Effects of Methadone Use During Pregnancy on Human Placental Opioid Receptors

Human placenta was used to investigate the effects of chronic methadone use during pregnancy on villus tissue opioid receptors. Patients included in this investigation received 35-60 mg methadone per day. Methadone-exposed placenta villus tissue had no detectable opioid receptor binding sites measur...

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Veröffentlicht in:Membrane biochemistry 1993, Vol.10 (2), p.91-98
Hauptverfasser: Ahmed, Mahmoud S., Cemerikic, Bojana, Mou, Susan, Agbas, Abdulbaki
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container_title Membrane biochemistry
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creator Ahmed, Mahmoud S.
Cemerikic, Bojana
Mou, Susan
Agbas, Abdulbaki
description Human placenta was used to investigate the effects of chronic methadone use during pregnancy on villus tissue opioid receptors. Patients included in this investigation received 35-60 mg methadone per day. Methadone-exposed placenta villus tissue had no detectable opioid receptor binding sites measured by tritiated opioid agonists. In vitro release of acetylcholine and hCG from trophoblast tissue of methadone-exposed placentas was not modulated by opioids. Absence of opioid receptor binding sites and their two mediated responses in trophoblast tissue of placentas obtained from patients with documented chronic methadone use during pregnancy indicate that the receptors were down regulated or desensitized.
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source Taylor & Francis; MEDLINE
subjects Acetylcholine - secretion
Adult
Biological and medical sciences
Chorionic Gonadotropin - secretion
Down-Regulation - drug effects
Drug addictions
Drug Administration Schedule
drug use
Female
Humans
Medical sciences
Methadone - pharmacology
Opioid receptors
Placenta - drug effects
Placenta - physiology
Placenta - ultrastructure
Pregnancy
Pregnancy Complications - chemically induced
Receptors, Opioid - drug effects
Receptors, Opioid - metabolism
Receptors, Opioid - physiology
Toxicology
Trophoblasts - drug effects
Trophoblasts - secretion
Trophoblasts - ultrastructure
title Effects of Methadone Use During Pregnancy on Human Placental Opioid Receptors
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