The Anti-Hypertensive Effect of Potassium Loading in Experimental Hypertension: A Comparison of Sheep with Other Species
The anti-hypertensive effect of potassium (K) loading in human essential hypertension and several types of experimental hypertension is well established. However, the mechanism of the anti-hypertensive effect is not understood. The natriuretic effect of a high K intake has lead many to conclude that...
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| Veröffentlicht in: | Clinical and experimental hypertension (1993) 1988, Vol.A10 (2), p.289-309 |
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| container_start_page | 289 |
| container_title | Clinical and experimental hypertension (1993) |
| container_volume | A10 |
| creator | Mills, Eric. H. Coghlan, John P. Denton, Derek A. Spence, Campbell D. Whitworth, Judith A. Scoggins, Bruce A. |
| description | The anti-hypertensive effect of potassium (K) loading in human essential hypertension and several types of experimental hypertension is well established. However, the mechanism of the anti-hypertensive effect is not understood. The natriuretic effect of a high K intake has lead many to conclude that the blood pressure lowering effect of K may be mediated through enhanced sodium (Na) excretion leading to negative Na status. Review of the literature suggests that the anti-hypertensive effect of K loading, at least in sheep, can not be explained simply by changes in Na excretion. |
| doi_str_mv | 10.3109/10641968809103528 |
| format | Article |
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H. ; Coghlan, John P. ; Denton, Derek A. ; Spence, Campbell D. ; Whitworth, Judith A. ; Scoggins, Bruce A.</creator><creatorcontrib>Mills, Eric. H. ; Coghlan, John P. ; Denton, Derek A. ; Spence, Campbell D. ; Whitworth, Judith A. ; Scoggins, Bruce A.</creatorcontrib><description>The anti-hypertensive effect of potassium (K) loading in human essential hypertension and several types of experimental hypertension is well established. However, the mechanism of the anti-hypertensive effect is not understood. The natriuretic effect of a high K intake has lead many to conclude that the blood pressure lowering effect of K may be mediated through enhanced sodium (Na) excretion leading to negative Na status. Review of the literature suggests that the anti-hypertensive effect of K loading, at least in sheep, can not be explained simply by changes in Na excretion.</description><identifier>ISSN: 1064-1963</identifier><identifier>ISSN: 0730-0077</identifier><identifier>EISSN: 1525-6006</identifier><identifier>DOI: 10.3109/10641968809103528</identifier><identifier>PMID: 3370848</identifier><identifier>CODEN: CEHADM</identifier><language>eng</language><publisher>Basel: Informa UK Ltd</publisher><subject>Animals ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; blood pressure ; Blood Pressure - drug effects ; Cardiology. Vascular system ; Central Nervous System - drug effects ; Central Nervous System - physiopathology ; dog ; Dogs ; Experimental diseases ; Humans ; Hypertension - blood ; Hypertension - physiopathology ; man ; Medical sciences ; potassium ; Potassium - blood ; Potassium - pharmacology ; rat ; Rats ; Renin-Angiotensin System - drug effects ; Sheep ; sodium ; Sodium - blood ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - physiopathology ; Vascular Resistance - drug effects</subject><ispartof>Clinical and experimental hypertension (1993), 1988, Vol.A10 (2), p.289-309</ispartof><rights>1988 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-2ac9d7b1007d4d656931b406eab319772f9b4fa6bfe3ee08e9f85c33a3c6b5303</citedby><cites>FETCH-LOGICAL-c430t-2ac9d7b1007d4d656931b406eab319772f9b4fa6bfe3ee08e9f85c33a3c6b5303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/10641968809103528$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/10641968809103528$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,60409,61194,61375</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7133387$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3370848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mills, Eric. H.</creatorcontrib><creatorcontrib>Coghlan, John P.</creatorcontrib><creatorcontrib>Denton, Derek A.</creatorcontrib><creatorcontrib>Spence, Campbell D.</creatorcontrib><creatorcontrib>Whitworth, Judith A.</creatorcontrib><creatorcontrib>Scoggins, Bruce A.</creatorcontrib><title>The Anti-Hypertensive Effect of Potassium Loading in Experimental Hypertension: A Comparison of Sheep with Other Species</title><title>Clinical and experimental hypertension (1993)</title><addtitle>Clin Exp Hypertens A</addtitle><description>The anti-hypertensive effect of potassium (K) loading in human essential hypertension and several types of experimental hypertension is well established. However, the mechanism of the anti-hypertensive effect is not understood. The natriuretic effect of a high K intake has lead many to conclude that the blood pressure lowering effect of K may be mediated through enhanced sodium (Na) excretion leading to negative Na status. Review of the literature suggests that the anti-hypertensive effect of K loading, at least in sheep, can not be explained simply by changes in Na excretion.</description><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiology. Vascular system</subject><subject>Central Nervous System - drug effects</subject><subject>Central Nervous System - physiopathology</subject><subject>dog</subject><subject>Dogs</subject><subject>Experimental diseases</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Hypertension - physiopathology</subject><subject>man</subject><subject>Medical sciences</subject><subject>potassium</subject><subject>Potassium - blood</subject><subject>Potassium - pharmacology</subject><subject>rat</subject><subject>Rats</subject><subject>Renin-Angiotensin System - drug effects</subject><subject>Sheep</subject><subject>sodium</subject><subject>Sodium - blood</subject><subject>Sympathetic Nervous System - drug effects</subject><subject>Sympathetic Nervous System - physiopathology</subject><subject>Vascular Resistance - drug effects</subject><issn>1064-1963</issn><issn>0730-0077</issn><issn>1525-6006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhk1pSdO0D9BDQYfSm1PJY8tym8uybJvCQgJJz0aWR7WCLbmS3GTfvgq7SSmBnDTwf9-g-bPsPaOnwGjzmVFesoYLQRtGoSrEi-yYVUWVc0r5yzSnPE8AvM7ehHBDKSt5JY6yI4CailIcZ3fXA5KVjSY_383oI9pg_iDZaI0qEqfJpYsyBLNMZOtkb-wvYizZ3CXWTGijHMk_0dkvZEXWbpqlN8HZe_9qQJzJrYkDuYgDenI1ozIY3mavtBwDvju8J9nPb5vr9Xm-vfj-Y73a5qoEGvNCqqavO0Zp3Zc9r3gDrCspR9kBa-q60E1Xask7jYBIBTZaVApAguJdBRROsk_7vbN3vxcMsZ1MUDiO0qJbQluLooCq5Alke1B5F4JH3c7pROl3LaPtfdvtk7aT8-GwfOkm7B-NQ70p_3jIZVBy1F5aZcIjVjMAEHXCzvaYsdr5Sd46P_ZtlLvR-QcHnvvF1__0AeUYByU9tjdu8TbV-8wNfwGpZK0p</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Mills, Eric. H.</creator><creator>Coghlan, John P.</creator><creator>Denton, Derek A.</creator><creator>Spence, Campbell D.</creator><creator>Whitworth, Judith A.</creator><creator>Scoggins, Bruce A.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>The Anti-Hypertensive Effect of Potassium Loading in Experimental Hypertension: A Comparison of Sheep with Other Species</title><author>Mills, Eric. H. ; Coghlan, John P. ; Denton, Derek A. ; Spence, Campbell D. ; Whitworth, Judith A. ; Scoggins, Bruce A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-2ac9d7b1007d4d656931b406eab319772f9b4fa6bfe3ee08e9f85c33a3c6b5303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiology. Vascular system</topic><topic>Central Nervous System - drug effects</topic><topic>Central Nervous System - physiopathology</topic><topic>dog</topic><topic>Dogs</topic><topic>Experimental diseases</topic><topic>Humans</topic><topic>Hypertension - blood</topic><topic>Hypertension - physiopathology</topic><topic>man</topic><topic>Medical sciences</topic><topic>potassium</topic><topic>Potassium - blood</topic><topic>Potassium - pharmacology</topic><topic>rat</topic><topic>Rats</topic><topic>Renin-Angiotensin System - drug effects</topic><topic>Sheep</topic><topic>sodium</topic><topic>Sodium - blood</topic><topic>Sympathetic Nervous System - drug effects</topic><topic>Sympathetic Nervous System - physiopathology</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mills, Eric. H.</creatorcontrib><creatorcontrib>Coghlan, John P.</creatorcontrib><creatorcontrib>Denton, Derek A.</creatorcontrib><creatorcontrib>Spence, Campbell D.</creatorcontrib><creatorcontrib>Whitworth, Judith A.</creatorcontrib><creatorcontrib>Scoggins, Bruce A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental hypertension (1993)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mills, Eric. H.</au><au>Coghlan, John P.</au><au>Denton, Derek A.</au><au>Spence, Campbell D.</au><au>Whitworth, Judith A.</au><au>Scoggins, Bruce A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Anti-Hypertensive Effect of Potassium Loading in Experimental Hypertension: A Comparison of Sheep with Other Species</atitle><jtitle>Clinical and experimental hypertension (1993)</jtitle><addtitle>Clin Exp Hypertens A</addtitle><date>1988</date><risdate>1988</risdate><volume>A10</volume><issue>2</issue><spage>289</spage><epage>309</epage><pages>289-309</pages><issn>1064-1963</issn><issn>0730-0077</issn><eissn>1525-6006</eissn><coden>CEHADM</coden><abstract>The anti-hypertensive effect of potassium (K) loading in human essential hypertension and several types of experimental hypertension is well established. However, the mechanism of the anti-hypertensive effect is not understood. The natriuretic effect of a high K intake has lead many to conclude that the blood pressure lowering effect of K may be mediated through enhanced sodium (Na) excretion leading to negative Na status. Review of the literature suggests that the anti-hypertensive effect of K loading, at least in sheep, can not be explained simply by changes in Na excretion.</abstract><cop>Basel</cop><cop>Hong Kong</cop><cop>New York, NY</cop><pub>Informa UK Ltd</pub><pmid>3370848</pmid><doi>10.3109/10641968809103528</doi><tpages>21</tpages></addata></record> |
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| ispartof | Clinical and experimental hypertension (1993), 1988, Vol.A10 (2), p.289-309 |
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| source | Taylor & Francis Online; MEDLINE |
| subjects | Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels blood pressure Blood Pressure - drug effects Cardiology. Vascular system Central Nervous System - drug effects Central Nervous System - physiopathology dog Dogs Experimental diseases Humans Hypertension - blood Hypertension - physiopathology man Medical sciences potassium Potassium - blood Potassium - pharmacology rat Rats Renin-Angiotensin System - drug effects Sheep sodium Sodium - blood Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiopathology Vascular Resistance - drug effects |
| title | The Anti-Hypertensive Effect of Potassium Loading in Experimental Hypertension: A Comparison of Sheep with Other Species |
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