Leukemic Transformation of Primary Myelofibrosis: Immunophenotype, Genotype and Growth Characteristics of Blast Cells

Blast cells from six patients with leukemic transformation of primary myelofibrosis (PMF) were studied by morphology, immunophenotype and genotype as well as response to hematopoietic growth factors. The majority of the patients showed granulocytic or granulo-monocytic blasts, and only one had T lym...

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Veröffentlicht in:	Leukemia & lymphoma 1995, Vol.19 (5-6), p.493-498
Hauptverfasser:	Kimura, Akiro, Kawaishi, Kuniko, Nakata, Yoshio, Hyodo, Hideo, Kuramoto, Atsushi, Satow, Yukio
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Antigens, CD - analysis Antigens, Neoplasm - analysis Base Sequence Biomarkers, Tumor - analysis Cell Division - drug effects Cell Transformation, Neoplastic - genetics Disease Progression DNA, Neoplasm - genetics Drug Synergism Female G-CSF Genotype GM-CSF Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Humans IL-3 Immunophenotyping Interleukin-3 - pharmacology Leukemia, Myeloid - genetics Leukemia, Myeloid - pathology Male Middle Aged Molecular Sequence Data myeloid leukemia Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology primary myelofibrosis Primary Myelofibrosis - genetics Primary Myelofibrosis - pathology stem cell factor Stem Cell Factor - pharmacology Tumor Cells, Cultured - drug effects
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