Growth Inhibition of Macrophage-Like and Other Cell Types by Liposome-Encapsulated, Calcium-Bound, and Free Bisphosphonates In Vitro

Abstract Bisphosphonates effectively inhibit osteoclastic bone resorption in diseases characterized by excessive bone loss. Liposome-encapsulated clodronate (dichloromethylene bisphosphonate) also is known to inactivate phagocytic cells in vivo, and inhibit the growth of macrophage-like RAW 264 cell...

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Veröffentlicht in:	Journal of drug targeting 1994, Vol.2 (4), p.299-308
Hauptverfasser:	Mönkkönen, Jukka, Taskinen, Markku, Auriola, Seppo O.K., Urtti, Arto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoimmune disease Bisphosphonates Calcium Calcium - metabolism Cell Division - drug effects Cell Line Cercopithecus aethiops Clodronic Acid - administration & dosage Clodronic Acid - metabolism Clodronic Acid - pharmacology Delayed-Action Preparations Diphosphonates - administration & dosage Diphosphonates - metabolism Diphosphonates - pharmacology Drug Carriers Etidronic Acid - administration & dosage Etidronic Acid - metabolism Etidronic Acid - pharmacology Humans Kidney - cytology Leukemia Liposomes Macrophages Macrophages - cytology Macrophages - drug effects Mice Phagocytes - drug effects Tumor Cells, Cultured
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