Over-Expression of the Functional Interleukin-11α Receptor in the Development of B-Cell Chronic Lymphocytic Leukemia

Several cytokines have been found to play a role in the pathogenesis of B-CLL. In the present study using reverse-transcriptase polymerase chain reaction (RT-PCR), FACS analysis and immunofluorescence we have shown the constitutive expression of IL-11 and IL-11Rα in B-chronic lymphocytic leukemia (B...

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Veröffentlicht in:	Leukemia & lymphoma 2001, Vol.42 (1-2), p.195-205
Hauptverfasser:	Tsimanis, Alexander, Shvidel, Lev, Klepfish, Abraham, Shtalrid, Mordehai, Kalinkovich, Alexander, Berrebi, Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Apoptosis - drug effects B-chronic lymphocytic leukemia B-Lymphocytes - drug effects B-Lymphocytes - metabolism B-Lymphocytes - pathology Case-Control Studies Cell Culture Techniques expression Humans interleukin-11 Interleukin-11 - genetics Interleukin-11 - pharmacology Interleukin-11 Receptor alpha Subunit interleukin-11α receptor Leukemia, Lymphocytic, Chronic, B-Cell - blood Leukemia, Lymphocytic, Chronic, B-Cell - etiology Lymphocyte Activation - drug effects Middle Aged Receptors, Interleukin - genetics Receptors, Interleukin-11 Recombinant Proteins - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis RNA, Messenger - metabolism
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