Preparation and evaluation of dl-praeruptorin A microemulsion based hydrogel for dermal delivery

The purpose of the present investigation was to develop and optimize the microemulsion (ME) as a transdermal system for Pd-Ia, a poor water soluble and low bioavailable drug. The pseudo-ternary phase diagrams were constructed for various ME formulations including oleic acid as the oil phase, Cremoph...

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Veröffentlicht in:	Drug delivery 2015-08, Vol.22 (6), p.757-764
Hauptverfasser:	Zhang, Xianhua, Wu, Yueping, Hong, Ying, Zhu, Xuan, Lin, Liang, Lin, Qingjiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Animals Biological Availability Chemistry, Pharmaceutical Coumarins - administration & dosage Coumarins - pharmacokinetics Delayed-Action Preparations dl-praeruptorin A Drug Delivery Systems - methods Drug Stability Emulsions - chemistry Ethanol - chemistry Half-Life Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry hydrogels Hydrogen-Ion Concentration LC-MS/MS Male microemulsion Microscopy, Electron, Transmission Oleic Acid - chemistry Particle Size pharmacokinetics Polyethylene Glycols - chemistry Rats Rats, Sprague-Dawley Rheology Skin Absorption transdermal drug delivery Water - chemistry
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