Serum Levels of TNF, IL-6 and sCD23 Correlate with Changes in Lymphocyte Count in Patients with B-Cell Chronic Lymphocytic Leukaemia Receiving Interferon-Alpha Therapy

The control of cell growth and differentiation in B-cell malignancies may be regulated by the autocrine production of cytokines, several of which have been implicated in the growth and survival of B-cells. The effect of interferon-alpha (IFN) therapy in these disorders may be to disrupt autocrine gr...

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Veröffentlicht in:	Leukemia & lymphoma 1997, Vol.24 (3-4), p.327-333
Hauptverfasser:	Jewell, A. P., Worman, C. P., Giles, F. J., Goldstone, A. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	B-CLL Humans Immunologic Factors - therapeutic use Interferon alpha-2 interferon-alpha Interferon-alpha - therapeutic use Interleukin-1 - blood interleukin-6 Interleukin-6 - blood Leukemia, Lymphocytic, Chronic, B-Cell - blood Leukemia, Lymphocytic, Chronic, B-Cell - therapy Lymphocyte Count lyniphocytic leukemia Neoplasm Proteins - blood Receptors, IgE - blood Recombinant Proteins sCD23 TNF Tumor Necrosis Factor-alpha - analysis
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