Prolonged Release of Drug from O/W Emulsion and Residence in Rat Nasal Cavity

ABSTRACT The present study evaluated the usefulness of an o/w emulsion for slowing the release of chlorphenira-mine maleate (CM) and prolonging drug residence in the nasal cavity. O/w emulsion formulations of medium chain triglycerides (MCT) were prepared, and their physicochemical properties and dr...

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Veröffentlicht in:	Pharmaceutical development and technology 1998, Vol.3 (4), p.461-469
Hauptverfasser:	Aikawa, Katsuyoshi, Matsumoto, Keiko, Uda, Harumi, Tanaka, Shigeo, Shimamura, Haruo, Aramaki, Yukihiko, Tsuchiya, Seishi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Biological and medical sciences Chlorpheniramine - administration & dosage Chlorpheniramine - pharmacokinetics Chlorpheniramine maleate Delayed-Action Preparations Deposit method Dialysis tube method Drug disappearance Emulsions General pharmacology Histamine and antagonists. Allergy Histamine H1 Antagonists - administration & dosage Hydrogen-Ion Concentration Medical sciences Medium chain triglycerides (MCT) Nasal Mucosa - metabolism O/w emulsion Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Rats, Wistar
Online-Zugang:	Volltext
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