Comparison of the efficacy and endometrial safety of two estradiol valerate/dienogest combinations and Kliogest® for continuous combined hormone replacement therapy in postmenopausal women

Objective To compare the efficacy and endometrial safety of two estradiol valerate/dienogest combinations with Kliogest® in the treatment of postmenopausal symptoms. Design This was a double-blind, randomized, multicenter study. Methods Patients were randomized to estradiol valerate 2.0 mg/dienogest...

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Veröffentlicht in:	Climacteric : the journal of the International Menopause Society 2000, Vol.3 (2), p.109-118
Hauptverfasser:	Gräser, T., Koytchev, R., Müller, A., Oettel, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopsy Breast Diseases - chemically induced Climodien Continuous Combined HRT Dienogest Double-Blind Method Drug Combinations Endometrial Hyperplasia - chemically induced Endometrial Hyperplasia - pathology Endometrium Endometrium - drug effects Estradiol - administration & dosage Estradiol - adverse effects Estradiol - analogs & derivatives Estradiol Valerate Estriol - administration & dosage Estriol - adverse effects Estrogen Replacement Therapy - methods Female Hormone Replacement Therapy Humans Kliogest Nandrolone - administration & dosage Nandrolone - adverse effects Nandrolone - analogs & derivatives Norethindrone - administration & dosage Norethindrone - adverse effects Norethindrone - analogs & derivatives Postmenopause Prospective Studies Therapeutic Equivalency Treatment Outcome Uterine Hemorrhage - chemically induced
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