Cyclodextrin modulates the cytotoxic effects of chlorhexidine on microrganisms and cells in vitro

Abstract Although several studies have shown that chlorhexidine (Cx) has bactericidal activity and exerts toxic effects on periodontal tissues a few studies evaluated mechanisms to reduce its adverse effects maintaining the antimicrobial properties. Therefore, the aim of the present study was to inv...

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Veröffentlicht in:	Drug delivery 2015-05, Vol.22 (3), p.444-453
Hauptverfasser:	Teixeira, K. I. R., Denadai, A. M. L., Sinisterra, R. D., Cortés, M. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregatibacter actinomycetemcomitans - drug effects Animals Anti-Infective Agents - administration & dosage Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antimicrobial Caco-2 Cells Candida albicans - drug effects Cell Survival - drug effects Cells, Cultured chlorhexidine Chlorhexidine - administration & dosage Chlorhexidine - chemistry Chlorhexidine - pharmacology cyclodextrin Cyclodextrins - chemistry Cyclodextrins - pharmacology cytotoxicity Drug Carriers - chemistry Drug Carriers - pharmacology Fibroblasts - drug effects Humans Mice Microbial Sensitivity Tests Osteoblasts - drug effects Rats, Wistar Streptococcus mutans - drug effects toxicological
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