Effect of different polymers and their combinations on the release of metoclopramide HCl from sustained-release hydrophilic matrix tablets

Metoclopramide HCl (MTC) is commonly used for the management of gastrointestinal disorders. It has a short biological half-life and is usually administered four times daily to maintain effective concentrations throughout the day. The aim of this study is to develop sustained-release hydrophilic matr...

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Veröffentlicht in:	Pharmaceutical development and technology 2013-09, Vol.18 (5), p.1122-1130
Hauptverfasser:	Sava er, Ayhan, Ta, Çetin, Bayrak, Ziya, Özkan, Cansel Köse, Özkan, Yalç n
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - chemistry Carboxymethylcellulose Sodium - chemistry Chemistry, Pharmaceutical - methods chitosan Chitosan - chemistry Delayed-Action Preparations Drug Compounding - methods Excipients - chemistry HPMC Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions matrix tablets Metoclopramide - chemistry Metoclopramide HCl Polymers - chemistry Solubility sustained release Tablets - chemistry
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