The Putative Mechanistic Basis for the Modulatory Role of Endothelin-1 in the Altered Vascular Tone Induced by Trypanosoma cruzi

Chagas' disease, caused by Trypanosoma cruzi, is an important cause of heart disease in Latin America. T. cruzi-induced microvascular compromise, in turn, is thought to play a major role in chagasic heart disease. Previous in vitro studies have implicated endothelin-1 (ET-1) as a potentially im...

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Veröffentlicht in:	Endothelium (New York, N.Y.) N.Y.), 1999, Vol.6 (3), p.217-230
Hauptverfasser:	Tanowitz, Herbert B., Wittner, Murray, Morris, Stephen A., Zhao, Weixin, Weiss, Louis M., Hatcher, Victor B., Braunstein, Vicki L., Huang, Huan, Douglas, Stephen A., Valcic, Mira, Spektor, Mariya, Christ, George J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - drug effects Aorta - physiology Calcium - metabolism Cells, Cultured Chagas Cardiomyopathy - metabolism Chagas Cardiomyopathy - physiopathology Chagas' disease endothelial cells endothelin Endothelin Receptor Antagonists Endothelin-1 - biosynthesis Endothelin-1 - physiology Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Endothelium, Vascular - parasitology Endothelium, Vascular - physiopathology Glycopeptides - pharmacology Humans Intracellular Fluid - metabolism Mice Muscle Contraction - drug effects Muscle Contraction - physiology Muscle, Smooth, Vascular - cytology Peptides, Cyclic - pharmacology phosphoramidon Protease Inhibitors - pharmacology Rats Receptor, Endothelin A Trypanosoma cruzi Trypanosoma cruzi - physiology vascular smooth muscle cells Vasoconstriction - drug effects Vasodilator Agents - pharmacology verapamil Verapamil - pharmacology
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