to small artery structure; therefore, UEA did not reflect microvascular damage in this population. ACR and F-R
min
thus reflect two distinct types of subclinical organ damage in hypertension.</description><subject>Albuminuria - etiology</subject><subject>Albuminuria - physiopathology</subject><subject>Antihypertensive Agents - administration & dosage</subject><subject>Antihypertensive Agents - adverse effects</subject><subject>Arteries - diagnostic imaging</subject><subject>Arteries - physiopathology</subject><subject>Creatinine - analysis</subject><subject>Essential Hypertension</subject><subject>Female</subject><subject>forearm minimum vascular resistance</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Hypertension - diagnosis</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pulse Wave Analysis - methods</subject><subject>pulse wave velocity</subject><subject>Renal Elimination</subject><subject>Reproducibility of Results</subject><subject>Statistics as Topic</subject><subject>urine albumin excretion</subject><subject>Vascular Stiffness</subject><issn>1401-7431</issn><issn>1651-2006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1r3DAQhkVpaJJtf0KLjrl4q5Es2bo1hHxBoBCSa4Vsj1kVWXYlO2H_fWR2k2NPM8w87ww8hHwHthXA9E8oGVSlgC1noLYAkgtdfSJnoCQUnDH1OfeZKVbolJyn9JcxkLWEL-SUq1oqrdkZ-fOIyXWL9TQN1ntq44xxT90wWRcHDDN1ge72E-Z5SO4F6WRnl-eJvrp5R8MYc45a3yyDC0UbMa-DC0hjbsav5KS3PuG3Y92Q55vrp6u74uH37f3V5UPRCqXmQiM0CqRiWgtUFRO8Er0F1YoawXaac21VKXumpK5bXYsSAPvSNh1vm67sxIZcHO5Ocfy3YJrN4FKL3tuA45IMVJqLSnAuMyoPaBvHlCL2ZopusHFvgJlVrXlXa1a15qg2534cXyzNgN1H6t1lBn4dABf61crrGH1nZrv3Y-yjDa1L6_3__XgDh5iJLw</recordid><startdate>20160503</startdate><enddate>20160503</enddate><creator>Eftekhari, Ashkan</creator><creator>Wiggers, Signe Nielsen</creator><creator>Mathiassen, Ole Norling</creator><creator>Christensen, Kent Lodberg</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160503</creationdate><title>Residual small artery impairment in hypertensive patients with normal albumin-creatinine ratio</title><author>Eftekhari, Ashkan ; Wiggers, Signe Nielsen ; Mathiassen, Ole Norling ; Christensen, Kent Lodberg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366t-9e1b61560993e6703273fa16c38e1ad9229a645f06598c983411ef4abd2cbd4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Albuminuria - etiology</topic><topic>Albuminuria - physiopathology</topic><topic>Antihypertensive Agents - administration & dosage</topic><topic>Antihypertensive Agents - adverse effects</topic><topic>Arteries - diagnostic imaging</topic><topic>Arteries - physiopathology</topic><topic>Creatinine - analysis</topic><topic>Essential Hypertension</topic><topic>Female</topic><topic>forearm minimum vascular resistance</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Hypertension - diagnosis</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pulse Wave Analysis - methods</topic><topic>pulse wave velocity</topic><topic>Renal Elimination</topic><topic>Reproducibility of Results</topic><topic>Statistics as Topic</topic><topic>urine albumin excretion</topic><topic>Vascular Stiffness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eftekhari, Ashkan</creatorcontrib><creatorcontrib>Wiggers, Signe Nielsen</creatorcontrib><creatorcontrib>Mathiassen, Ole Norling</creatorcontrib><creatorcontrib>Christensen, Kent Lodberg</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian cardiovascular journal : SCJ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eftekhari, Ashkan</au><au>Wiggers, Signe Nielsen</au><au>Mathiassen, Ole Norling</au><au>Christensen, Kent Lodberg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Residual small artery impairment in hypertensive patients with normal albumin-creatinine ratio</atitle><jtitle>Scandinavian cardiovascular journal : SCJ</jtitle><addtitle>Scand Cardiovasc J</addtitle><date>2016-05-03</date><risdate>2016</risdate><volume>50</volume><issue>3</issue><spage>167</spage><epage>171</epage><pages>167-171</pages><issn>1401-7431</issn><eissn>1651-2006</eissn><abstract>Objectives Previous studies have suggested that urine albumin excretion (UAE) mirrors generalized vascular damage; however, it is unclear to which degree UAE mirrors small artery impairment. Design We enrolled 67 patients with uncomplicated essential hypertension (EH) during stable antihypertensive therapy. F-R
min
, ACR on three non-consecutive morning urine samples, pulse wave velocity (PWV), and 24-h ambulatory blood pressure (ABPM) were measured. Results ACR was low (0.39 and 0.30-0.60), but abnormal small artery structure defined as F-R
min
>
mean + 2 standard deviations of normotensive value (1.99 + 1 mmHg min/(ml/100 ml)) was present in 45% (n = 30). The mean F-R
min
was 2.89 ± 0.09 mmHg min/(ml/100 ml). ACR correlated significantly to PWV (r
2
=
0.11; p < 0.05) and pulse pressure (r
2
=
0.15; p < 0.001), but not F-R
min
and (r
2
=
0.05, p = 0.07). Conclusions Abnormal microvascular structure was present even in EH patients with low UAE. ACR correlated to arterial stiffness and not to small artery structure; therefore, UEA did not reflect microvascular damage in this population. ACR and F-R
min
thus reflect two distinct types of subclinical organ damage in hypertension.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>26856990</pmid><doi>10.3109/14017431.2016.1152397</doi><tpages>5</tpages></addata></record> |
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| ispartof | Scandinavian cardiovascular journal : SCJ, 2016-05, Vol.50 (3), p.167-171 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Albuminuria - etiology Albuminuria - physiopathology Antihypertensive Agents - administration & dosage Antihypertensive Agents - adverse effects Arteries - diagnostic imaging Arteries - physiopathology Creatinine - analysis Essential Hypertension Female forearm minimum vascular resistance Humans Hypertension - complications Hypertension - diagnosis Hypertension - drug therapy Hypertension - physiopathology Male Middle Aged Pulse Wave Analysis - methods pulse wave velocity Renal Elimination Reproducibility of Results Statistics as Topic urine albumin excretion Vascular Stiffness |
| title | Residual small artery impairment in hypertensive patients with normal albumin-creatinine ratio |
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