Effects of Methadone Use During Pregnancy on Human Placental Opioid Receptors
Human placenta was used to investigate the effects of chronic methadone use during pregnancy on villus tissue opioid receptors. Patients included in this investigation received 35-60 mg methadone per day. Methadone-exposed placenta villus tissue had no detectable opioid receptor binding sites measur...
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Veröffentlicht in: | Membrane biochemistry 1993, Vol.10 (2), p.91-98 |
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description | Human placenta was used to investigate the effects of chronic methadone use during pregnancy on villus tissue opioid receptors. Patients included in this investigation received 35-60 mg methadone per day. Methadone-exposed placenta villus tissue had no detectable opioid receptor binding sites measured by tritiated opioid agonists. In vitro release of acetylcholine and hCG from trophoblast tissue of methadone-exposed placentas was not modulated by opioids. Absence of opioid receptor binding sites and their two mediated responses in trophoblast tissue of placentas obtained from patients with documented chronic methadone use during pregnancy indicate that the receptors were down regulated or desensitized. |
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Patients included in this investigation received 35-60 mg methadone per day. Methadone-exposed placenta villus tissue had no detectable opioid receptor binding sites measured by tritiated opioid agonists. In vitro release of acetylcholine and hCG from trophoblast tissue of methadone-exposed placentas was not modulated by opioids. Absence of opioid receptor binding sites and their two mediated responses in trophoblast tissue of placentas obtained from patients with documented chronic methadone use during pregnancy indicate that the receptors were down regulated or desensitized.</description><identifier>ISSN: 0968-7688</identifier><identifier>ISSN: 0149-046X</identifier><identifier>EISSN: 1464-5203</identifier><identifier>DOI: 10.3109/09687689309150256</identifier><identifier>PMID: 8395641</identifier><identifier>CODEN: MEBIDO</identifier><language>eng</language><publisher>Washington, DC: Informa UK Ltd</publisher><subject>Acetylcholine - secretion ; Adult ; Biological and medical sciences ; Chorionic Gonadotropin - secretion ; Down-Regulation - drug effects ; Drug addictions ; Drug Administration Schedule ; drug use ; Female ; Humans ; Medical sciences ; Methadone - pharmacology ; Opioid receptors ; Placenta - drug effects ; Placenta - physiology ; Placenta - ultrastructure ; Pregnancy ; Pregnancy Complications - chemically induced ; Receptors, Opioid - drug effects ; Receptors, Opioid - metabolism ; Receptors, Opioid - physiology ; Toxicology ; Trophoblasts - drug effects ; Trophoblasts - secretion ; Trophoblasts - ultrastructure</subject><ispartof>Membrane biochemistry, 1993, Vol.10 (2), p.91-98</ispartof><rights>1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1993</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-94ad5491910184241ec36b75870b9ba7d134ed058839e9794c8c6b727112b0413</citedby><cites>FETCH-LOGICAL-c430t-94ad5491910184241ec36b75870b9ba7d134ed058839e9794c8c6b727112b0413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/09687689309150256$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/09687689309150256$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,60409,61194,61375</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4109585$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8395641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmed, Mahmoud S.</creatorcontrib><creatorcontrib>Cemerikic, Bojana</creatorcontrib><creatorcontrib>Mou, Susan</creatorcontrib><creatorcontrib>Agbas, Abdulbaki</creatorcontrib><title>Effects of Methadone Use During Pregnancy on Human Placental Opioid Receptors</title><title>Membrane biochemistry</title><addtitle>Membr Biochem</addtitle><description>Human placenta was used to investigate the effects of chronic methadone use during pregnancy on villus tissue opioid receptors. Patients included in this investigation received 35-60 mg methadone per day. Methadone-exposed placenta villus tissue had no detectable opioid receptor binding sites measured by tritiated opioid agonists. In vitro release of acetylcholine and hCG from trophoblast tissue of methadone-exposed placentas was not modulated by opioids. Absence of opioid receptor binding sites and their two mediated responses in trophoblast tissue of placentas obtained from patients with documented chronic methadone use during pregnancy indicate that the receptors were down regulated or desensitized.</description><subject>Acetylcholine - secretion</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Chorionic Gonadotropin - secretion</subject><subject>Down-Regulation - drug effects</subject><subject>Drug addictions</subject><subject>Drug Administration Schedule</subject><subject>drug use</subject><subject>Female</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Methadone - pharmacology</subject><subject>Opioid receptors</subject><subject>Placenta - drug effects</subject><subject>Placenta - physiology</subject><subject>Placenta - ultrastructure</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - chemically induced</subject><subject>Receptors, Opioid - drug effects</subject><subject>Receptors, Opioid - metabolism</subject><subject>Receptors, Opioid - physiology</subject><subject>Toxicology</subject><subject>Trophoblasts - drug effects</subject><subject>Trophoblasts - secretion</subject><subject>Trophoblasts - ultrastructure</subject><issn>0968-7688</issn><issn>0149-046X</issn><issn>1464-5203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1KxDAYRYMoOv48gAshC3FXTZqkTdCNjL-gKKLrkqZfnUqajEmLzNsbmVEQwVUW99zLl4PQPiXHjBJ1QlQhy0IqRhQVJBfFGppQXvBM5ISto8lXniVAbqHtGN8IIbwo-CbalEyJgtMJur9sWzBDxL7F9zDMdOMd4JcI-GIMnXvFjwFenXZmgb3DN2OvHX602oAbtMUP8853DX4CA_PBh7iLNlptI-yt3h30cnX5PL3J7h6ub6fnd5nhjAyZ4roRXFFFCZU85xQMK-pSyJLUqtZlQxmHhgiZzgRVKm6kSXleUprXhFO2g46Wu_Pg30eIQ9V30YC12oEfY1UKlTMqeALpEjTBxxigreah63VYVJRUXwqrPwpT52A1PtY9ND-NlbOUH65yHY22bUh2uviD8bQqpEjY2RLrXOtDrz98sE016IX14bvD_rvi9Fd9BtoOM6MDVG9-DC7p_ecPn6_6m7Q</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Ahmed, Mahmoud S.</creator><creator>Cemerikic, Bojana</creator><creator>Mou, Susan</creator><creator>Agbas, Abdulbaki</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1993</creationdate><title>Effects of Methadone Use During Pregnancy on Human Placental Opioid Receptors</title><author>Ahmed, Mahmoud S. ; Cemerikic, Bojana ; Mou, Susan ; Agbas, Abdulbaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-94ad5491910184241ec36b75870b9ba7d134ed058839e9794c8c6b727112b0413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Acetylcholine - secretion</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Chorionic Gonadotropin - secretion</topic><topic>Down-Regulation - drug effects</topic><topic>Drug addictions</topic><topic>Drug Administration Schedule</topic><topic>drug use</topic><topic>Female</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Methadone - pharmacology</topic><topic>Opioid receptors</topic><topic>Placenta - drug effects</topic><topic>Placenta - physiology</topic><topic>Placenta - ultrastructure</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - chemically induced</topic><topic>Receptors, Opioid - drug effects</topic><topic>Receptors, Opioid - metabolism</topic><topic>Receptors, Opioid - physiology</topic><topic>Toxicology</topic><topic>Trophoblasts - drug effects</topic><topic>Trophoblasts - secretion</topic><topic>Trophoblasts - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed, Mahmoud S.</creatorcontrib><creatorcontrib>Cemerikic, Bojana</creatorcontrib><creatorcontrib>Mou, Susan</creatorcontrib><creatorcontrib>Agbas, Abdulbaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Membrane biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed, Mahmoud S.</au><au>Cemerikic, Bojana</au><au>Mou, Susan</au><au>Agbas, Abdulbaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Methadone Use During Pregnancy on Human Placental Opioid Receptors</atitle><jtitle>Membrane biochemistry</jtitle><addtitle>Membr Biochem</addtitle><date>1993</date><risdate>1993</risdate><volume>10</volume><issue>2</issue><spage>91</spage><epage>98</epage><pages>91-98</pages><issn>0968-7688</issn><issn>0149-046X</issn><eissn>1464-5203</eissn><coden>MEBIDO</coden><abstract>Human placenta was used to investigate the effects of chronic methadone use during pregnancy on villus tissue opioid receptors. Patients included in this investigation received 35-60 mg methadone per day. Methadone-exposed placenta villus tissue had no detectable opioid receptor binding sites measured by tritiated opioid agonists. In vitro release of acetylcholine and hCG from trophoblast tissue of methadone-exposed placentas was not modulated by opioids. Absence of opioid receptor binding sites and their two mediated responses in trophoblast tissue of placentas obtained from patients with documented chronic methadone use during pregnancy indicate that the receptors were down regulated or desensitized.</abstract><cop>Washington, DC</cop><cop>Philadelphia, PA</cop><cop>New York, NY</cop><pub>Informa UK Ltd</pub><pmid>8395641</pmid><doi>10.3109/09687689309150256</doi><tpages>8</tpages></addata></record> |
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subjects | Acetylcholine - secretion Adult Biological and medical sciences Chorionic Gonadotropin - secretion Down-Regulation - drug effects Drug addictions Drug Administration Schedule drug use Female Humans Medical sciences Methadone - pharmacology Opioid receptors Placenta - drug effects Placenta - physiology Placenta - ultrastructure Pregnancy Pregnancy Complications - chemically induced Receptors, Opioid - drug effects Receptors, Opioid - metabolism Receptors, Opioid - physiology Toxicology Trophoblasts - drug effects Trophoblasts - secretion Trophoblasts - ultrastructure |
title | Effects of Methadone Use During Pregnancy on Human Placental Opioid Receptors |
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