Non-Enzymic Lipid Peroxidation in Microsomes and Microsomal Phospholipids Induced by Anthracyclines

The stimulation of non-enzymic lipid peroxidation by doxorubicin, daunorubicin and 7 derivatives was investigated in extracted microsomal phospholipids and in intact microsomes. Evidence was obtained for the necessity of a free amino-sugar moiety for a stimulative effect on lipid peroxidation. Bindi...

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Veröffentlicht in:	Free radical research 1986, Vol.1 (6), p.369-378
Hauptverfasser:	Sterrenberg, Lydi, Julicher, Rinette H.M., Goossens, Peter A.L., Bast, Aalt, Noordhoek, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anthracyclines Antibiotics, Antineoplastic - pharmacology Iron - metabolism iron ions lipid peroxidation Lipid Peroxidation - drug effects Male microsomal phospholipids microsomes Microsomes, Liver - drug effects Microsomes, Liver - metabolism Phospholipids - metabolism Rats Rats, Inbred Strains
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