Long Term Effect of LDL Apheresis in Japan
LDL-apheresis is introduced in many cases all over Japan. Among them, evaluation of long-term effect on ischemic heart disease (IHD) has made on 10 cases with homozygous familial hypercholesterolemia (FH) and 49 cases with heterozygous FH. As to homozygous FH, 3 patients had angina pectoris. Mean du...
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| Veröffentlicht in: | Artificial cells, blood substitutes, and immobilization biotechnology blood substitutes, and immobilization biotechnology, 1991, Vol.19 (1), p.19-26 |
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| creator | Naito, Chikayuki Yamamoto, Akira Saito, Yasushi Muto, Eiji Nishide, Toshio Shinomiya, Masaki Mukai, Mikio Tomono, Shoichi Sato, Toshiya Yasuda, Kikuo Yamauchi, Toshiaki Mabuchi, Hiroshi Kobayashi, Junji Ueda, Hitoshi Nonaka, Kyohei Wada, Naruo Yamasak1, Satoru Ono, Toshihiko Yoshimura, Akira Harada, Mariko Nakamura, Haruo Kondo, Kazuo Ageta, Masato Matsui, Toshiharu Mayuyama, Hlroki Fukuo, Yoshihiro Matsuzawa, Yuji Irie, Yasufumi Kon, Tadamasa Endo, Michinori Yuasa, Yasuko Takahashi, Yukio Koda, Yutaka Hara, Yoji Kikkawa, Toshiro Oikawa, Shin-Ichi Ito, Hiro-O Homma, Yasuhiko Iino, Yasuhiko Takahashi, Yoshihiro Teramoto, Tamio Takahashi, Koki Mimori, Akio Takada, Hiroshi Suzuki, Mitsuru Kawanishi, Hideki Yashiro, Akira Tazaki, Hiromi Segawa, Jun Sugano, Kimihiro Kawashima, Takashi Matsushima, Toshio Nakajima, Yasuhide |
| description | LDL-apheresis is introduced in many cases all over Japan. Among them, evaluation of long-term effect on ischemic heart disease (IHD) has made on 10 cases with homozygous familial hypercholesterolemia (FH) and 49 cases with heterozygous FH.
As to homozygous FH, 3 patients had angina pectoris. Mean duration of treatment was 26 months (52 treatments). The changes in total cholesterol (TC) in each treatment was from 426 mg/dl to 151 mg/dl. Improvement in IHD was observed in 5 out of 10 cases.
As to heterozygous FH, 17 cases had history of myocardial infarction and 12 had angina pectoris. Mean duration of treatment was 13 months (19 treatments). Mean TC was decreased from 271 mg/dl to 126 mg/dl by each treatment. Regression in Achilles tendon thickenting or skin and palpebral xanthomas was observed. Frequency of anginal attacks decreased in 8 out of 17 cases. Ischemic change in ECG were improved in 3 out of 26 cases. Coronary angiography performed with 2 to 3 years of interval in some cases revealed regression or no progression in coronary stenosis. As a whole, IHD improved in 15 cases and exacerbated in 2 cases.
Main side effect was hypotension attack. Bradycardia and anginal attack during treatment were observed in some cases.
LDL-apheresis was judged as effective in 25 out of 44 patients with IHD or xanthoma. |
| doi_str_mv | 10.3109/10731199109117812 |
| format | Article |
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As to homozygous FH, 3 patients had angina pectoris. Mean duration of treatment was 26 months (52 treatments). The changes in total cholesterol (TC) in each treatment was from 426 mg/dl to 151 mg/dl. Improvement in IHD was observed in 5 out of 10 cases.
As to heterozygous FH, 17 cases had history of myocardial infarction and 12 had angina pectoris. Mean duration of treatment was 13 months (19 treatments). Mean TC was decreased from 271 mg/dl to 126 mg/dl by each treatment. Regression in Achilles tendon thickenting or skin and palpebral xanthomas was observed. Frequency of anginal attacks decreased in 8 out of 17 cases. Ischemic change in ECG were improved in 3 out of 26 cases. Coronary angiography performed with 2 to 3 years of interval in some cases revealed regression or no progression in coronary stenosis. As a whole, IHD improved in 15 cases and exacerbated in 2 cases.
Main side effect was hypotension attack. Bradycardia and anginal attack during treatment were observed in some cases.
LDL-apheresis was judged as effective in 25 out of 44 patients with IHD or xanthoma.</description><identifier>ISSN: 1073-1199</identifier><identifier>ISSN: 1055-7172</identifier><identifier>EISSN: 1532-4184</identifier><identifier>DOI: 10.3109/10731199109117812</identifier><language>eng</language><publisher>Informa UK Ltd</publisher><ispartof>Artificial cells, blood substitutes, and immobilization biotechnology, 1991, Vol.19 (1), p.19-26</ispartof><rights>1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1991</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c280t-5d3cb6753c024a0989ca4cd57a5c7615c0980a1f4ed62a8cf28aef3eb85dfb2e3</citedby><cites>FETCH-LOGICAL-c280t-5d3cb6753c024a0989ca4cd57a5c7615c0980a1f4ed62a8cf28aef3eb85dfb2e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/10731199109117812$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/10731199109117812$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,60409,61194,61375</link.rule.ids></links><search><creatorcontrib>Naito, Chikayuki</creatorcontrib><creatorcontrib>Yamamoto, Akira</creatorcontrib><creatorcontrib>Saito, Yasushi</creatorcontrib><creatorcontrib>Muto, Eiji</creatorcontrib><creatorcontrib>Nishide, Toshio</creatorcontrib><creatorcontrib>Shinomiya, Masaki</creatorcontrib><creatorcontrib>Mukai, Mikio</creatorcontrib><creatorcontrib>Tomono, Shoichi</creatorcontrib><creatorcontrib>Sato, Toshiya</creatorcontrib><creatorcontrib>Yasuda, Kikuo</creatorcontrib><creatorcontrib>Yamauchi, Toshiaki</creatorcontrib><creatorcontrib>Mabuchi, Hiroshi</creatorcontrib><creatorcontrib>Kobayashi, Junji</creatorcontrib><creatorcontrib>Ueda, Hitoshi</creatorcontrib><creatorcontrib>Nonaka, Kyohei</creatorcontrib><creatorcontrib>Wada, Naruo</creatorcontrib><creatorcontrib>Yamasak1, Satoru</creatorcontrib><creatorcontrib>Ono, Toshihiko</creatorcontrib><creatorcontrib>Yoshimura, Akira</creatorcontrib><creatorcontrib>Harada, Mariko</creatorcontrib><creatorcontrib>Nakamura, Haruo</creatorcontrib><creatorcontrib>Kondo, Kazuo</creatorcontrib><creatorcontrib>Ageta, Masato</creatorcontrib><creatorcontrib>Matsui, Toshiharu</creatorcontrib><creatorcontrib>Mayuyama, Hlroki</creatorcontrib><creatorcontrib>Fukuo, Yoshihiro</creatorcontrib><creatorcontrib>Matsuzawa, Yuji</creatorcontrib><creatorcontrib>Irie, Yasufumi</creatorcontrib><creatorcontrib>Kon, Tadamasa</creatorcontrib><creatorcontrib>Endo, Michinori</creatorcontrib><creatorcontrib>Yuasa, Yasuko</creatorcontrib><creatorcontrib>Takahashi, Yukio</creatorcontrib><creatorcontrib>Koda, Yutaka</creatorcontrib><creatorcontrib>Hara, Yoji</creatorcontrib><creatorcontrib>Kikkawa, Toshiro</creatorcontrib><creatorcontrib>Oikawa, Shin-Ichi</creatorcontrib><creatorcontrib>Ito, Hiro-O</creatorcontrib><creatorcontrib>Homma, Yasuhiko</creatorcontrib><creatorcontrib>Iino, Yasuhiko</creatorcontrib><creatorcontrib>Takahashi, Yoshihiro</creatorcontrib><creatorcontrib>Teramoto, Tamio</creatorcontrib><creatorcontrib>Takahashi, Koki</creatorcontrib><creatorcontrib>Mimori, Akio</creatorcontrib><creatorcontrib>Takada, Hiroshi</creatorcontrib><creatorcontrib>Suzuki, Mitsuru</creatorcontrib><creatorcontrib>Kawanishi, Hideki</creatorcontrib><creatorcontrib>Yashiro, Akira</creatorcontrib><creatorcontrib>Tazaki, Hiromi</creatorcontrib><creatorcontrib>Segawa, Jun</creatorcontrib><creatorcontrib>Sugano, Kimihiro</creatorcontrib><creatorcontrib>Kawashima, Takashi</creatorcontrib><creatorcontrib>Matsushima, Toshio</creatorcontrib><creatorcontrib>Nakajima, Yasuhide</creatorcontrib><title>Long Term Effect of LDL Apheresis in Japan</title><title>Artificial cells, blood substitutes, and immobilization biotechnology</title><description>LDL-apheresis is introduced in many cases all over Japan. Among them, evaluation of long-term effect on ischemic heart disease (IHD) has made on 10 cases with homozygous familial hypercholesterolemia (FH) and 49 cases with heterozygous FH.
As to homozygous FH, 3 patients had angina pectoris. Mean duration of treatment was 26 months (52 treatments). The changes in total cholesterol (TC) in each treatment was from 426 mg/dl to 151 mg/dl. Improvement in IHD was observed in 5 out of 10 cases.
As to heterozygous FH, 17 cases had history of myocardial infarction and 12 had angina pectoris. Mean duration of treatment was 13 months (19 treatments). Mean TC was decreased from 271 mg/dl to 126 mg/dl by each treatment. Regression in Achilles tendon thickenting or skin and palpebral xanthomas was observed. Frequency of anginal attacks decreased in 8 out of 17 cases. Ischemic change in ECG were improved in 3 out of 26 cases. Coronary angiography performed with 2 to 3 years of interval in some cases revealed regression or no progression in coronary stenosis. As a whole, IHD improved in 15 cases and exacerbated in 2 cases.
Main side effect was hypotension attack. Bradycardia and anginal attack during treatment were observed in some cases.
LDL-apheresis was judged as effective in 25 out of 44 patients with IHD or xanthoma.</description><issn>1073-1199</issn><issn>1055-7172</issn><issn>1532-4184</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNp9j01LxDAQhoMouK7-AG85C9VM0rQpelnW9YuCl_Vcpmliu7RNSSqy_96W9SKip3mZmWeGh5BLYNcCWHYDLBUAWTZlgFQBPyILkIJHMaj4eMrTPJoXTslZCDvGmIiBL8hV7vp3ujW-oxtrjR6pszS_z-lqqI03oQm06ekLDtifkxOLbTAX33VJ3h422_VTlL8-Pq9XeaS5YmMkK6HLJJVCMx4jy1SmMdaVTFHqNAGppxZDsLGpEo5KW67QWGFKJStbciOWBA53tXcheGOLwTcd-n0BrJhli1-yE3N3YJreOt_hp_NtVYy4b523HnvdhBn9G7_9gdcG27HW6E2xcx--n3T_ef4F4ONqkA</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>Naito, Chikayuki</creator><creator>Yamamoto, Akira</creator><creator>Saito, Yasushi</creator><creator>Muto, Eiji</creator><creator>Nishide, Toshio</creator><creator>Shinomiya, Masaki</creator><creator>Mukai, Mikio</creator><creator>Tomono, Shoichi</creator><creator>Sato, 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Yasuhide</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long Term Effect of LDL Apheresis in Japan</atitle><jtitle>Artificial cells, blood substitutes, and immobilization biotechnology</jtitle><date>1991</date><risdate>1991</risdate><volume>19</volume><issue>1</issue><spage>19</spage><epage>26</epage><pages>19-26</pages><issn>1073-1199</issn><issn>1055-7172</issn><eissn>1532-4184</eissn><abstract>LDL-apheresis is introduced in many cases all over Japan. Among them, evaluation of long-term effect on ischemic heart disease (IHD) has made on 10 cases with homozygous familial hypercholesterolemia (FH) and 49 cases with heterozygous FH.
As to homozygous FH, 3 patients had angina pectoris. Mean duration of treatment was 26 months (52 treatments). The changes in total cholesterol (TC) in each treatment was from 426 mg/dl to 151 mg/dl. Improvement in IHD was observed in 5 out of 10 cases.
As to heterozygous FH, 17 cases had history of myocardial infarction and 12 had angina pectoris. Mean duration of treatment was 13 months (19 treatments). Mean TC was decreased from 271 mg/dl to 126 mg/dl by each treatment. Regression in Achilles tendon thickenting or skin and palpebral xanthomas was observed. Frequency of anginal attacks decreased in 8 out of 17 cases. Ischemic change in ECG were improved in 3 out of 26 cases. Coronary angiography performed with 2 to 3 years of interval in some cases revealed regression or no progression in coronary stenosis. As a whole, IHD improved in 15 cases and exacerbated in 2 cases.
Main side effect was hypotension attack. Bradycardia and anginal attack during treatment were observed in some cases.
LDL-apheresis was judged as effective in 25 out of 44 patients with IHD or xanthoma.</abstract><pub>Informa UK Ltd</pub><doi>10.3109/10731199109117812</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1073-1199 |
| ispartof | Artificial cells, blood substitutes, and immobilization biotechnology, 1991, Vol.19 (1), p.19-26 |
| issn | 1073-1199 1055-7172 1532-4184 |
| language | eng |
| recordid | cdi_crossref_primary_10_3109_10731199109117812 |
| source | Taylor & Francis:Master (3349 titles) |
| title | Long Term Effect of LDL Apheresis in Japan |
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