Spironolactone: A Glucocorticoid Agonist or Antagonist?

Spironolactone displaces 3H-dexamethasone from HTC cell nuclei and inhibits the induction of tyrosine aminotransferase (TAT) activity by dexamethasone in HTC cells. Spironolactone alone fails to increase TAT activity in HTC cells or in the liver of adrenalectomized rats. These actions indicate that...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical and experimental hypertension (1993) 1982, Vol.A4 (9-10), p.1627-1636
Hauptverfasser:	Campen, Thomas J., Fanestil, Darrell D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenalectomy Animals Cell Line Cell Nucleus - metabolism Dexamethasone - metabolism Dexamethasone - pharmacology Enzyme Induction - drug effects Liver Neoplasms, Experimental - metabolism Male Rats Receptors, Glucocorticoid - drug effects Receptors, Glucocorticoid - metabolism Receptors, Steroid - metabolism Spironolactone - pharmacology Tyrosine Transaminase - biosynthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Spironolactone displaces 3H-dexamethasone from HTC cell nuclei and inhibits the induction of tyrosine aminotransferase (TAT) activity by dexamethasone in HTC cells. Spironolactone alone fails to increase TAT activity in HTC cells or in the liver of adrenalectomized rats. These actions indicate that spironolactone lacks glucocorticoid agonist activity but can be an antagonistic to the actions of glucocorticoid as well as mineralocorticoid steroid hormones.
ISSN:	1064-1963 0730-0077 1525-6006
DOI:	10.3109/10641968209061629